FB2026_02 , released June 18, 2026
Allele: Dmel\yrt3
Open Close
General Information
Symbol
Dmel\yrt3
Species
D. melanogaster
Name
FlyBase ID
FBal0018820
Feature type
allele
Associated gene
Dmel\yrt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      yrt3 homozygotes die as embryos and display dorsal closure defects.

      (Zamudio-Arroyo and Riesgo-Escovar, 2016)

      weak allele

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The embryonic cuticular phenotype (dorsal closure defects) and lethality of yrt3 homozygous mutants is significantly suppressed by combination with either chem1 or chem3 in heterozygous state and some of the animals progress to larval stage. Over half of yrt3/yrt3;chem1/+ larvae (when cultures separately) manage to pupariate. Conversely, the embryonic phenotypes of chem1 or chem3 homozygotes are slightly but significantly improved by combination with a single copy of yrt3. The cuticular phenotype of either yrt3;chem1 or yrt3;chem3 double homozygous embryos is improved relative to yrt3 single mutants but worsened relative to either chem1 or chem3 homozygotes.

      (Zamudio-Arroyo and Riesgo-Escovar, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      yrt10H
      (Tearle and Nusslein-Volhard, 1987)
      yrt3
      yurt3
      (Zamudio-Arroyo and Riesgo-Escovar, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)