FlyBase Allele Report: Dmel\cora[5]

General Information

Symbol

Dmel\cora⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0089377

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

Also Known As

cor⁵, coracle⁵

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Bauer et al., 2004)

loss of function allele

(Ward et al., 1998)

Mutagen

ethyl methanesulfonate

(Lamb et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo | dorsal closure stage

(Ward et al., 2001)

embryonic/first instar larval cuticle

(Ward et al., 2001, Lamb et al., 1998)

embryonic/first instar larval cuticle | dorsal

(Lamb et al., 1998, Ward et al., 1998)

embryonic/larval salivary gland | embryonic stage

(Lamb et al., 1998, Ward et al., 1998)

embryonic ganglionic branch & embryonic tracheole (with cora⁴)

(Paul et al., 2003)

pleated septate junction

(Ward et al., 2001, Lamb et al., 1998)

presumptive embryonic/larval tracheal system

(Llimargas et al., 2004, Ward et al., 2001)

presumptive embryonic salivary gland

(Ward et al., 2001)

septate junction

(Genova and Fehon, 2003)

septate junction | embryonic stage

(Bauer et al., 2004)

tracheal dorsal trunk primordium (with cora⁴)

(Paul et al., 2003)

ventral denticle belt

(Lamb et al., 1998)

wing hair (with cora¹⁵)

(Venema et al., 2004)

Detailed Description

Statement

Reference

Homozygous cora⁵ mutants and cora^k08713/cora⁵ transheterozygotes show electrophysiologically detectable loss of glutamate receptors.

(Chen et al., 2005)

The septate junctions of cora⁵ mutant stage 15 embryos are disrupted.

(Bauer et al., 2004)

The tracheal systems of lates stage cora⁵ homozygous embryos have overgrown tubes with unusual expansions, defects in the accumulation of lumen antigens and lumen breaks.

(Llimargas et al., 2004)

cora⁵/cora¹⁵ mutant wings exhibit a wing hair chevron phenotype and matches of non-parallel alignment.

(Venema et al., 2004)

In cora⁵ homozygous mutants the adherens junction remains intact, with the regular spacing of plasma membranes maintained. However, the septae normally located between these membranes are reduced in number or absent. cora⁵/cora⁵ somatic clones generated in larvae (approx. 72 hours after egg laying) do not survive in adult tissues.

(Genova and Fehon, 2003)

In cora⁵/cora⁴ embryos, tracheal phenotypes are apparent from stage 15. At stage 16 in these embryos the average dorsal trunk length is significantly greater than wild type (P<0.005) (122+/-2% mean+/-s.e.m., n>5, normalized to stage 16 wild-type value). In addition these embryos have moderately severe diameter increases in the dorsal trunk and other primary tracheal branches, and some ganglionic branches exhibit missing lumen. Diameter increases are also seen in the primary tracheal branches of cora⁵ homozygous embryos. Unlike wild-type, post stage 15 trachea in cora⁵ homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.

(Paul et al., 2003)

Homozygous embryos have a dorsal open phenotype, cuticular thinning, necrosis of the salivary glands and a tracheal inflation defect. Embryos lack the individual septae that normally characterise the pleated septate junction. The salivary gland epithelium shows permeability to rhodamine-dextran, in contrast to wild type.

(Ward et al., 2001)

Homozygous embryos have a faint cuticle and a dorsal hole. The remains of the salivary glands are present as necrotic material. The epicuticle fails to adhere to the procuticle. The pleated septae that normally characterise the pleated septate junction are absent in mutant epithelia, and the transepithelial barrier function of the septate junction is also disrupted. The adherens junction appears unaffected in mutant embryos. No adult escapers are produced. Hemizygous embryos have a dorsal hole and detached cuticle. The denticle belts contain fewer denticles than normal, although the overall pattern of the denticle belts is normal.

(Lamb et al., 1998)

Homozygous embryos have dorsal closure defects; dorsal holes are seen in the cuticle. Necrosis is seen in the salivary glands.

(Ward et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cora⁵ is a suppressor of visible | dominant phenotype of Egfr^E1

(Lamb et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

cora⁵ has presumptive embryonic/larval tracheal system phenotype, non-enhanceable by nrv2^nwu3/nrv2^nwu3

(Paul et al., 2003)

NOT suppressed by

Statement

Reference

cora⁵ has presumptive embryonic/larval tracheal system phenotype, non-suppressible by nrv2^nwu3/nrv2^nwu3

(Paul et al., 2003)

NOT Enhancer of

Statement

Reference

cora⁵/cora⁵ is a non-enhancer of presumptive embryonic/larval tracheal system phenotype of nrv2^nwu3

(Paul et al., 2003)

Suppressor of

Statement

Reference

cora⁵ is a suppressor of eye phenotype of Egfr^E1

(Lamb et al., 1998)

NOT Suppressor of

Statement

Reference

cora⁵/cora⁵ is a non-suppressor of presumptive embryonic/larval tracheal system phenotype of nrv2^nwu3

(Paul et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

nrv2^nwu3; cora⁵ double mutant embryos have the same phenotype as either single mutant.

(Paul et al., 2003)

Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is smaller than wild type with some roughening.

(Lamb et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cora²

(Lamb et al., 1998)

cora¹

(Lamb et al., 1998)

Rescued by

cora⁵ is rescued by cora^3.Ubi-p63E

(Ward et al., 2001)

cora⁵ is rescued by cora^{fl.hs.Tag:MYC}

(Ward et al., 2001)

cora⁵ is rescued by cora^2.Ubi-p63E

(Ward et al., 2001)

cora⁵ is rescued by cora^1.Ubi-p63E

(Ward et al., 2001)

cora⁵ is rescued by cora^1.Ubi-p63E

(Lamb et al., 1998)

Partially rescued by

cora⁵ is partially rescued by cora^{1-383.hs.Tag:MYC}

(Ward et al., 2001)

Not rescued by

cora⁵ is not rescued by cora^{378-1698.hs.Tag:MYC}

(Ward et al., 2001)

cora⁵ is not rescued by cora^{1-1698.UAS.Tag:MYC}/Scer\GAL4^T80

(Ward et al., 2001)

cora⁵ is not rescued by cora^{1-383.UAS.Tag:MYC}/Scer\GAL4^T80

(Ward et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

52233

w^*; P{neoFRT}43D cora⁵/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

cor⁵

(Nelson et al., 2010, Wu et al., 2007, Wu et al., 2004, Behr et al., 2003, Genova and Fehon, 2003, Ward et al., 2001, Lamb et al., 1998, Ward et al., 1998)

cora5

(Khadilkar et al., 2017)

cora⁵

(Luedke et al., 2024, Lu et al., 2021, Kiragasi et al., 2020, Izumi et al., 2012, Stork et al., 2009, Chen et al., 2005)

coracle⁵

(Lim et al., 2019, Stork et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (21)

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