FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term execution phase of apoptosis ID (Ontology) GO:0097194 (Gene Ontology)
Definition A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.[ PubMed:21760595 ]
Also Known As"execution phase of apoptotic process"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 execution phase of apoptosis (all annotations which use CV term, excluding "NOT" statements)
     involved_in | execution phase of apoptosis       --
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biological_process
 |__cellular process___
programmed cell death  |
 |__apoptotic process__|
                       execution phase of apoptosis  31 rec.
                        |__cellular component disassembly involved in execution phase of apoptosis 18 rec.
                        |   |__apoptotic nuclear changes(+) 18 rec.
                        |__phosphatidylserine exposure on apoptotic cell surface 2 rec.
                        |   |__regulation of phosphatidylserine exposure on apoptotic cell surface(+)
                        |__regulation of execution phase of apoptosis 4 rec.
                            |__negative regulation of execution phase of apoptosis(+) 1 rec.
                            |__positive regulation of execution phase of apoptosis
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Is a cellular process
Part of apoptotic process
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Synonyms
  • "apoptosis" NARROW
    "execution phase of apoptotic process" EXACT
Secondary IDs
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Reactome:R-HSA-75153 "Apoptotic execution phase"