FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Dark, Dredd
FlyBase ID
FBig0000106912
Interaction Network
Interactions Browser links
Dark network
Dredd network
Reported Interactions
FBrf0129865-3.coIP.WB
Reference
Hu and Yang, 2000
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Dark 

DARK

bait

FLAG tag

Dredd 

DREDD

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Fadd interacts with Dredd strongly and with Dark weakly.

(Hu and Yang, 2000)

Source was cell extract of 293 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Hu and Yang, 2000)
FBrf0129865-4.coIP.WB
Reference
Hu and Yang, 2000
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Dredd 

DREDD

bait

FLAG tag

Dredd 
Dredd 
Dark 

DARK

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Dredd 
caspase domain
sufficient binding region
aa 239-494

"casp" construct, weak, coordinates relative to Dredd-PA

Dredd 
death-inducing domain
sufficient binding region
aa 1-239

"pro" construct, coordinates relative to Dredd-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of 293 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Hu and Yang, 2000)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)