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General Information
Name
CASPASES
Species
D. melanogaster
Symbol
CASP
FlyBase ID
FBgg0000100
Date last reviewed
2020-06-08
Number of members
7
Description
Description
Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. Caspases belong to MEROPS family C14. (Adapted from FBrf0215539).
Notes on Group

Dronc is the initiator caspase subunit of the apoptosome complex.

Source Material
The CASPASES Gene Group has been compiled by FlyBase curators using the following publication(s): Xu et al., 2009, Harvey et al., 2001, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Parent group(s)
Protein Complex group(s)
Other related group(s)
Members (7)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Death associated molecule related to Mch2 caspase
Daydream, Death associated molecule related to Mch2
Death executioner caspase related to Apopain/Yama
caspase-3, Caspase 3, Casp3, Cas3, CC3
Death related ced-3/Nedd2-like caspase
Dcp-2/Dredd, Dcp-2, EG:115C2.9, Dcp2
Death regulator Nedd2-like caspase
Nc, Nedd2-like caspase, caspase-9
Ser/Thr-rich caspase
dream, Strica/Dream, Dream/Strica
External Data
Other resource(s)

[MEROPS Family C14](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c14)

Synonyms and Secondary IDs
Synonym(s)
CASP
Cysteine-dependent aspartyl-specific protease
CASPASES
CASPASE
Secondary FlyBase ID(s)
References (5)