FlyBase Allele Report: Dmel\Dredd[HMS00063]

General Information

Symbol

Dmel\Dredd^HMS00063

Species

D. melanogaster

Name

FlyBase ID

FBal0263083

Feature type

allele

Associated gene

Dmel\Dredd

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00063}

Also Known As

UAS-Dredd-RNAi, UAS-Dredd^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00063}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00063

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Han et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^ap-md544

(Shinoda et al., 2019)

Phenotype Manifest In

wing, with Scer\GAL4^ap-md544

(Shinoda et al., 2019)

Detailed Description

Statement

Reference

The expression of Dredd^HMS00063 under the control of Scer\GAL4^ap-md544, with or without Dicer-2 (for a more efficient RNAi), leads to wings that are curled downward, but not opaque, which indicates growth inhibition during development but not apoptosis, respectively.

(Shinoda et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Dredd^HMS00063, Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of egg chamber | increased number phenotype of Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)