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General Information
Symbol
Dmel\mysJF02819
Species
D. melanogaster
Name
FlyBase ID
FBal0242397
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-mysRNAi, JF02819
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult flies expressing mysJF02819 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

Expressing mysJF02819 under the control of Scer\GAL4repo (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in decreased glial cell numbers in the eye discs of third instar larvae. Photoreceptor axon targeting to the optic stalk is unaffected.

Expression of mysGD15002 under the control of Scer\GAL4NP5130, in combination with a Gal80[ts] transgene to restrict expression to the two weeks of adulthood prior to analysis, results in a reduction in Esg-positive progenitors, including a reduction in intestinal stem cell numbers, in the adult posterior midgut, with with a decrease in cell division (PH3 staining) and no increase in apoptosis (TUNEL assay).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-Arnwy1/AdamTS-Arnwy2 mutant third instar larvae is partially suppressed by Scer\GAL4repo-driven expression of mysJF02819.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mysJF02819
Name Synonyms
Secondary FlyBase IDs
    References (13)