FlyBase Allele Report: Dmel\cora[4]

General Information

Symbol

Dmel\cora⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0045477

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

Also Known As

cor⁴

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Ward and Fehon, 1996)

Mutagen

ethyl methanesulfonate

(Lamb et al., 1998)

Progenitor genotype

Cytology

Description

In frame deletion of amino acids 68 to 146 in the conserved amino-terminal region.

(Ward et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:19,235,817..19,236,053 [+]

Comment:

In-frame deletion of amino acids I68 to T146.

(Ward et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | partially | recessive | somatic clone

(Ward et al., 2001)

lethal | recessive

(Ward et al., 2001)

lethal - all die during embryonic stage | recessive

(Lamb et al., 1998)

some die during embryonic stage | recessive

(Lamb et al., 1998)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Lamb et al., 1998)

embryonic/first instar larval cuticle | dorsal

(Lamb et al., 1998)

embryonic/larval salivary gland | embryonic stage

(Lamb et al., 1998)

embryonic ganglionic branch & embryonic tracheole (with cora⁵)

(Paul et al., 2003)

interocellar bristle

(Lamb et al., 1998)

ocellar bristle

(Lamb et al., 1998)

ocellus

(Lamb et al., 1998)

tracheal dorsal trunk primordium (with cora⁵)

(Paul et al., 2003)

Detailed Description

Statement

Reference

In cora⁵/cora⁴ embryos, tracheal phenotypes are apparent from stage 15. At stage 16 in these embryos the average dorsal trunk length is significantly greater than wild type (P<0.005) (122+/-2% mean+/-s.e.m., n>5, normalized to stage 16 wild-type value). In addition these embryos have moderately severe diameter increases in the dorsal trunk and other primary tracheal branches, and some ganglionic branches exhibit missing lumen.

(Paul et al., 2003)

Homozygous clones survive poorly in the wing imaginal epithelium.

(Ward et al., 2001)

Homozygous embryos have a faint cuticle and a dorsal hole. The remains of the salivary glands are present as necrotic material. No adult escapers are produced. Homozygous clones are seen in third instar wing imaginal discs. The cells within the clone are contiguous with the rest of the imaginal epithelium and appear normally shaped. cora⁴/cora¹⁵ adults lack the ocelli and all associated bristles.

(Lamb et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cora⁴ is a suppressor of visible | dominant phenotype of Egfr^E1

(Lamb et al., 1998)

Phenotype Manifest In