FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrx-IV14
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General Information
Symbol
Dmel\Nrx-IV14
Species
D. melanogaster
Name
FlyBase ID
FBal0058473
Feature type
allele
Associated gene
Dmel\Nrx-IV
Associated Insertion(s)
Carried in Construct
Also Known As
Nrx14
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Baumgartner et al., 1996)
Mutagen
ethyl methanesulfonate
(Baumgartner et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike wild-type, post stage 15 trachea in Nrx-IV14 homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.

      (Paul et al., 2003)

      Transheterozygotes with Df(3L)vin8 or Df(3L)BK9 are lethal, rare adults escapers are occasionally obtained. Transheterozygotes with Nrx-IV319, Nrx-IV575, Nrx-IV711 and Nrx-IV2511 allow rare adult escapers, adults exhibit rough eyes, notched wings, broadened veins and duplication and malformations of the legs.

      (Baumgartner et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Nrx-IV14, cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

      (Genova and Fehon, 2003)

      Nrx-IV14, cora2 has embryonic salivary gland & epithelial cell phenotype

      (Genova and Fehon, 2003)

      Nrx-IV14/Nrx-IV[+], cora2 has embryonic salivary gland & epithelial cell phenotype

      (Genova and Fehon, 2003)

      Nrx-IV14/Nrx-IV[+], cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

      (Genova and Fehon, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cora1/cora2 or cora2/cora2 mutant embryos have an effective diffusion barrier in the embryonic salivary glands that is disrupted when Nrx-IV14/+ is present.

      (Genova and Fehon, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nrx-IV14
      Nrx14
      (Genova and Fehon, 2003, Paul et al., 2003, Baumgartner et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)