FlyBase Allele Report: Dmel\Dredd[L23]

General Information

Symbol

Dmel\Dredd^L23

Species

D. melanogaster

Name

FlyBase ID

FBal0120961

Feature type

allele

Associated gene

Dmel\Dredd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Leulier et al., 2000)

Mutagen

ethyl methanesulfonate

(Leulier et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: W458R.

(Leulier et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:633,948..633,948 [-]

Nucleotide change:

T633948A

Amino acid change:

W430R | Dredd-PD; W436R | Dredd-PE; W382R | Dredd-PG

Reported amino acid change:

W458R

Comment:

The predicted amino acid change was reported relative to a 516aa Dredd protein, which would be created by the use of an uptream translation start. The current Dredd genome annotation uses a downstream AUG which is supported by both species conservation and RNA-seq data. The two start sites are 22 aa apart.

(Leulier, 2019.9.22, Leulier et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Meinander et al., 2012)

abnormal immune response | adult stage

(Aalto et al., 2019)

short lived | conditional

(Aalto et al., 2019)

viable

(Leulier et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dredd^L23 individuals are sensitive to Ecc15 bacterial infection via feeding or septic injury.

(Aalto et al., 2019)

Mutant flies show greatly reduced survival compared to wild type after septic injury with Erwinia carotovora carotovora 15.

(Meinander et al., 2012)

Dredd^L23 homozygotes exhibit wild-type apoptosis of vCrz neurons, with no viable vCrz neurons detected at 7 hours after puparium formation.

(Lee et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Dredd[+]/Dredd^L23 is a non-enhancer of visible phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Suppressor of

Statement

Reference

Dredd^L23 is a suppressor of abnormal cell death phenotype of Dronc^I24/Dronc⁵¹

(Lee et al., 2011)

NOT Suppressor of

Statement

Reference

Dredd[+]/Dredd^L23 is a non-suppressor of visible phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Dredd[+]/Dredd^L23 is a non-enhancer of microchaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Dredd[+]/Dredd^L23 is a non-enhancer of macrochaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Suppressor of

Statement

Reference

Dredd^L23 is a suppressor of neuron phenotype of Dronc^I24/Dronc⁵¹

(Lee et al., 2011)

NOT Suppressor of

Statement

Reference

Dredd[+]/Dredd^L23 is a non-suppressor of microchaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Dredd[+]/Dredd^L23 is a non-suppressor of macrochaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

Dredd^L23/Dredd^L23 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Moreno et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

No viable vCrz neurons are detected at 7 hours after puparium formation in Dredd^L23; Nc^I24/Nc⁵¹ double mutants.

(Lee et al., 2011)

Homozygosity for Dredd^L23 does not supress the ablation of adult eye tissue seen in egr^Scer\UAS.cMa; Scer\GAL4^GMR.PF animals.

(Moreno et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99693

y¹ w^* Dredd^L23

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dredd^L23

(Meinander et al., 2012, Suissa et al., 2011)

L23

(Leulier, 2019.9.22, Leulier et al., 2000)

dredd^L23

(Aalto et al., 2019, Lee et al., 2011, Balakireva et al., 2006, Moreno et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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