FlyBase Gene Report: Dmel\cora

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\cora

General Information

Symbol

Dmel\cora

Species

D. melanogaster

Name

coracle

Annotation Symbol

CG11949

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010434

Gene Model Status

Stock Availability

18 publicly available

Gene Summary

An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development. (UniProt, Q9V8R9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

Cor, D4.1, CoraC, l(2)k08713

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:19,229,063..19,243,751 [+]

Recombination map

2-88

RefSeq locus

NT_033778 REGION:19229063..19243751

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables actin binding

inferred from electronic annotation with InterPro:IPR008379

(InterPro Project Members, 2004-)

enables structural molecule activity

inferred from electronic annotation with InterPro:IPR008379

(InterPro Project Members, 2004-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in adult somatic muscle development

inferred from mutant phenotype

(Schnorrer et al., 2010)

involved_in cell adhesion involved in heart morphogenesis

inferred from mutant phenotype

(Yi et al., 2008)

involved_in dorsal closure

inferred from mutant phenotype

(Yi et al., 2008)

involved_in embryo development ending in birth or egg hatching

inferred from mutant phenotype

(Fehon et al., 1994)

involved_in establishment of glial blood-brain barrier

inferred from mutant phenotype

(Stork et al., 2008)

involved_in heart process

inferred from mutant phenotype

(Yi et al., 2008)

involved_in maintenance of imaginal disc-derived wing hair orientation

inferred from mutant phenotype

(Venema et al., 2004)

involved_in regulation of tube size, open tracheal system

inferred from mutant phenotype

(Paul et al., 2003)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in actomyosin structure organization

inferred from biological aspect of ancestor with PANTHER:PTN008596437

(GO Reference Genome Project, 2011-)

involved_in cell-cell junction organization

traceable author statement

(Harden, 2002)

involved_in dorsal closure

traceable author statement

(Noselli and Agnes, 1999)

involved_in protein targeting to membrane

traceable author statement

(Cereijido et al., 2003)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Yi et al., 2008)

located_in septate junction

inferred from direct assay

(Hall et al., 2014)

inferred from direct assay

(Fehon et al., 1994)

located_in smooth septate junction

inferred from direct assay

(Izumi et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN008596437

(GO Reference Genome Project, 2011-)

located_in cytoskeleton

inferred from electronic annotation with InterPro:IPR008379

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000589691

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.

(UniProt, Q9V8R9)

Summary (Interactive Fly)

protein 4.1 homolog - links transmembrane proteins to cytoskeleton - component of septate junctions, structures that serve as selective-permeability barriers - occluding junctions shape the signaling environment between the soma and the germline in order to maintain niche homeostasis

Interactive Fly

Gene Model and Products

Number of Transcripts

6

Number of Unique Polypeptides

6

Please see the JBrowse view of Dmel\cora for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V8R9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0086509

5899

1698

FBtr0086508

3472

889

FBtr0086506

2914

703

FBtr0301279

2902

699

FBtr0340468

5605

1600

FBtr0340469

5893

1696

Additional Transcript Data and Comments

Reported size (kB)

6.3, 3.6, 2.9 (northern blot)

(Fehon et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0085697

184.2

1698

9.17

FBpp0085696

98.0

889

6.81

FBpp0085694

78.2

703

7.99

FBpp0290494

77.8

699

8.74

FBpp0309410

173.9

1600

9.27

FBpp0309411

183.9

1696

9.17

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1698 (aa)

(Fehon et al., 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cora using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cora_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.60

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

larval foregut atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

larval foregut atrium

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

third instar larval stage

embryonic/larval neuromuscular junction

(Gardiol and St Johnston, 2014)

(Gardiol and St Johnston, 2014)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

Comment: reference states 4-20 hr AEL

(Fehon et al., 1994)

embryonic stage 12 -- 17

Comment: reference states 8-20 hr AEL

(Fehon et al., 1994)

(Fehon et al., 1994)

first instar larval stage

(Fehon et al., 1994)

second instar larval stage

(Fehon et al., 1994)

Additional Descriptive Data

cora mRNA localizes in a rim around the boutons of the neuromuscular junction.

(Gardiol and St Johnston, 2014)

The 6.3kb cora transcript is first detected in 4-8hr embryos, is much more abundant in 8-12hr embyros and remains prevalent through embryonic and larval stages.

(Fehon et al., 1994)

The 3.6kb cora transcript is first detected in 8-12hr embryos and is detected through the remaining embryonic and early larval stages.

(Fehon et al., 1994)

The 2.9kb cora transcript is first detected in 8-12hr embryos and is detected through the remaining embryonic and early larval stages.

(Fehon et al., 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

embryonic/larval foregut

(Fehon et al., 1994)

(Fehon et al., 1994)

embryonic/larval hindgut

(Fehon et al., 1994)

embryonic stage 13 -- 17

abdominal 1 lateral pentascolopidial chordotonal organ lch5 -- abdominal 7 lateral pentascolopidial chordotonal organ lch5 | precursor

(Fehon et al., 1994)

embryonic/larval salivary gland

(Fehon et al., 1994)

(Fehon et al., 1994)

chordotonal organ

(Fehon et al., 1994)

embryonic/larval tracheal section

(Fehon et al., 1994)

embryonic stage 16

epithelial cell of embryonic/larval salivary gland

• septate junction

(Paul et al., 2003)

larval tracheocyte

• septate junction

(Paul et al., 2003)

• septate junction

(Paul et al., 2003)

embryonic/larval hindgut

• basolateral plasma membrane | apical of septate junction

(Syed et al., 2011)

larval stage & pupal stage

eye-antennal disc

(Fehon et al., 1994)

(Fehon et al., 1994)

third instar larval stage

embryonic/larval neuromuscular junction

(Gardiol and St Johnston, 2014)

Comment: postsynaptic side

(Gardiol and St Johnston, 2014)

larval glial cell

(Gardiol and St Johnston, 2014)

embryonic/larval tracheal section

(Gardiol and St Johnston, 2014)

embryonic/larval copper cell

(Phillips and Thomas, 2006)

adult stage | female & oogenesis

(Vachias et al., 2014)

oogenesis stage S5 -- S6 & adult stage | female

follicle cell | lateral

(Ng et al., 2016)

oogenesis stage S7 -- S8 & adult stage | female

follicle cell | apical | lateral

(Ng et al., 2016)

• plasma membrane

(de Cuevas et al., 1996)

germarium cap cell

• plasma membrane

(de Cuevas et al., 1996)

terminal filament

• plasma membrane

(de Cuevas et al., 1996)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

Additional Descriptive Data

cora localizes on the postsynaptic side of boutons in third instar larval neuromuscular junctions.

(Gardiol and St Johnston, 2014)

cora protein is expressed in a short apical stretch of the basolateral membrane of embryonic septate junctions in the embryonic hindgut.

(Syed et al., 2011)

Marker for

septate junction

(Fairchild et al., 2015, Bätz et al., 2014)

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Yi et al., 2008)

located_in septate junction

inferred from direct assay

(Hall et al., 2014)

inferred from direct assay

(Fehon et al., 1994)

located_in smooth septate junction

inferred from direct assay

(Izumi et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cora in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cora

View exonic expression by tissue for Dmel\cora

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010434

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37205/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010434

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010434

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010434

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11949

Flygut - An atlas of the Drosophila adult midgut

FBgn0010434

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\cora

Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cora

Transgenic constructs containing regulatory region of cora

Aberrations (Deficiencies and Duplications) ( 9 )

Inferred from experimentation ( 9 )

Gene disrupted in

(Chen et al., 2005)

(Lamb et al., 1998)

(Bradley and Andrew, 2001, Lamb et al., 1998, Gertler et al., 1995)

Df(2R)EP2445^Δ1

(Bradley and Andrew, 2001)

(Ryder, 2004.4.26)

(Bradley and Andrew, 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Shim et al., 2001)

Gene not disrupted in

(Bradley and Andrew, 2001)

(Bradley and Andrew, 2001)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | partially | recessive | somatic clone

cora⁴

lethal, with Scer\GAL4^C57

cora^GD1405

lethal, with Scer\GAL4^how-24B

cora^GD1405

lethal | maternal effect, with Scer\GAL4^c355

cora^HMC03418

lethal | recessive

lethal - all die before end of larval stage | recessive

cora¹⁴

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

cora^GD1405

lethal - all die during embryonic stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cora^GD1405

viable, with Scer\GAL4^tey-5053A

cora^GD1405

viable, with Scer\GAL4^tin.CΔ4

cora^GD1405

Sterility

Allele

female sterile, with Scer\GAL4^c355

cora^HMC03418

cora^EY07598

Other Phenotypes

Allele

abnormal cell polarity (with cora⁵)

cora¹⁵

abnormal cell polarity (with cora¹⁵)

cora⁵

abnormal immune response | adult stage, with Scer\GAL4^NP3084

cora^GD1405

abnormal mitotic cell cycle | P-stage, with Scer\GAL4^pnr.PU

cora^GD1405

abnormal neuroanatomy

abnormal neuroanatomy (with cora⁵)

cora^k08713

abnormal neuroanatomy (with cora^k08713)

cora⁵

abnormal neuroanatomy | third instar larval stage

cora¹⁴

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

abnormal neurophysiology

abnormal neurophysiology (with cora⁵)

cora^k08713

abnormal neurophysiology (with cora^k08713)

cora⁵

abnormal neurophysiology | third instar larval stage

cora¹⁴

flightless, with Scer\GAL4^Mef2.PR

cora^GD1405

some die during embryonic stage | recessive

some die during larval stage | recessive

cora¹⁴

some die during pupal stage, with Scer\GAL4^pnr-MD237

cora^GD1405

visible | embryonic stage | maternal effect, with Scer\GAL4^c355

cora^HMC03418

visible | recessive

cora¹⁵

Phenotype manifest in

Allele

A1-7 ventral longitudinal muscle cell | third instar larval stage

cora¹⁴

embryo | dorsal closure stage

cora⁵

embryo | embryonic stage 17, with Scer\GAL4^unspecified

cora^HMC03418

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle | dorsal

embryonic/larval cuticle | embryonic stage

cora²

embryonic/larval epidermis

cora^unspecified

embryonic/larval neuromuscular junction | third instar larval stage

cora¹⁴

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

embryonic/larval salivary gland | embryonic stage

embryonic dorsal epidermis

embryonic ganglionic branch & embryonic tracheole (with cora⁴)

cora⁵

embryonic ganglionic branch & embryonic tracheole (with cora⁵)

cora⁴

cora²

external sensory organ precursor cell | P-stage, with Scer\GAL4^pnr.PU

cora^GD1405

indirect flight muscle cell, with Scer\GAL4^Mef2.PR

cora^GD1405

interocellar bristle

interommatidial bristle

larval tracheal system | embryonic stage 17

cora¹⁴

midbody | P-stage, with Scer\GAL4^pnr.PU

cora^GD1405

myofibril, with Scer\GAL4^Mef2.PR

cora^GD1405

NMJ bouton | increased number | third instar larval stage

cora¹⁴

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^how-24B

ocellar bristle

pleated septate junction

cora⁵

presumptive embryonic/larval tracheal system

cora⁵

presumptive embryonic salivary gland

cora⁵

sarcomere, with Scer\GAL4^Mef2.PR

cora^GD1405

septate junction

cora⁵

septate junction | embryonic stage

smooth septate junction, with Scer\GAL4^NP3084

cora^GD1405

tracheal dorsal trunk primordium (with cora⁴)

cora⁵

tracheal dorsal trunk primordium (with cora⁵)

cora⁴

ventral denticle belt

cora⁵

wing hair (with cora⁵)

cora¹⁵

wing hair (with cora¹⁵)

cora⁵

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (36)

11 of 14

Yes

Yes

11 of 14

Yes

Yes

1

11 of 14

Yes

Yes

10 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

3 of 14

No

No

7

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

10

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

3

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

11 of 14

Yes

Yes

10 of 14

No

Yes

9 of 14

No

Yes

8 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

Mus musculus (laboratory mouse) (26)

11 of 14

Yes

Yes

11 of 14

Yes

Yes

9 of 14

No

Yes

9 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

3 of 14

No

No

Mmus\2310002L09Rik

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (21)

8 of 13

Yes

Yes

6 of 13

No

Yes

5 of 13

No

Yes

5 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xtro\LOC101731001

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

Danio rerio (Zebrafish) (32)

11 of 14

Yes

Yes

9 of 14

No

Yes

Drer\si:dkey-178k16.1

9 of 14

No

Yes

7 of 14

No

Yes

5 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

Drer\zgc:172136

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (16)

4 of 14

Yes

Yes

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (15)

Agam\AgaP_AGAP012185

12 of 12

Yes

Yes

Agam\AgaP_AGAP001632

2 of 12

No

No

Agam\AgaP_AGAP004136

2 of 12

No

No

Agam\AgaP_AGAP008811

2 of 12

No

No

Agam\AgaP_AGAP001109

1 of 12

No

No

Agam\AgaP_AGAP001287

1 of 12

No

No

Agam\AgaP_AGAP001609

1 of 12

No

No

Agam\AgaP_AGAP002725

1 of 12

No

No

Agam\AgaP_AGAP007130

1 of 12

No

No

Agam\AgaP_AGAP007474

1 of 12

No

No

Agam\AgaP_AGAP009126

1 of 12

No

No

Agam\AgaP_AGAP009975

1 of 12

No

No

Agam\AgaP_AGAP010346

1 of 12

No

No

Agam\AgaP_AGAP013042

1 of 12

No

No

Agam\MOEH_ANOGA

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (2)

1 of 13

Yes

Yes

1 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cora. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

inflammatory bowel disease, tight/septate junction defect

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of inflammatory bowel disease

CEA

(Bonnay et al., 2013)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

EPB41L1; erythrocyte membrane protein band 4.1 like 1

model of autosomal dominant intellectual developmental disorder 11

IEA

(FlyBase, 2019-)

EPB41; erythrocyte membrane protein band 4.1

model of hereditary elliptocytosis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EPB41L1; erythrocyte membrane protein band 4.1 like 1

11 of 14

CHROMOSOME 20q11-q12 DELETION SYNDROME

autosomal dominant intellectual developmental disorder 11

EPB41L2; erythrocyte membrane protein band 4.1 like 2

11 of 14

EPB41L3; erythrocyte membrane protein band 4.1 like 3

11 of 14

EPB41; erythrocyte membrane protein band 4.1

10 of 14

ELLIPTOCYTOSIS 1; EL1

hereditary elliptocytosis

EPB41L4B; erythrocyte membrane protein band 4.1 like 4B

3 of 14

FRMD3; FERM domain containing 3

3 of 14

FRMD5; FERM domain containing 5

3 of 14

FERM DOMAIN-CONTAINING PROTEIN 5; FRMD5

NEURODEVELOPMENTAL DISORDER WITH EYE MOVEMENT ABNORMALITIES AND ATAXIA; NEDEMA

neurodevelopmental disorder with eye movement abnormalities and ataxia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, western blot

(Bogdanik et al., 2008)

anti tag coimmunoprecipitation, western blot

(Schulte et al., 2006)

(Chen et al., 2005)

(Chen et al., 2005)

(Chen et al., 2005)

anti bait coimmunoprecipitation, western blot

(Genova and Fehon, 2003)

anti bait coimmunoprecipitation, western blot

(Genova and Fehon, 2003)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, pull down, molecular weight estimation by staining

(Lee et al., 2020)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

proximity-dependent biotin identification, Identification by mass spectrometry

(Mannix et al., 2019)

anti bait coimmunoprecipitation, western blot

(Genova and Fehon, 2003)

anti bait coimmunoprecipitation, western blot

(Genova and Fehon, 2003)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RNA-RNA

Physical Interaction

Assay

References

immunohistochemistry, luminiscence technology

(Sharifkhodaei et al., 2016, Kertesz et al., 2007)

RNA-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, reverse transcription pcr

(Song et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

suppressible

(Lamb et al., 1998, Fehon et al., 1994)

suppressible

(Bruelle et al., 2023)

suppressible

(Hudson et al., 2023)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62870

DroID - A comprehensive database of gene and protein interactions.

FBgn0010434

MIST (genetic) - An integrated Molecular Interaction Database

37205

MIST (protein-protein) - An integrated Molecular Interaction Database

37205

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-88

Cytogenetic map

Sequence location

2R:19,229,063..19,243,751 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56C4-56C4

Limits computationally determined from genome sequence between P{PZ}ena⁰²⁰²⁹&P{lacW}cora^k08713 and P{lacW}hts^k06121

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56C-56C

(Fehon, 1994.3.29)

56C1-56C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

56C-56C

(determined by in situ hybridisation)

(Fehon et al., 1994)

56C1-56C2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-88

(FlyBase, 2016)

2-94.1

(Comeron et al., 2012)

2-86.9

(Fehon et al., 1994)

Left of (cM)

wbl

(Konsolaki and Schupbach, 1998)

px

(Fehon et al., 1994)

Right of (cM)

c

(Fehon et al., 1994)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

9099

P{neoFRT}43D cora¹⁴/CyO

600489

w^*; P{UAS-myc.cora}m5-1/CyO

600491

w^*; P{UAS-FLAG.cora.GFP}3-7

600494

P{Ubi-myc.cora.1-383}m36, w^*

52232

w^*; P{neoFRT}43D cora⁴/CyO

52233

w^*; P{neoFRT}43D cora⁵/CyO

51845

y¹ v¹; P{TRiP.HMC03418}attP40

16848

y¹ w^67c23; P{EPgy2}cora^EY07598

34114

y¹ w^*; Mi{MIC}cora^MI00820/SM6a

v108749

P{KK109444}VIE-260B

v9787

w¹¹¹⁸; P{GD1405}v9787

v9788

w¹¹¹⁸; P{GD1405}v9788

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (71)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18624

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010434

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010434

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lee et al., 2020)

monoclonal

(Fehon et al., 1994)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Appears to function to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development.

(Venema et al., 2004)

Proper targetting of pck gene product to the pleated septate junctions in the tracheal system depends on Nrx-IV and cora but not Fas3.

(Behr et al., 2003)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

cora is a necessary component of the septate junction required for the maintenance of the transepithelial barrier.

(Lamb et al., 1998)

The amino-terminal 383 amino acids of cora define a functional domain that is both necessary and sufficient for proper septate junction localisation of the protein. This domain and the cytoplasmic domain of Nrx-IV interact directly.

(Ward et al., 1998)

Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.

(Woods et al., 1997)

The cora gene product is a component of neither fusomes nor spectrosomes.

(de Cuevas et al., 1996)

cora mutants die early in embryogenesis as they fail to complete dorsal closure. cora interacts genetically with Egfr^E1 and Ras85D^V12.

(Lamb and Fehon, 1995)

The cora product is associated with a septate junction and may play a role in cell-cell interactions essential for normal development.

(Fehon et al., 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: cora l(2)k08713

(Spradling et al., 1999)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: cora CG11949

(Milshina, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG11949

(Çiçek et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Shanshan and Laixin, 2015, Bonn et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Rogers et al., 2003, Ramet et al., 2002, Goldstein and Gunawardena, 2000)

COR

(Bhat, 2003, Genova and Fehon, 2003, Müller and Bossinger, 2003)

Cora

(Mira-Osuna et al., 2025, Feng et al., 2024, Shore et al., 2022, Alhadyian et al., 2021, Watson et al., 2021, Yin et al., 2021, Chen et al., 2020, Khadilkar and Tanentzapf, 2019, Skouloudaki et al., 2019, Yang et al., 2019, Flores-Benitez and Knust, 2016, Izumi et al., 2016, Ng et al., 2016, Sharifkhodaei et al., 2016, Felix et al., 2015, Flores-Benitez and Knust, 2015, Bätz et al., 2014, Abley et al., 2013, Bonn et al., 2013, Chen and Zhang, 2013, Song et al., 2013, Yanagihashi et al., 2012, Laprise and Tepass, 2011, Forster et al., 2010, Forster et al., 2010, Laplante et al., 2010, Nilton et al., 2010, Tiklová et al., 2010, Laprise et al., 2009, Yan et al., 2009, Bachmann et al., 2008, Kapelnikov et al., 2008, Kapelnikov et al., 2008, Laval et al., 2008, Liebl and Featherstone, 2008, Araujo et al., 2007, Sasaki et al., 2007)

CoraC

(Kyriazi et al., 2024, Tsap et al., 2024)

Coracle

(Sciambra and Chtarbanova, 2021, Ngo et al., 2020, Nguyen et al., 2016, Eikenes et al., 2015, Kim and McGinnis, 2011)

D4.1

(de Cuevas et al., 1996, Fares et al., 1995)

cor

(Nelson et al., 2010, Wagner et al., 2009, Wu et al., 2007, Cereijido et al., 2003, Genova and Fehon, 2003, Paul et al., 2003, Paul et al., 2003, Feiguin et al., 2001, Tepass et al., 2001, Muller, 2000, Agnes and Noselli, 1999, Konsolaki and Schupbach, 1998, Lamb et al., 1998, Noselli, 1998, Ward et al., 1998, Ward and Fehon, 1997, Woods et al., 1997, Ward and Fehon, 1996, Anonymous, 1995)

cora

(Mukherjee et al., 2025, Zechini et al., 2025, Luedke et al., 2024, Mukherjee et al., 2023, Crucianelli et al., 2022, De et al., 2022, Fic et al., 2021, Morin-Poulard et al., 2021, Onur et al., 2021, Pang et al., 2021, Rouka et al., 2021, Uçkun et al., 2021, Deng et al., 2020, Kiragasi et al., 2020, Lee et al., 2020, Pegoraro et al., 2020, Sundararajan et al., 2020, Zhao et al., 2020, Jiang et al., 2019, Li et al., 2019, Mannix et al., 2019, Xu et al., 2019, Yang and Chien, 2019, Yee et al., 2019, Zuber et al., 2019, Carvalho et al., 2018, Mortensen et al., 2018, Resnik-Docampo et al., 2017, Kuleesha et al., 2016, Ng et al., 2016, Piegholdt et al., 2016, Byri et al., 2015, Kallsen et al., 2015, Wang et al., 2015, Ashwal-Fluss et al., 2014, Chung and Andrew, 2014, Dong et al., 2014, Gardiol and St Johnston, 2014, Kim and Choe, 2014, Robbins et al., 2014, Rudrapatna et al., 2014, Vachias et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Irion, 2012, Izumi et al., 2012, Reid et al., 2012, Rodriguez et al., 2012, Shaik et al., 2012, Friedman et al., 2011, Bahri et al., 2010, Foley et al., 2010, Laprise et al., 2010, Schnorrer et al., 2010, Dworkin et al., 2009, Stork et al., 2009, Bogdanik et al., 2008, Moyer and Jacobs, 2008, Yi et al., 2008, Kertesz et al., 2007, Riedl et al., 2007, Barmina et al., 2005, Chen et al., 2005, Tonning et al., 2005)

l(2)k08713

(BDGP Project Members, 1994-1999)

mdcds_14526

(Chen and Oliver, 2014.8.15)

Name Synonyms

Coracle

(Bhattacharya et al., 2024, Markovich et al., 2024, Mira-Osuna and Borgne, 2024, Chen et al., 2023, Koehler and Huber, 2023, Alhadyian et al., 2021, Rice et al., 2021, Finegan and Bergstralh, 2020, Zhou et al., 2020, Nie et al., 2019, Stephens et al., 2018, Furuse and Izumi, 2017, Ng et al., 2016, Peterson and Krasnow, 2015, Dong et al., 2014, Kim and Choe, 2014, Abley et al., 2013, Bonnay et al., 2013, Chen and Zhang, 2013, Song et al., 2013, Sotillos et al., 2013, Gomez et al., 2012, Ile et al., 2012, Kim et al., 2012, Sen et al., 2012, Choi et al., 2011, Laplante and Nilson, 2011, Leiserson and Keshishian, 2011, Rodrigues et al., 2011, Syed et al., 2011, Tjota et al., 2011, Bahri et al., 2010, Khanna et al., 2010, Laplante et al., 2010, Nelson et al., 2010, Nilton et al., 2010, Tiklová et al., 2010, Wang and Ward, 2010, Wang et al., 2010, Chung et al., 2009, Laprise et al., 2009, Sasikumar and Roy, 2009, Swanson et al., 2009, Warner and Longmore, 2009, Warner and Longmore, 2009, Yan et al., 2009, Zhang and Ward, 2009, Bogdanik et al., 2008, Jayaram et al., 2008, Kapelnikov et al., 2008, Laval et al., 2008, Narasimha et al., 2008, Araujo et al., 2007, Kohsaka et al., 2007, Bayraktar et al., 2006, Laprise et al., 2006, Lim and Tomlinson, 2006, Maitra et al., 2006, Ng et al., 2006, Phillips and Thomas, 2006, Schulte et al., 2006, Chen et al., 2005, Classen et al., 2005, Daneman and Barres, 2005, Williams et al., 2005, Zeitler et al., 2004, Rogers et al., 2003, Takizawa et al., 2003)

D4.1-Coracle

(Baumgartner et al., 1996)

coracle

(Jones et al., 2025, Hudson et al., 2023, Chen and St Johnston, 2022, Ahmed et al., 2020, Kiragasi et al., 2020, Lim et al., 2019, Zamudio-Arroyo and Riesgo-Escovar, 2016, Siegenthaler et al., 2015, Chung and Andrew, 2014, Gardiol and St Johnston, 2014, Lim et al., 2014, Rudrapatna et al., 2014, Eddison et al., 2012, Irion, 2012, Jaspers et al., 2012, Paré et al., 2012, Reid et al., 2012, Cammarato et al., 2011, Tjota et al., 2011, Hughes et al., 2010, Kim et al., 2010, Laprise et al., 2010, Schnorrer et al., 2010, Stork et al., 2009, Wagner et al., 2009, Hoopfer et al., 2008, Stork et al., 2008, Yi et al., 2008, Gorfinkiel and Arias, 2007, Mitonaka et al., 2007, Paul et al., 2007, Lehmann et al., 2006, Barmina et al., 2005, Lamb and Fehon, 1997, Fehon, 1994.3.29, Fehon, 1994.3.29, Fehon, 1994.3.29)

Secondary FlyBase IDs

FBgn0005646
FBgn0022032

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 75 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37205

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V8R9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V8R9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V8R9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010434

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37205/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010434

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010434

FlyMine - An integrated database for Drosophila genomics

FBgn0010434

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11949

MARRVEL_MODEL - MARRVEL (model organism gene)

37205

Linkouts

BioGRID - A database of protein and genetic interactions.

62870

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010434

DroID - A comprehensive database of gene and protein interactions.

FBgn0010434

DRSC - Results frm RNAi screens

FBgn0010434

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cora_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010434

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010434

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11949

Flygut - An atlas of the Drosophila adult midgut

FBgn0010434

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010434

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008668

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

37205

MIST (protein-protein) - An integrated Molecular Interaction Database

37205

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

References (427)