chem³ homozygotes (as well as chem¹/chem³) are embryonic/larval lethal, the animals that die as embryos show severe cuticular defects (including no cuticle, dorsal open or head involution defective phenotypes) and disruption of the lateral epithelium architecture, chem³ mutant epithelial cells are also significantly longer compared to wild-type.

When cultured separately from their balancer-containing heterozygous siblings some of the surviving homozygous larvae manage to pupariate and yield adults, these however die shortly after eclosion.

Embryos both maternally and zygotically mutant for chem³ (coming from mothers with chem³ germline clones generated by the OvoD method) display severe cuticular defects - stronger than in zygotic only mutants - with majority forming no cuticle at all, heteroallelic embryos coming from chem¹ mutant mothers and chem³ fathers or from chem³ mothers and chem⁵ fathers show similarly severe cuticular defects. These embryonic phenotypes are significantly improved by paternal rescue.

chem³/chem[+] is a suppressor | partially of lethal - all die during embryonic stage | recessive phenotype of yrt³

chem³ has embryonic/larval cuticle | embryonic stage phenotype, enhanceable by yrt³/yrt³

chem³ has embryonic/larval cuticle | embryonic stage phenotype, suppressible | partially by yrt[+]/yrt³