FlyBase Allele Report: Dmel\cora[GD1405]

General Information

Symbol

Dmel\cora^GD1405

Species

D. melanogaster

Name

FlyBase ID

FBal0209277

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

P{GD1405}

Also Known As

cora^RNAi, UAS-coracle-RNAi, UAS-cora RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1405}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1405

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of inflammatory bowel disease

CEA

(Bonnay et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

external sensory organ precursor cell | P-stage, with Scer\GAL4^pnr.PU

(Bruelle et al., 2023)

indirect flight muscle cell, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

midbody | P-stage, with Scer\GAL4^pnr.PU

(Bruelle et al., 2023)

myofibril, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

sarcomere, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

smooth septate junction, with Scer\GAL4^NP3084

(Bonnay et al., 2013)

Detailed Description

Statement

Reference

The paracellular space at the level of the smooth septate junction shows a gap of 30nm between the two plasma membranes in the midgut of adults expressing cora^GD1405 under the control of Scer\GAL4^NP3084 (in contrast to the 20nm space seen in wild type).

Flies expressing cora^GD1405 under the control of Scer\GAL4^NP3084 die faster than wild-type flies after oral infection with Pseudomonas aeruginosa PA14.

(Bonnay et al., 2013)

Adults expressing cora^GD1405 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in missing adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in degenerate myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in missing sarcomeres in the adult indirect flight muscles.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development