FlyBase Allele Report: Hsap\HTT[128Q.1-231.UAS]

General Information

Symbol

Hsap\HTT^{128Q.1-231.UAS}

Species

H. sapiens

Name

FlyBase ID

FBal0368452

Feature type

allele

Associated gene

Hsap\HTT

Associated Insertion(s)

Carried in Construct

P{UAS-HTT.128Q.1-231}

Also Known As

UAS-HTT^NT231Q128

Key Links

Transgenic product class

inframe_deletion

(Onur et al., 2021)

trinucleotide_repeat_expansion

(Onur et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Onur et al., 2021)

trinucleotide_repeat_expansion

(Onur et al., 2021)

Mutagen

in vitro construct

(Onur et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-HTT.128Q.1-231}

Cytology

Description

UAS drives expression of the N-terminal amino acids 1-231 of Hsap\HTT protein with a pathogenic polyQ tract of 128 amino acids.

(Onur et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\HTT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Huntington's disease

CEA

(Hernandez et al., 2023, Reyes-Ortiz et al., 2023, Greco et al., 2022, Onur et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Huntington's disease

is ameliorated by NfI^JF02219

(Reyes-Ortiz et al., 2023)

is ameliorated by NfI^MI06280

(Reyes-Ortiz et al., 2023)

is ameliorated by Abl^UAS.cFa

(Onur et al., 2021)

is ameliorated by AnxB10^d03410

(Onur et al., 2021)

is ameliorated by CG43373^KK110535

(Onur et al., 2021)

is ameliorated by CG8916^GD3383

(Onur et al., 2021)

is ameliorated by CenG1A^MI06024

(Onur et al., 2021)

is exacerbated by Jra^NIG.2275R

(Onur et al., 2021)

is ameliorated by Nrx-1^MI02579

(Onur et al., 2021)

is exacerbated by Pkc53E^GD11984

(Onur et al., 2021)

is ameliorated by PlexA^NIG.11081R

(Onur et al., 2021)

is ameliorated by Pvr^GD75

(Onur et al., 2021)

is ameliorated by RhoBTB^VSH330130

(Onur et al., 2021)

is exacerbated by SH3PX1^NIG.6757R

(Onur et al., 2021)

is exacerbated by Snap25^NIG.17676R

(Onur et al., 2021)

is exacerbated by Spn42De^KK103216

(Onur et al., 2021)

is ameliorated by Sytβ^KK112599

(Onur et al., 2021)

is ameliorated by cora¹⁴

(Onur et al., 2021)

is ameliorated by dpn^GFP.FPTB

(Onur et al., 2021)

is ameliorated by ena^{UASp.B.mCherry}

(Onur et al., 2021)

is ameliorated by mGluR^NIG.11144R

(Onur et al., 2021)

is exacerbated by mahe^GD17235

(Onur et al., 2021)

is ameliorated by nmdyn-D7^GD13902

(Onur et al., 2021)

is ameliorated by sif^NIG.5406R

(Onur et al., 2021)

is ameliorated by trn^S064117

(Onur et al., 2021)

is exacerbated by tsr^N121

(Onur et al., 2021)

is ameliorated by vlc^k01109

(Onur et al., 2021)

is ameliorated by zld^GFP.FPTB

(Onur et al., 2021)

is ameliorated by Itgbn^HM05089

(Hernandez et al., 2023)

is ameliorated by Itgbn^HMJ23472

(Hernandez et al., 2023)

is ameliorated by if^HMC06096

(Hernandez et al., 2023)

is ameliorated by if^HMS01872

(Hernandez et al., 2023)

is ameliorated by if^JF02695

(Hernandez et al., 2023)

is ameliorated by if^MI12214

(Hernandez et al., 2023)

is ameliorated by if^WKO.P1-D4

(Hernandez et al., 2023)

is ameliorated by mew^HMS02849

(Hernandez et al., 2023)

is ameliorated by mew^JF02694

(Hernandez et al., 2023)

is ameliorated by mew^TKO.GS00808

(Hernandez et al., 2023)

is ameliorated by mys^HMS00043

(Hernandez et al., 2023)

is ameliorated by mys^JF02819

(Hernandez et al., 2023)

is ameliorated by scb^HMS01873

(Hernandez et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by if^HMS01872, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by if^HMC06096, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by scb^HMS01873, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by ItgaPS4^HMC02928, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by mys^UAS.cLa, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, non-enhanceable by mys^UAS.cLa, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by Itgbn^HM05089, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by Itgbn^HMJ23472, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Suppressed by

Statement

Reference

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by if^MI12214

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by mew^JF02694, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible by mew^JF02694, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by mew^HMS02849, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by mew^HMS02849, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by if^JF02695, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by if^JF02695, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by if^HMS01872, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by if^HMC06096, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by scb^JF02696, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible by scb^JF02696, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by scb^HMS01873, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by ItgaPS4^HM05021, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by ItgaPS4^HM05021, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by ItgaPS4^HMC02928, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible by mys^JF02819, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by mys^HMS00043, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by Itgbn^HM05089, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, suppressible by Itgbn^HMJ23472, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has short lived phenotype, suppressible by mew^JF02694, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has short lived phenotype, suppressible by if^MI12214

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior | progressive phenotype, suppressible by NfI^MI06280

(Reyes-Ortiz et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior | progressive phenotype, suppressible by NfI^JF02219, Scer\GAL4^repo

(Reyes-Ortiz et al., 2023)

NOT suppressed by

Statement

Reference

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by if^HMS01872, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by if^HMC06096, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by scb^HMS01873, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by ItgaPS4^HMC02928, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by mys^UAS.cLa, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo has decreased rate of adult locomotory behavior phenotype, non-suppressible by mys^UAS.cLa, Scer\GAL4^repo

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by Itgbn^HM05089, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by Itgbn^HMJ23472, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HTT ^231NT-128Q

(Hernandez et al., 2023)

HTT^231NT128Q

(Hernandez et al., 2023)

Hsap\HTT^{128Q.1-231.UAS}

Name Synonyms

Secondary FlyBase IDs

References (5)

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