FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cysteine-type endopeptidase activity ID (Ontology) GO:0004197 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Also Known As "thiol endopeptidase activity"
Comment
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 cysteine-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cysteine-type endopeptidase activity       --
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peptidase activity
 |__endopeptidase activity____________
 |__cysteine-type peptidase activity__|
                                      cysteine-type endopeptidase activity  30 rec.
                                       |__calcium-dependent cysteine-type endopeptidase activity 4 rec.
                                       |__GPI-anchor transamidase activity 3 rec.
                                       |__ubiquitin-like protein-specific endopeptidase activity 2 rec.
                                           |__SUMO-specific endopeptidase activity 2 rec.
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Is a endopeptidase activity
cysteine-type peptidase activity
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Synonyms
  • "caspase activity" NARROW
    "lysosomal cysteine-type endopeptidase" NARROW
    "metacaspase activity" NARROW
    "thiol endopeptidase activity" EXACT
Secondary IDs
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EC:3.4.22.-
EC:3.4.22.1
EC:3.4.22.14
EC:3.4.22.15
EC:3.4.22.16
EC:3.4.22.27
EC:3.4.22.28
EC:3.4.22.34
EC:3.4.22.38
EC:3.4.22.40
EC:3.4.22.41
EC:3.4.22.8
MetaCyc:3.4.22.1-RXN
MetaCyc:3.4.22.14-RXN
MetaCyc:3.4.22.15-RXN
MetaCyc:3.4.22.16-RXN
MetaCyc:3.4.22.27-RXN
MetaCyc:3.4.22.34-RXN
MetaCyc:3.4.22.38-RXN
MetaCyc:3.4.22.40-RXN
MetaCyc:3.4.22.41-RXN
Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome"
Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9"
Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome"
Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle"
Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage"
Reactome:R-HSA-139952 "Caspase-8 processing in the DISC"
Reactome:R-HSA-1678920 "TLR processing at low pH"
Reactome:R-HSA-1678981 "TLR9 processing at neutral pH"
Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1"
Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta"
Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin"
Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1"
Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin"
Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)"
Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau"
Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus"
Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3"
Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1"
Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin"
Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1"
Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2"
Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha"
Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3"
Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3"
Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1"
Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin"
Reactome:R-HSA-202947 "Caspase mediated cleavage of APC"
Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1"
Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55"
Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin"
Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin"
Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3"
Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)"
Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212"
Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta"
Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22"
Reactome:R-HSA-2130349 "Generation of CLIP from lip10"
Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10"
Reactome:R-HSA-2130706 "MHC class II antigen processing"
Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex"
Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A"
Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1"
Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC"
Reactome:R-HSA-350158 "LGMN hydrolyzes GC, releasing CUBN and 25(OH)D"
Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)"
Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)"
Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK"
Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk"
Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2"
Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin"
Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2"
Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31"
Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3"
Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1"
Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin"
Reactome:R-HSA-352268 "Cleavage of Satb1"
Reactome:R-HSA-418845 "Activation of caspase-3"
Reactome:R-HSA-418846 "Caspase cleavage of UNC5A"
Reactome:R-HSA-418852 "Caspase cleavage of UNC5B"
Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1"
Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8"
Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases"
Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor"
Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4"
Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4"
Reactome:R-HSA-6800797 "The PIDDosome activates CASP2"
Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin"
Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37"
Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex"
Reactome:R-HSA-933532 "Processing of caspases"
Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"
Reactome:R-HSA-9647632 "CASP3 cleaves GSDME"
Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD"
Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins"
Reactome:R-HSA-9684273 "3CLp cleaves pp1a"
Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11"
Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4"
Reactome:R-HSA-9684336 "nsp1-4 cleaves itself"
Reactome:R-HSA-9684340 "3CLp cleaves pp1ab"
Reactome:R-HSA-9684351 "pp1a cleaves itself"
Reactome:R-HSA-9684352 "nsp3-4 cleaves itself"
Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD"
Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8"
Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8"
Reactome:R-HSA-9694338 "nsp1-4 cleaves itself"
Reactome:R-HSA-9694377 "pp1a cleaves itself"
Reactome:R-HSA-9694441 "3CLp cleaves pp1a"
Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11"
Reactome:R-HSA-9694601 "nsp3-4 cleaves itself"
Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4"
Reactome:R-HSA-9694732 "3CLp cleaves pp1ab"
Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)"
Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1"
Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3"
Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12"
Reactome:R-HSA-9792568 "CTSL1 cleaves proHPSE"
Reactome:R-HSA-9947849 "CASP5 autocatalysis on LPS micelles"
Reactome:R-HSA-9947861 "CASP4 autocatalysis on LPS micelles"
Reactome:R-HSA-9947908 "CASP4 autocatalysis on the bacterial surface"
Reactome:R-HSA-9947978 "CASP5 cleaves IL18 at D36"
Reactome:R-HSA-9947987 "CASP4 cleaves IL18 at D36"
Reactome:R-HSA-9947997 "CASP5 cleaves GSDMD"
Reactome:R-HSA-9948146 "CASP4 cleaves GSDMD"
Reactome:R-HSA-9956714 "CASP1 cleaves GBP1"
Reactome:R-HSA-9958657 "CASP4 cleaves IL1B at D27"
Reactome:R-HSA-9960522 "CASP5 cleaves IL1B at D27"
Reactome:R-HSA-9960526 "CASP4 cleaves IL1B at D116"