FB2026_02 , released June 18, 2026
Gene: Dmel\yrt
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General Information
Symbol
Dmel\yrt
Species
D. melanogaster
Name
yurt
Annotation Symbol
CG9764
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004049
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
yurt (yrt) encodes a membrane-associated protein. It contributes to apical-basal polarity and permeability of septate junctions. In differentiating epithelial cells, it counteracts apical polarity proteins to sustain lateral membrane stability and apical-basal polarity. In fully differentiated cells, the product of yrt acts as a negative regulatory component of the crb complex and limits apical membrane growth. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)m112, m112, l(3)87Ek

Key Links
Genomic Location
Cytogenetic map
87E11-87E11
Sequence location
Recombination map
3-53
RefSeq locus
NT_033777 REGION:13428867..13434984
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cytoskeletal protein binding
inferred from electronic annotation with InterPro:IPR000798
(InterPro Project Members, 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in amnioserosa maintenance
inferred from mutant phenotype
(Hoover and Bryant, 2002)
involved_in dorsal closure
inferred from mutant phenotype
(Hoover and Bryant, 2002)
involved_in establishment of epithelial cell apical/basal polarity
inferred from genetic interaction with FLYBASE:aPKC; FB:FBgn0261854
(Gamblin et al., 2014)
involved_in establishment or maintenance of apical/basal cell polarity
inferred from mutant phenotype
(Laprise et al., 2006)
involved_in eye photoreceptor cell development
inferred from mutant phenotype
(Laprise et al., 2006)
involved_in germ-band shortening
inferred from mutant phenotype
(Hoover and Bryant, 2002)
involved_in head involution
inferred from mutant phenotype
(Hoover and Bryant, 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in actomyosin structure organization
inferred from biological aspect of ancestor with PANTHER:PTN008596437
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Laprise et al., 2006)
located_in nuclear envelope
inferred from direct assay
(Gamblin et al., 2018)
located_in septate junction
inferred from direct assay
(Laprise et al., 2006)
located_in zonula adherens
inferred from direct assay
(Laprise et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN008596437
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
yurt (yrt) encodes a membrane-associated protein. It contributes to apical-basal polarity and permeability of septate junctions. In differentiating epithelial cells, it counteracts apical polarity proteins to sustain lateral membrane stability and apical-basal polarity. In fully differentiated cells, the product of yrt acts as a negative regulatory component of the crb complex and limits apical membrane growth. [Date last reviewed: 2019-03-21]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
yrt: yurt
Embryonic lethal mutation. Embryos show a dorsal posterior hole.
Summary (Interactive Fly)

ERM junctional protein involved in regulating apical-basal polarity - tracheal development

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\yrt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VFU8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.54

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
yrt-RA
FBtr0082793
NM_142034
4369
972
yrt-RB
FBtr0114374
NM_001144572
4249
932
yrt-RC
FBtr0114375
NM_001144573
3811
786
yrt-RD
FBtr0114376
NM_001144574
4464
919
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
yrt-PA
FBpp0082261
105.2
972
8.25
Q9VFU8
NP_650291
AAF54951
yrt-PB
FBpp0112923
101.0
932
8.50
A0T1Z4
NP_001138044
ACL83502
yrt-PC
FBpp0112924
86.5
786
9.04
A0T1Z5
NP_001138045
ACL83503
yrt-PD
FBpp0112925
99.5
919
7.79
B7Z0J2
NP_001138046
ACL83504
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yrt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.48

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14
larval tracheal system
(Laprise et al., 2010)
Additional Descriptive Data

yrt is is enriched in the upper region of the lateral membrane of tracheal cells and colocalizes with an Nrx-IV septate junction marker.

(Laprise et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Laprise et al., 2006)
located_in nuclear envelope
inferred from direct assay
(Gamblin et al., 2018)
located_in septate junction
inferred from direct assay
(Laprise et al., 2006)
located_in zonula adherens
inferred from direct assay
(Laprise et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\yrt in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of yrt
Transgenic constructs containing regulatory region of yrt
Aberrations (Deficiencies and Duplications) ( 30 )
Inferred from experimentation ( 30 )
Gene disrupted in
Df(3R)2515
(McCarron et al., 1994)
Df(3R)2520
(McCarron et al., 1994)
Df(3R)Exel7320
(Ryder, 2004.4.26)
Df(3R)l26c
(Hoover and Bryant, 2002, Manseau et al., 1988, Tearle and Nusslein-Volhard, 1987, Jurgens et al., 1984, Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry506-85C
(Harbecke and Lengyel, 1995)
Df(3R)ry619
(Manseau et al., 1988, Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Gene not disrupted in
Df(3R)615
(McCarron et al., 1994)
Df(3R)2519
(McCarron et al., 1994)
Df(3R)2521
(McCarron et al., 1994)
Df(3R)2522
(McCarron et al., 1994)
Df(3R)2523
(McCarron et al., 1994)
Df(3R)2524
(McCarron et al., 1994)
Df(3R)2525
(McCarron et al., 1994)
Df(3R)2526
(McCarron et al., 1994)
Df(3R)2527
(McCarron et al., 1994)
Df(3R)2528
(McCarron et al., 1994)
Df(3R)kar-H5
(McCarron et al., 1994)
Df(3R)kar-lG27
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)kar-Sz8
(Tearle and Nusslein-Volhard, 1987)
Df(3R)kar-Sz11
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)l26d
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)lC4a
(Manseau et al., 1988, Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry36
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry75
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry614
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry1168
(Manseau et al., 1988, Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry1301
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry1402
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry1607
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Df(3R)ry1608
(Rushlow and Chovnick, 1984, Hilliker et al., 1981, Hilliker et al., 1980)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4da.G32
lethal - all die during embryonic stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell polarity, with Scer\GAL4da.G32
abnormal cell polarity | embryonic stage
abnormal cell polarity | embryonic stage 13 | germline clone
abnormal cell polarity | embryonic stage (with yrt75)
abnormal cell polarity | embryonic stage (with yrtF281R.W283R)
flightless, with Scer\GAL4Mef2.PR
some die during embryonic stage | recessive
Phenotype manifest in
Allele
adherens junction
amnioserosa
apical plasma membrane | embryonic stage
apical plasma membrane | embryonic stage (with yrt75)
apical plasma membrane | embryonic stage (with yrtF281R.W283R)
denticle field | embryonic stage
denticle field | embryonic stage (with yrt75)
denticle field | embryonic stage (with yrtF281R.W283R)
dorsal ridge
embryo | dorsal | posterior
embryonic/first instar larval cuticle (with Df(3R)l26c)
embryonic/first instar larval cuticle (with yrt87Ek-8)
embryonic/first instar larval cuticle (with yrt87Ek-9)
embryonic/first instar larval cuticle | germline clone
embryonic/larval cuticle, with Scer\GAL4da.G32
embryonic/larval cuticle | embryonic stage
embryonic/larval cuticle | embryonic stage (with yrt75)
embryonic/larval cuticle | embryonic stage (with yrtF281R.W283R)
embryonic epidermis
embryonic epidermis (with yrt75)
embryonic epidermis (with yrtF281R.W283R)
embryonic head (with Df(3R)l26c)
embryonic head (with yrt87Ek-8)
embryonic head (with yrt87Ek-9)
embryonic head epidermis
embryonic head epidermis (with yrt75)
embryonic head epidermis (with yrtF281R.W283R)
epidermal cell | embryonic stage
epidermal cell | embryonic stage (with yrt75)
epidermal cell | embryonic stage (with yrtF281R.W283R)
epidermis | embryonic stage 13 | germline clone
eye photoreceptor cell | conditional
eye photoreceptor cell stalk
macrochaeta
myofibril, with Scer\GAL4Mef2.PR
ommatidium
photoreceptor cell R8, with Scer\GAL4GMR.long
rhabdomere of eye photoreceptor cell
tracheal section | embryonic stage 13 | germline clone
ventral denticle belt | embryonic stage
ventral denticle belt | embryonic stage (with yrt75)
ventral denticle belt | embryonic stage (with yrtF281R.W283R)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (42)
Hsap\EPB41L5
10 of 14
Yes
Yes
Hsap\EPB41L4B
9 of 14
No
Yes
Hsap\EPB41L4A
5 of 14
No
No
Hsap\EPB41
3 of 14
No
No
Hsap\EPB41L1
3 of 14
No
No
Hsap\EPB41L2
3 of 14
No
No
1  
Hsap\EPB41L3
3 of 14
No
No
Hsap\FRMD3
3 of 14
No
No
Hsap\FRMD5
3 of 14
No
No
7  
Hsap\FRMD6
3 of 14
No
No
Hsap\FARP1
2 of 14
No
No
Hsap\FARP2
2 of 14
No
No
Hsap\EZR
1 of 14
No
No
1  
Hsap\FGD2
1 of 14
No
No
Hsap\FGD3
1 of 14
No
No
Hsap\FGD4
1 of 14
No
No
Hsap\FGD6
1 of 14
No
No
Hsap\FRMD1
1 of 14
No
No
Hsap\FRMD4A
1 of 14
No
No
Hsap\FRMD4B
1 of 14
No
No
Hsap\FRMD7
1 of 14
No
No
Hsap\FRMPD2
1 of 14
No
No
Hsap\LAMB2
1 of 14
No
No
Hsap\MSN
1 of 14
No
No
Hsap\MYLIP
1 of 14
No
No
Hsap\NF2
1 of 14
No
No
10  
Hsap\PREX1
1 of 14
No
No
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN6
1 of 14
No
No
3  
Hsap\PTPN9
1 of 14
No
No
Hsap\PTPN13
1 of 14
No
No
Hsap\PTPN14
1 of 14
No
No
Hsap\PTPN20
1 of 14
No
No
Hsap\PTPN21
1 of 14
No
No
Hsap\PTPRE
1 of 14
No
No
Hsap\PTPRR
1 of 14
No
No
1  
Hsap\PTPRU
1 of 14
No
No
Hsap\RDX
1 of 14
No
No
1  
Hsap\TLN1
1 of 14
No
No
Hsap\TLN2
1 of 14
No
No
Hsap\TRIO
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (37)
Rnor\Epb41l5
9 of 14
Yes
Yes
Rnor\Epb41l4b
8 of 14
No
Yes
Rnor\Epb41l4a
5 of 14
No
No
Rnor\Epb41l3
3 of 14
No
No
Rnor\Epb41
3 of 14
No
No
Rnor\Frmd3
3 of 14
No
No
Rnor\Frmd5
3 of 14
No
No
Rnor\Epb41l1
2 of 14
No
No
Rnor\Epb41l2
2 of 14
No
No
Rnor\Farp1
2 of 14
No
No
Rnor\Farp2
2 of 14
No
No
Rnor\Frmd6
2 of 14
No
No
Rnor\LOC298139
2 of 14
No
Yes
Rnor\Arhgef3
1 of 14
No
No
Rnor\Ezr
1 of 14
No
No
Rnor\Fgd2
1 of 14
No
No
Rnor\Fgd3
1 of 14
No
No
Rnor\Fgd4
1 of 14
No
No
Rnor\Fgd6
1 of 14
No
No
Rnor\Frmd4a
1 of 14
No
Yes
Rnor\Frmd4b
1 of 14
No
No
Rnor\Frmd7
1 of 14
No
No
Rnor\Frmpd2
1 of 14
No
Yes
Rnor\Msn
1 of 14
No
No
Rnor\Mylip
1 of 14
No
No
Rnor\Nf2
1 of 14
No
No
Rnor\Ptpn3
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Ptpn6
1 of 14
No
No
Rnor\Ptpn13
1 of 14
No
No
Rnor\Ptpn14
1 of 14
No
No
Rnor\Ptpn21
1 of 14
No
No
Rnor\Ptprb
1 of 14
No
No
Rnor\Ptprf
1 of 14
No
No
Rnor\Rdx
1 of 14
No
No
Rnor\Trio
1 of 14
No
No
Rnor\Vav2
1 of 14
No
No
Mus musculus (laboratory mouse) (34)
Mmus\Epb41l4b
9 of 14
Yes
Yes
Mmus\Epb41l5
8 of 14
No
Yes
Mmus\Epb41l4a
5 of 14
No
No
Mmus\Epb41l1
3 of 14
No
No
Mmus\Epb41l2
3 of 14
No
No
Mmus\Epb41l3
3 of 14
No
No
Mmus\Frmd3
3 of 14
No
No
Mmus\Frmd5
3 of 14
No
No
Mmus\Frmd6
3 of 14
No
No
Mmus\2310002L09Rik
2 of 14
No
Yes
Mmus\Epb41
2 of 14
No
No
Mmus\Farp1
2 of 14
No
No
Mmus\Farp2
2 of 14
No
No
Mmus\Arhgef16
1 of 14
No
No
Mmus\Ezr
1 of 14
No
No
Mmus\Fgd2
1 of 14
No
No
Mmus\Fgd4
1 of 14
No
No
Mmus\Fgd6
1 of 14
No
No
Mmus\Frmd4a
1 of 14
No
No
Mmus\Frmd4b
1 of 14
No
No
Mmus\Frmd7
1 of 14
No
No
Mmus\Frmpd2
1 of 14
No
Yes
Mmus\Msn
1 of 14
No
No
Mmus\Mylip
1 of 14
No
No
Mmus\Nf2
1 of 14
No
No
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Ptpn6
1 of 14
No
No
Mmus\Ptpn13
1 of 14
No
No
Mmus\Ptpn14
1 of 14
No
No
Mmus\Ptpn21
1 of 14
No
No
Mmus\Ptprb
1 of 14
No
No
Mmus\Rdx
1 of 14
No
No
Mmus\Trio
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\epb41l4b
5 of 13
Yes
Yes
Xtro\epb41l5
5 of 13
Yes
Yes
Xtro\epb41l4a
2 of 13
No
No
Xtro\farp1
2 of 13
No
No
Xtro\gabrp
2 of 13
No
Yes
Xtro\epb41l3
1 of 13
No
No
Xtro\fgd1
1 of 13
No
No
Xtro\frmd3
1 of 13
No
No
Xtro\frmd4a
1 of 13
No
Yes
Xtro\frmd4b
1 of 13
No
Yes
Xtro\frmd6
1 of 13
No
No
Xtro\frmd7
1 of 13
No
No
Xtro\LOC101731001
1 of 13
No
No
Xtro\mylip
1 of 13
No
No
Xtro\nfia
1 of 13
No
No
Xtro\nploc4
1 of 13
No
No
Xtro\ptpn14
1 of 13
No
No
Xtro\ptpn21
1 of 13
No
No
Xtro\ptprz1
1 of 13
No
No
Xtro\spata17
1 of 13
No
No
Xtro\srrm2
1 of 13
No
No
Xtro\trio
1 of 13
No
No
Xtro\ttc13
1 of 13
No
Yes
Danio rerio (Zebrafish) (43)
Drer\epb41l5
9 of 14
Yes
Yes
Drer\epb41l4b
6 of 14
No
Yes
Drer\epb41l4a
5 of 14
No
No
Drer\epb41b
3 of 14
No
No
Drer\epb41l3a
3 of 14
No
No
Drer\frmd5b
3 of 14
No
No
Drer\frmd6
3 of 14
No
No
Drer\LOC570903
3 of 14
No
No
Drer\farp1
2 of 14
No
No
Drer\farp2
2 of 14
No
No
Drer\arhgef15a
1 of 14
No
No
Drer\arhgef25b
1 of 14
No
No
Drer\epb41a
1 of 14
No
No
Drer\epb41l3b
1 of 14
No
No
Drer\ezra
1 of 14
No
No
Drer\ezrb
1 of 14
No
No
Drer\fgd1
1 of 14
No
No
Drer\fgd4a
1 of 14
No
No
Drer\fgd4b
1 of 14
No
No
Drer\frmd3
1 of 14
No
No
Drer\frmd4a
1 of 14
No
No
Drer\frmd4ba
1 of 14
No
No
Drer\frmd4bb
1 of 14
No
No
Drer\frmd7
1 of 14
No
No
Drer\frmpd2
1 of 14
No
No
Drer\kalrna
1 of 14
No
No
Drer\kalrnb
1 of 14
No
No
Drer\LOC557811
1 of 14
No
No
Drer\msna
1 of 14
No
No
Drer\msnb
1 of 14
No
No
Drer\mylipa
1 of 14
No
No
Drer\mylipb
1 of 14
No
No
Drer\nf2a
1 of 14
No
No
Drer\nf2b
1 of 14
No
No
Drer\ptpn3
1 of 14
No
No
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\ptpn9a
1 of 14
No
No
Drer\ptpn13
1 of 14
No
Yes
Drer\ptpn21
1 of 14
No
No
Drer\si:dkey-178k16.1
1 of 14
No
No
Drer\triob
1 of 14
No
No
Drer\zgc:172136
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\frm-2
10 of 14
Yes
Yes
Cele\clr-1
1 of 14
No
No
Cele\epi-1
1 of 14
No
No
Cele\erm-1
1 of 14
No
No
Cele\exc-5
1 of 14
No
No
Cele\F07C6.4
1 of 14
No
Yes
Cele\frm-1
1 of 14
No
No
Cele\frm-3
1 of 14
No
No
Cele\frm-4
1 of 14
No
No
Cele\frm-5.1
1 of 14
No
Yes
Cele\frm-5.2
1 of 14
No
No
Cele\frm-7
1 of 14
No
No
Cele\M88.4
1 of 14
No
No
Cele\nfm-1
1 of 14
No
No
Cele\ptp-1
1 of 14
No
No
Cele\ptp-3
1 of 14
No
No
Cele\tag-77
1 of 14
No
No
Cele\tln-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (16)
Agam\AgaP_AGAP004136
11 of 12
Yes
Yes
Agam\AgaP_AGAP001632
3 of 12
No
No
Agam\AgaP_AGAP008811
3 of 12
No
No
Agam\AgaP_AGAP012185
2 of 12
No
No
Agam\AgaP_AGAP001109
1 of 12
No
No
Agam\AgaP_AGAP001287
1 of 12
No
No
Agam\AgaP_AGAP001609
1 of 12
No
No
Agam\AgaP_AGAP002725
1 of 12
No
No
Agam\AgaP_AGAP007130
1 of 12
No
No
Agam\AgaP_AGAP007474
1 of 12
No
No
Agam\AgaP_AGAP009126
1 of 12
No
No
Agam\AgaP_AGAP009180
1 of 12
No
No
Agam\AgaP_AGAP009975
1 of 12
No
No
Agam\AgaP_AGAP010346
1 of 12
No
No
Agam\AgaP_AGAP013042
1 of 12
No
No
Agam\MOEH_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G20110
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CSS1
1 of 13
Yes
Yes
Scer\HPF1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:yrt. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
Frmd5
5 of 13
cora
4 of 13
CG34347
3 of 13
dnr1
3 of 13
Cdep
1 of 13
CG12075
1 of 13
ex
1 of 13
Mer
1 of 13
Moe
1 of 13
Pez
1 of 13
Ptpmeg
1 of 13
rhea
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EPB41L5; erythrocyte membrane protein band 4.1 like 5
    10 of 14
    611730
        EPB41L4B; erythrocyte membrane protein band 4.1 like 4B
        9 of 14
        610340
            EPB41L4A; erythrocyte membrane protein band 4.1 like 4A
            5 of 14
            612141
                EPB41; erythrocyte membrane protein band 4.1
                3 of 14
                130500
                EPB41L1; erythrocyte membrane protein band 4.1 like 1
                3 of 14
                602879
                EPB41L2; erythrocyte membrane protein band 4.1 like 2
                3 of 14
                603237
                     
                    EPB41L3; erythrocyte membrane protein band 4.1 like 3
                    3 of 14
                    605331
                        FRMD3; FERM domain containing 3
                        3 of 14
                        607619
                            FRMD5; FERM domain containing 5
                            3 of 14
                            FERM DOMAIN-CONTAINING PROTEIN 5; FRMD5
                             
                            FRMD6; FERM domain containing 6
                            3 of 14
                            614555
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                Interaction Browsers
                                View in FlyBase Interactions Browser   View in MIST tool (external link)
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                yrt
                                suppressible
                                chem
                                (Zamudio-Arroyo and Riesgo-Escovar, 2016)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                chem
                                suppressible
                                yrt
                                (Zamudio-Arroyo and Riesgo-Escovar, 2016)
                                chem
                                enhanceable
                                yrt
                                (Zamudio-Arroyo and Riesgo-Escovar, 2016)
                                crb
                                suppressible
                                yrt
                                (Laprise et al., 2006)
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                FlyBase
                                External Links
                                External Data
                                Linkouts
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                Class of Gene
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3R
                                Recombination map
                                3-53
                                Cytogenetic map
                                87E11-87E11
                                Sequence location
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                87E11-87E11
                                Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                Experimentally Determined Recombination Data
                                Location

                                3-53

                                (FlyBase, 2016)

                                3-50.9

                                (Comeron et al., 2012)

                                3-52

                                (Tearle and Nusslein-Volhard, 1987)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (20)
                                Genomic Clones (18)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (76)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                Antibody Information
                                Laboratory Generated Antibodies
                                 

                                polyclonal

                                (Laprise et al., 2006)
                                Commercially Available Antibodies
                                 
                                Cell Line Information
                                Publicly Available Cell Lines
                                 
                                  Other Stable Cell Lines
                                   
                                    Other Comments

                                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                    (Kiger et al., 2003)

                                    Homozygous mutant embryos show a failure in germ-band retraction, dorsal closure and head involution, associated with degeneration of the amnioserosa.

                                    (Hoover and Bryant, 2002)

                                    Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

                                    (Claridge-Chang et al., 2001)

                                    Required for dorsal closure and the completion of terminal development.

                                    (Hoover and Bryant, 2000)

                                    yrt mutants display failure of posterior dorsal closure.

                                    (Jurgens et al., 1984)
                                    Relationship to Other Genes
                                    Source for database merge of

                                    Source for merge of: yrt l(3)87Ek

                                    (Hoover and Bryant, 2002)
                                    Additional comments

                                    Three complementation groups.

                                    Nomenclature History
                                    Source for database identify of
                                    Nomenclature comments
                                    Etymology
                                    Synonyms and Secondary IDs (13)
                                    Reported As
                                    Symbol Synonym
                                    CG9764
                                    (Rosa-Ferreira et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Molnar et al., 2006, Giot et al., 2003, Claridge-Chang et al., 2001, Goldstein and Gunawardena, 2000)
                                    Nbl4
                                    (Hoover and Bryant, 2000)
                                    Yrt
                                    (Lee et al., 2020, Flores-Benitez and Knust, 2016, Gamblin et al., 2014, Genevet and Tapon, 2011, Laprise et al., 2009, Laprise et al., 2008)
                                    Yurt
                                    (Buckley and St Johnston, 2022, Salis et al., 2017, Laprise and Tepass, 2011)
                                    dlhB
                                    l(3)87Ek
                                    (McCarron et al., 1994)
                                    l(3)E19
                                    l(3)m112
                                    (Hoover and Bryant, 2002, Hilliker et al., 1980, Hall and Kankel, 1976)
                                    m112
                                    (Manseau et al., 1988, Rushlow and Chovnick, 1984, Hilliker et al., 1981)
                                    yrt
                                    (Biehler et al., 2021, Rice et al., 2021, Rouka et al., 2021, Gamblin et al., 2018, Sarov et al., 2016, Flores-Benitez and Knust, 2015, Ashwal-Fluss et al., 2014, Sun et al., 2012, Laprise et al., 2010, Nelson et al., 2010, Bakal et al., 2007, Molnar et al., 2006)
                                    yurt
                                    (Salis et al., 2017)
                                    Name Synonyms
                                    Yurt
                                    (Finegan and Bergstralh, 2020, Skouloudaki et al., 2019, Saito et al., 2018, Stephens et al., 2018, Gamblin et al., 2014, Chen and Zhang, 2013, Tepass, 2012, Rodrigues et al., 2011, Laprise et al., 2009, Laprise et al., 2008)
                                    dorsal holes B
                                    lethal(3)87Ek
                                    yurt
                                    (Dong et al., 2025, McSharry and Beitel, 2019, Wieschaus and Nüsslein-Volhard, 2016, Zamudio-Arroyo and Riesgo-Escovar, 2016, Chen et al., 2010, Laprise et al., 2010, Laprise et al., 2006)
                                    Secondary FlyBase IDs
                                    • FBgn0000466
                                    • FBgn0002363
                                    • FBgn0038155
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    External Crossreferences and Linkouts ( 66 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    FlyMine - An integrated database for Drosophila genomics
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    References (94)