FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ubiquitin-dependent protein catabolic process ID (Ontology) GO:0006511 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
Also Known As"ubiquitin-dependent protein breakdown" ; "ubiquitin-dependent protein catabolism" ; "ubiquitin-dependent protein degradation" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 ubiquitin-dependent protein catabolic process (all annotations which use CV term, excluding "NOT" statements)
     involved_in | ubiquitin-dependent protein catabolic process       --
Spanning Tree (Parents/Children)
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Vocabulary search 
protein catabolic process_______________________________
modification-dependent macromolecule catabolic process__|
                                                        modification-dependent protein catabolic process
                                                         |__ubiquitin-dependent protein catabolic process  369 rec.
                                                             |__proteasome-mediated ubiquitin-dependent protein catabolic process 285 rec.
                                                             |   |__anaphase-promoting complex-dependent catabolic process(+) 19 rec.
                                                             |   |__cytoplasm protein quality control by the ubiquitin-proteasome system
                                                             |   |__mitochondria-associated ubiquitin-dependent protein catabolic process
                                                             |   |__negative regulation of transcription by transcription factor catabolism
                                                             |   |__nuclear protein quality control by the ubiquitin-proteasome system(+) 1 rec.
                                                             |   |__RADAR pathway
                                                             |   |__regulation of proteasomal ubiquitin-dependent protein catabolic process(+) 60 rec.
                                                             |   |__ribosome-associated ubiquitin-dependent protein catabolic process(+) 4 rec.
                                                             |   |__SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(+) 69 rec.
                                                             |   |__stress-induced homeostatically regulated protein degradation pathway
                                                             |   |__ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 2 rec.
                                                             |   |__ubiquitin-dependent protein catabolic process via the N-end rule pathway 5 rec.
                                                             |__protein arginylation
                                                             |__protein deubiquitination involved in ubiquitin-dependent protein catabolic process 1 rec.
                                                             |__regulation of ubiquitin-dependent protein catabolic process 74 rec.
                                                             |   |__negative regulation of ubiquitin-dependent protein catabolic process(+) 17 rec.
                                                             |   |__positive regulation of ubiquitin-dependent protein catabolic process(+) 53 rec.
                                                             |   |__regulation of proteasomal ubiquitin-dependent protein catabolic process(+) 60 rec.
                                                             |__ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 14 rec.
                                                                 |__protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 6 rec.
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Is a modification-dependent protein catabolic process
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Synonyms
  • "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW
    "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW
    "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW
    "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW
    "protein degradation tagging activity" BROAD
    "protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW
    "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED
    "protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW
    "protein ubiquitination during ubiquitin-dependent protein degradation" NARROW
    "protein ubiquitination involved in ubiquitin-dependent protein catabolic process" RELATED
    "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW
    "protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW
    "protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW
    "protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW
    "ubiquitin-dependent protein breakdown" EXACT
    "ubiquitin-dependent protein catabolism" EXACT
    "ubiquitin-dependent protein degradation" EXACT
    "ubiquitin-dependent proteolysis" EXACT
Secondary IDs
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