Dcp-2/Dredd, Dcp-2, EG:115C2.9 , Dcp2
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
494, 488 (aa)
When apoptosis is triggered by the expression of rpr, grim, or W proteins, caspase-like processing of the the α, γ, and δ isoforms of Dredd protein occurs. (It is likely that the putative α isoform is a truncated form of the δ isoform.)
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit (PubMed:9740659). Interacts (via N-terminus) with Diap2; likely to bind Diap2 simultaneously with Fadd to form a trimeric complex (PubMed:10934188, PubMed:22549468).
Polyubiquitinated by Diap2 following activation of the immune deficiency (Imd) pathway.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dredd using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Dredd in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Dredd anon-1BCa
Changed ‘protein’ to ‘caspase’ in the gene fullname to be more informative and consistent with fullnames of other caspase-encoding genes.
Dredd is necessary to provide immunity to reactive oxygen species-resistant pathogens.
dsRNA made from templates generated with primers directed against this gene stops cleavage of the Rel protein product in mbn-2 and S2 cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutation in Dredd renders flies highly susceptible to infection by Gram-negative bacteria.
"Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision.
"Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision.