FlyBase Allele Report: Dmel\cora[1]

General Information

Symbol

Dmel\cora¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001766

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

Also Known As

cor¹

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Fehon et al., 1994)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(Fehon et al., 1994)

Amino acid replacement: Q529term.

(Fehon et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:19,238,930..19,238,930 [+]

Nucleotide change:

C19238930T

Reported nucleotide change:

C?T

Amino acid change:

Q529term | cora-PA; Q539term | cora-PF; Q529term | cora-PG

Reported amino acid change:

Q529term

(Ward et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

L27467

AAB59187

UniProtKB/Swiss-Prot

Q9V8R9

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Lamb et al., 1998, Fehon et al., 1994)

some die during embryonic stage | recessive

(Lamb et al., 1998, Fehon et al., 1994)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Lamb et al., 1998)

embryonic/first instar larval cuticle | dorsal

(Lamb et al., 1998)

embryonic/larval salivary gland | embryonic stage

(Lamb et al., 1998)

embryonic dorsal epidermis

(Fehon et al., 1994)

Detailed Description

Statement

Reference

Embryos show defects in paracellular barrier function in the trachea in a dextran injection assay.

(Ile et al., 2012)

cora¹ homozygous mutants have an effective paracellular diffusion barrier in the embryonic salivary gland.

(Genova and Fehon, 2003)

Homozygous embryos have a faint cuticle and a dorsal scab. The remains of the salivary glands are present as necrotic material. No adult escapers are produced.

(Lamb et al., 1998)

Abnormality in dorsal closure, leaving a small scab on the dorsal side.

(Fehon et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cora¹ is a suppressor of visible | dominant phenotype of Egfr^E1

(Lamb et al., 1998)

Phenotype Manifest In

Suppressor of

Statement

Reference

cora¹ is a suppressor of eye phenotype of Egfr^E1

(Lamb et al., 1998)

cora[+]/cora¹ is a suppressor of eye phenotype of Egfr^E1

(Fehon et al., 1994)

Other

Statement

Reference

Atpα^unspecified, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora¹/cora², nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Atpα^unspecified/Atpalpha[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

cora¹/cora², nrv2[+]/nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Nrx-IV¹⁴/Nrx-IV[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype

(Genova and Fehon, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

cora¹/cora² mutant embryos have an effective diffusion barrier in the embryonic salivary glands that is disrupted when Nrx-IV¹⁴/+, nrv2^unspecified/+ or Atpα^unspecified/+ is present.

(Genova and Fehon, 2003)

Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is wild type in size with some roughening.

(Lamb et al., 1998)

Partially suppresses Egfr^E1 eye phenotype.

(Fehon et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cora¹¹

(Lamb et al., 1998)

cora¹²

(Lamb et al., 1998)

cora¹³

(Lamb et al., 1998)

cora¹⁴

(Lamb et al., 1998)

cora¹⁵

(Lamb et al., 1998)

cora³

(Lamb et al., 1998)

cora⁷

(Lamb et al., 1998)

cora⁸

(Lamb et al., 1998)

cora⁹

(Lamb et al., 1998)

cora¹⁰

(Lamb et al., 1998)

cora⁵

(Lamb et al., 1998)

cora⁶

(Lamb et al., 1998)

cora⁴

(Lamb et al., 1998)

Rescued by

cora¹ is rescued by cora^1.Ubi-p63E

(Lamb et al., 1998)

cora¹ is rescued by cora^1.Ubi-p63E

(Fehon et al., 1994)

Comments

cora¹/cora² mutant embryos have an effective diffusion barrier in the embryonic salivary glands.

(Genova and Fehon, 2003)

Lethality rescued by cora^1.Ubi-p63E.

(Fehon et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 3 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

L27467

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB59187

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V8R9

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cor¹

(Genova and Fehon, 2003, Lamb et al., 1998)

cora¹

(Byri et al., 2015, Tonning et al., 2005)

Name Synonyms

coracle1

(Ile et al., 2012)

Secondary FlyBase IDs

References (6)

Report Sections

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