FlyBase Allele Report: Dmel\cora[2]

General Information

Symbol

Dmel\cora²

Species

D. melanogaster

Name

FlyBase ID

FBal0001767

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

Also Known As

cor²

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Fehon et al., 1994)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(Fehon et al., 1994)

Amino acid replacement: R544term.

(Fehon et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:19,238,975..19,238,975 [+]

Nucleotide change:

C19238975T

Reported nucleotide change:

C?T

Amino acid change:

R544term | cora-PA; R554term | cora-PF; R544term | cora-PG

Reported amino acid change:

R544term

(Fehon et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Zamudio-Arroyo and Riesgo-Escovar, 2016, Lamb et al., 1998, Fehon et al., 1994)

some die during embryonic stage | recessive

(Lamb et al., 1998, Fehon et al., 1994)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Lamb et al., 1998)

embryonic/first instar larval cuticle | dorsal

(Lamb et al., 1998)

embryonic/larval cuticle | embryonic stage

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

embryonic/larval salivary gland | embryonic stage

(Lamb et al., 1998)

embryonic dorsal epidermis

(Fehon et al., 1994)

embryonic head

(Fehon et al., 1994)

eye

(Lamb et al., 1998)

eye equator

(Lamb et al., 1998)

Detailed Description

Statement

Reference

cora² mutants die as embryos and frequently display cuticular phenotypes such as dorsal openings.

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

cora² homozygous mutants have an effective diffusion paracellular barrier in the embryonic salivary glands.

(Genova and Fehon, 2003)

Homozygous embryos have a faint cuticle and a dorsal hole. No adult escapers are produced. Hemizygous embryos show delamination of the cuticle at the anterior end of the embryo. The remains of the salivary glands are present as necrotic material. cora²/cora¹⁵ adults have eyes which show roughening across the equator.

(Lamb et al., 1998)

Failure of dorsal closure, leaving a large dorsal opening, and incomplete head involution.

(Fehon et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cora² is a suppressor of visible | dominant phenotype of Egfr^E1

(Lamb et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

cora² has embryonic/larval cuticle | embryonic stage phenotype, enhanceable by chem¹/chem[+]

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

cora² has embryonic/larval cuticle | embryonic stage phenotype, enhanceable by chem¹/chem¹

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

Enhancer of

Statement

Reference

cora[+]/cora² is an enhancer of embryonic/larval cuticle | embryonic stage phenotype of chem¹

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

cora²/cora² is an enhancer of embryonic/larval cuticle | embryonic stage phenotype of chem¹

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

Suppressor of

Statement

Reference

cora² is a suppressor of eye phenotype of Egfr^E1

(Lamb et al., 1998, Fehon et al., 1994)

Other

Statement

Reference

Atpα^unspecified, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Atpα^unspecified, cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora¹/cora², nrv2[+]/nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴/Nrx-IV[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴, cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Atpα^unspecified/Atpalpha[+], cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴/Nrx-IV[+], cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora², nrv2[+]/nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora¹/cora², nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora², nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Atpα^unspecified/Atpalpha[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency and severity of cuticular defects observed in both cora² and chem¹ homozygous embryos are significantly increased by combination with a single copy of either chem¹ or cora², respectively, as well as in cora²;chem¹ double homozygotes compared to the single homozygotes.

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

cora¹/cora² or cora²/cora² mutant embryos have an effective diffusion barrier in the embryonic salivary glands that is disrupted when Nrx-IV¹⁴/+, nrv2^unspecified/+ or Atpα^unspecified/+ is present.

(Genova and Fehon, 2003)

Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is wild type in size with some roughening.

(Lamb et al., 1998)

Completely suppresses Egfr^E1 eye phenotype.

(Fehon et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

cora¹⁴

(Lamb et al., 1998)

cora⁷

(Lamb et al., 1998)

cora⁸

(Lamb et al., 1998)

cora⁹

(Lamb et al., 1998)

cora¹⁰

(Lamb et al., 1998)

Fails to complement

cora¹¹

(Lamb et al., 1998)

cora¹²

(Lamb et al., 1998)

cora¹³

(Lamb et al., 1998)

cora¹⁵

(Lamb et al., 1998)

cora³

(Lamb et al., 1998)

cora⁵

(Lamb et al., 1998)

cora⁶

(Lamb et al., 1998)

cora⁴

(Lamb et al., 1998)

Rescued by

cora² is rescued by cora^1.Ubi-p63E

(Lamb et al., 1998)

cora² is rescued by cora^1.Ubi-p63E

(Fehon et al., 1994)

Comments

Lethality rescued by cora^1.Ubi-p63E.

(Fehon et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58805

y¹ w^*; P{y.FRT.GAL4}52B cora²/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

L27467

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB59187

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

cor²

(Genova and Fehon, 2003, Lamb et al., 1998, Ward et al., 1998)

cora2

(Khadilkar et al., 2017)

cora²

coracle²

(Zamudio-Arroyo and Riesgo-Escovar, 2016)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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