FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\dnr1
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General Information
Symbol
Dmel\dnr1
Species
D. melanogaster
Name
defense repressor 1
Annotation Symbol
CG12489
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260866
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
58E9-58F1
Sequence location
Recombination map
2-100
RefSeq locus
NT_033778 REGION:22563152..22592964
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from sequence or structural similarity with UniProtKB:Q8WY64
(Gene Ontology Curators, 2002-)
enables ubiquitin-protein transferase activity
inferred from biological aspect of ancestor with PANTHER:PTN001150528
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in negative regulation of antibacterial peptide biosynthetic process
inferred from mutant phenotype
(Cao et al., 2013)
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from mutant phenotype
(Guntermann et al., 2009)
involved_in negative regulation of peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Cao et al., 2013, Guntermann et al., 2009, Foley and O'Farrell, 2004)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from direct assay
(Guntermann et al., 2009)
involved_in sleep
inferred from mutant phenotype
(Harbison and Sehgal, 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in protein ubiquitination
inferred from sequence or structural similarity with UniProtKB:Q8WY64
(Gene Ontology Curators, 2002-)
involved_in ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001150528
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. [Date last reviewed: 2019-02-28]
Gene Group (FlyBase)
UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -
This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.
Pathway (FlyBase)
NEGATIVE REGULATORS OF IMD SIGNALING PATHWAY -
Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\dnr1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KFY0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dnr1-RA
FBtr0071837
NM_137836
3194
676
dnr1-RB
FBtr0330229
NM_001274208
3553
696
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dnr1-PA
FBpp0071748
73.2
676
7.83
Q8SWW8
NP_611680
AAF46858
dnr1-PB
FBpp0303262
75.5
696
7.80
A0A0B4KFY0
NP_001261137
AGB93668
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dnr1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.36

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dnr1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dnr1
Transgenic constructs containing regulatory region of dnr1
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)Exel7174
(Ryder, 2004.4.26)
Df(2R)X58-12
(Cao et al., 2013)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (34)
Hsap\MYLIP
12 of 14
Yes
Yes
Hsap\BIRC2
2 of 14
No
No
Hsap\BIRC3
2 of 14
No
No
Hsap\BIRC7
2 of 14
No
No
1  
Hsap\BIRC8
2 of 14
No
No
Hsap\XIAP
2 of 14
No
No
1  
Hsap\BIRC5
1 of 14
No
No
Hsap\BIRC6
1 of 14
No
No
Hsap\CYHR1
1 of 14
No
No
Hsap\EPB41
1 of 14
No
No
Hsap\EPB41L1
1 of 14
No
No
Hsap\EPB41L2
1 of 14
No
No
1  
Hsap\EPB41L3
1 of 14
No
No
Hsap\EPB41L4A
1 of 14
No
No
Hsap\EPB41L4B
1 of 14
No
No
Hsap\EPB41L5
1 of 14
No
No
Hsap\EZR
1 of 14
No
No
1  
Hsap\FARP1
1 of 14
No
No
Hsap\FARP2
1 of 14
No
No
Hsap\FRMD3
1 of 14
No
No
Hsap\FRMD5
1 of 14
No
No
7  
Hsap\FRMD7
1 of 14
No
No
Hsap\MIB1
1 of 14
No
No
6  
Hsap\MSN
1 of 14
No
No
Hsap\NAIP
1 of 14
No
No
Hsap\NF2
1 of 14
No
No
10  
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN14
1 of 14
No
No
Hsap\PTPN21
1 of 14
No
No
Hsap\RDX
1 of 14
No
No
1  
Hsap\RFFL
1 of 14
No
No
Hsap\SIAH1
1 of 14
No
No
1  
Hsap\SIAH2
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (22)
Rnor\Mylip
12 of 14
Yes
Yes
Rnor\Birc2
2 of 14
No
No
Rnor\Birc3
2 of 14
No
No
Rnor\Birc7
2 of 14
No
No
Rnor\Cyhr1
1 of 14
No
No
Rnor\Epb41l1
1 of 14
No
No
Rnor\Epb41l2
1 of 14
No
No
Rnor\Epb41l3
1 of 14
No
No
Rnor\Epb41l4b
1 of 14
No
No
Rnor\Epb41l5
1 of 14
No
No
Rnor\Epb41
1 of 14
No
No
Rnor\Ezr
1 of 14
No
No
Rnor\Farp1
1 of 14
No
No
Rnor\Farp2
1 of 14
No
No
Rnor\Frmd5
1 of 14
No
No
Rnor\Msn
1 of 14
No
No
Rnor\Ptpn3
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Rdx
1 of 14
No
No
Rnor\Siah1
1 of 14
No
No
Rnor\Siah2
1 of 14
No
No
Rnor\Xiap
1 of 14
No
No
Mus musculus (laboratory mouse) (23)
Mmus\Mylip
12 of 14
Yes
Yes
Mmus\Birc2
2 of 14
No
No
Mmus\Birc3
2 of 14
No
No
Mmus\Birc7
1 of 14
No
No
Mmus\Cyhr1
1 of 14
No
No
Mmus\Epb41l1
1 of 14
No
No
Mmus\Epb41l2
1 of 14
No
No
Mmus\Epb41l3
1 of 14
No
No
Mmus\Epb41l4b
1 of 14
No
No
Mmus\Epb41l5
1 of 14
No
No
Mmus\Epb41
1 of 14
No
No
Mmus\Ezr
1 of 14
No
No
Mmus\Farp2
1 of 14
No
No
Mmus\Frmd3
1 of 14
No
No
Mmus\Frmd5
1 of 14
No
No
Mmus\Frmd7
1 of 14
No
No
Mmus\Msn
1 of 14
No
No
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Rdx
1 of 14
No
No
Mmus\Siah1a
1 of 14
No
No
Mmus\Siah2
1 of 14
No
No
Mmus\Xiap
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\mylip
10 of 13
Yes
Yes
Xtro\LOC101731001
8 of 13
No
Yes
Xtro\birc2
2 of 13
No
No
Xtro\birc7
2 of 13
No
No
Xtro\xiap
2 of 13
No
No
Xtro\birc5l
1 of 13
No
No
Xtro\birc5
1 of 13
No
No
Xtro\birc6
1 of 13
No
No
Xtro\epb41l3
1 of 13
No
No
Xtro\farp1
1 of 13
No
No
Xtro\frmd3
1 of 13
No
No
Xtro\frmd7
1 of 13
No
No
Xtro\LOC101733194
1 of 13
No
No
Xtro\LOC116406436
1 of 13
No
No
Xtro\mib1
1 of 13
No
No
Xtro\ptpn21
1 of 13
No
No
Xtro\siah1
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\mylipa
13 of 14
Yes
Yes
Drer\mylipb
12 of 14
No
Yes
Drer\birc2
2 of 14
No
No
Drer\birc7
2 of 14
No
No
Drer\cyhr1
1 of 14
No
No
Drer\epb41b
1 of 14
No
No
Drer\epb41l3a
1 of 14
No
No
Drer\epb41l4a
1 of 14
No
No
Drer\epb41l5
1 of 14
No
No
Drer\ezra
1 of 14
No
No
Drer\ezrb
1 of 14
No
No
Drer\farp1
1 of 14
No
No
Drer\farp2
1 of 14
No
No
Drer\frmd5b
1 of 14
No
No
Drer\frmd7
1 of 14
No
No
Drer\LOC557811
1 of 14
No
No
Drer\LOC570903
1 of 14
No
No
Drer\msna
1 of 14
No
No
Drer\ptpn3
1 of 14
No
No
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\si:dkey-178k16.1
1 of 14
No
No
Drer\siah1
1 of 14
No
No
Drer\siah2l
1 of 14
No
No
Drer\xiap
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\nfm-1
2 of 14
Yes
No
Cele\erm-1
1 of 14
No
No
Cele\frm-1
1 of 14
No
No
Cele\frm-2
1 of 14
No
No
Cele\frm-3
1 of 14
No
No
Cele\frm-4
1 of 14
No
No
Cele\ptp-1
1 of 14
No
No
Cele\siah-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (21)
Agam\AgaP_AGAP001609
12 of 12
Yes
Yes
Agam\AgaP_AGAP012677
2 of 12
No
No
Agam\AgaP_AGAP012751
2 of 12
No
Yes
Agam\IAP1
2 of 12
No
No
Agam\IAP2
2 of 12
No
No
Agam\IAP3
2 of 12
No
No
Agam\IAP4
2 of 12
No
No
Agam\IAP7
2 of 12
No
No
Agam\AgaP_AGAP001287
1 of 12
No
No
Agam\AgaP_AGAP001632
1 of 12
No
No
Agam\AgaP_AGAP002264
1 of 12
No
No
Agam\AgaP_AGAP002651
1 of 12
No
No
Agam\AgaP_AGAP004136
1 of 12
No
No
Agam\AgaP_AGAP007130
1 of 12
No
No
Agam\AgaP_AGAP008811
1 of 12
No
No
Agam\AgaP_AGAP009975
1 of 12
No
No
Agam\AgaP_AGAP010346
1 of 12
No
No
Agam\AgaP_AGAP012185
1 of 12
No
No
Agam\IAP5
1 of 12
No
No
Agam\IAP8
1 of 12
No
No
Agam\MOEH_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\APD3
1 of 13
Yes
No
Atha\APD4
1 of 13
Yes
No
Atha\AT5G23110
1 of 13
Yes
Yes
Atha\LUL2
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CSS1
1 of 13
Yes
Yes
Scer\HPF1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dnr1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
cora
3 of 13
Frmd5
3 of 13
yrt
3 of 13
CG34347
2 of 13
Diap1
2 of 13
Diap2
2 of 13
Bruce
1 of 13
Cdep
1 of 13
CG17019
1 of 13
CG32486
1 of 13
Mer
1 of 13
Moe
1 of 13
Pez
1 of 13
Ptpmeg
1 of 13
sinah
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    dnr12-133
    model of  neurodegenerative disease
    CEA
    (Cao et al., 2013)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    dnr12-133
    model of  neurodegenerative disease
    is ameliorated by RelE20
    (Cao et al., 2013)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MYLIP; myosin regulatory light chain interacting protein
    12 of 14
    610082
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        dnr1 - Dredd
        anti tag coimmunoprecipitation, anti tag western blot
        (Guntermann et al., 2009)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dnr1
        suppressible
        Rel
        (Cao et al., 2013)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-100
        Cytogenetic map
        58E9-58F1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        58E9-58F1
        Limits computationally determined from genome sequence between P{lacW}l(2)k13211k13211&P{EP}EP827 and P{PZ}l(2)rG270rG270
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-100

        (FlyBase, 2016)

        2-105.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (16)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (29)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           

          • New stable cell line derived from S2-unspecified : A stable S2 cell line that constitutively expresses an Tag:HA-tagged Dredd variant in which the active site cysteine has been replaced with an alanine (HADreddC408A) were created. Stable S2 cell lines that constitutively express Tag:HA-tagged wild type or mutant dnr1 in which the essential RING domain active site cysteine was replaced with a tyrosine were also created (HADnr1 and HADnr1C563Y).

            (Guntermann et al., 2009)
          Other Comments

          Identification: In RNAi screen for innate immunity regulators.

          (Foley and O'Farrell, 2004)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Dnr1 dnr1

          (FlyBase, 1992-)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: dnr1 CG12489

          (Foley, 2004.2.24)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (10)
          Reported As
          Symbol Synonym
          CG12489
          (National Institute of Genetics Fly Stocks, 2022-, Lin et al., 2015, Ying et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Gonzalez-Aguero et al., 2005, Huet et al., 2002, Robertson, 2001.5.6)
          DNR1
          (Riahi et al., 2021, Kleino and Silverman, 2014, Fukuyama et al., 2013)
          Dnr-1
          (Myllymäki et al., 2014)
          Dnr1
          (Cammarata-Mouchtouris et al., 2022, Kumar et al., 2021, Abnave et al., 2014, Ashwal-Fluss et al., 2014, Valanne, 2014, Han et al., 2013, Igboin et al., 2012, Carreira et al., 2011, Jungreis et al., 2011, Valanne et al., 2011, Anholt and Williams, 2010, Hill-Burns and Clark, 2010, Kong et al., 2010, Magwire et al., 2010, Guntermann et al., 2009)
          Mylip
          (Cahill et al., 2021)
          dNR1
          (Huang et al., 2020, Allada et al., 2017)
          defense repressor 1
          (Anonymous, 2005)
          dnr1
          (Pan et al., 2023, Pavlidaki et al., 2022, Dewett et al., 2021, Arora and Ligoxygakis, 2020, Shaposhnikov et al., 2020, Engel et al., 2019, Stobdan et al., 2019, Early et al., 2017, Ketosugbo et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Kavi et al., 2015, Jalvingh et al., 2014, Pézeron et al., 2014, Stern et al., 2014, Cao et al., 2013, Lavagnino et al., 2013, Sen et al., 2013, Du et al., 2011, Kong et al., 2010, Primrose et al., 2007, Foley and O'Farrell, 2004)
          Name Synonyms
          Defense repressor 1
          (Magwire et al., 2010, Primrose et al., 2007, Foley and O'Farrell, 2004)
          Defense repressor I
          (Harbison and Sehgal, 2008)
          defense repressor 1
          (Cao et al., 2013, Fukuyama et al., 2013, Foley and O'Farrell, 2004)
          dnr1
          Secondary FlyBase IDs
          • FBgn0034738
          • FBgn0084288
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 50 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (94)