FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cysteine-type peptidase activity ID (Ontology) GO:0008234 (Gene Ontology)
Definition Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 cysteine-type peptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cysteine-type peptidase activity       --
 NOT | enables | cysteine-type peptidase activity       --
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hydrolase activity_______________________
catalytic activity, acting on a protein__|
                                         peptidase activity
                                          |__cysteine-type peptidase activity  104 rec.
                                              |__cysteine-type deNEDDylase activity 2 rec.
                                              |__cysteine-type deubiquitinase activity 47 rec.
                                              |   |__Met1-linked polyubiquitin deubiquitinase activity 1 rec.
                                              |__cysteine-type endopeptidase activity 30 rec.
                                              |   |__calcium-dependent cysteine-type endopeptidase activity 4 rec.
                                              |   |__GPI-anchor transamidase activity 3 rec.
                                              |   |__ubiquitin-like protein-specific endopeptidase activity(+) 2 rec.
                                              |__cysteine-type exopeptidase activity 7 rec.
                                              |   |__cysteine-type aminopeptidase activity 5 rec.
                                              |   |__cysteine-type carboxypeptidase activity
                                              |__deSUMOylase activity 5 rec.
                                              |__deUFMylase activity 3 rec.
                                              |__gamma-glutamyl-peptidase activity 3 rec.
                                              |__ISG15-specific peptidase activity
                                              |__pyroglutamyl-peptidase activity 2 rec.
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Is a peptidase activity
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Synonyms
  • "cysteine protease activity" NARROW
    "thiol protease activity" NARROW
Secondary IDs
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Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))"
Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)"
Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin"
Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA"
Reactome:R-HSA-9757951 "CASP8 cleaves N4BP1 at D424, D490"