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General Information
Symbol
Dmel\cora4
Species
D. melanogaster
Name
FlyBase ID
FBal0045477
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cor4
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

In-frame deletion of amino acids I68 to T146.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

In frame deletion of amino acids 68 to 146 in the conserved amino-terminal region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In cora5/cora4 embryos, tracheal phenotypes are apparent from stage 15. At stage 16 in these embryos the average dorsal trunk length is significantly greater than wild type (P<0.005) (122+/-2% mean+/-s.e.m., n>5, normalized to stage 16 wild-type value). In addition these embryos have moderately severe diameter increases in the dorsal trunk and other primary tracheal branches, and some ganglionic branches exhibit missing lumen.

Homozygous clones survive poorly in the wing imaginal epithelium.

Homozygous embryos have a faint cuticle and a dorsal hole. The remains of the salivary glands are present as necrotic material. No adult escapers are produced. Homozygous clones are seen in third instar wing imaginal discs. The cells within the clone are contiguous with the rest of the imaginal epithelium and appear normally shaped. cora4/cora15 adults lack the ocelli and all associated bristles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

cora4 is a suppressor of visible | dominant phenotype of EgfrE1

Phenotype Manifest In
Suppressor of
Statement
Reference

cora4 is a suppressor of eye phenotype of EgfrE1

Additional Comments
Genetic Interactions
Statement
Reference

Dominantly suppresses the rough eye phenotype of EgfrE1/+ heterozygotes; the eye is smaller than wild type with some roughening.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)