FlyBase Gene Report: Dmel\Bruce

General Information

Symbol

Dmel\Bruce

Species

D. melanogaster

Name

BIR repeat containing ubiquitin-conjugating enzyme

Annotation Symbol

CG6303

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266717

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

E2 ubiquitin-conjugating enzyme (2.3.2.23)

Gene Summary

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dBruce, mod86

Key Links

Genomic Location

Cytogenetic map

86A7-86A8

Sequence location

3R:10,312,039..10,331,353 [-]

Recombination map

3-49

RefSeq locus

NT_033777 REGION:10312039..10331353

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ubiquitin conjugating enzyme activity

inferred from direct assay

(Song and Ma, 2023, Domingues and Ryoo, 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ubiquitin conjugating enzyme activity

inferred from biological aspect of ancestor with PANTHER:PTN008183954

(GO Reference Genome Project, 2011-)

enables ubiquitin-protein transferase activity

inferred from electronic annotation with InterPro:IPR022103

(InterPro Project Members, 2004-)

Biological Process (13 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in cellular response to starvation

inferred from mutant phenotype

(Hou et al., 2008)

involved_in negative regulation of apoptotic process

inferred from direct assay

(Domingues and Ryoo, 2012)

involved_in negative regulation of hippo signaling

inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970

(Song and Ma, 2023)

involved_in negative regulation of macroautophagy

inferred from mutant phenotype

(Hou et al., 2008)

involved_in negative regulation of nurse cell apoptotic process

inferred from mutant phenotype

(Nezis et al., 2010)

involved_in oogenesis

inferred from mutant phenotype

(Hou et al., 2008)

involved_in programmed cell death

inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706

(Vernooy et al., 2002)

inferred from genetic interaction with FLYBASE:grim; FB:FBgn0015946

(Vernooy et al., 2002)

involved_in proteasome-mediated ubiquitin-dependent protein catabolic process

inferred from genetic interaction with FLYBASE:POSH; FB:FBgn0040294

(Song and Ma, 2023)

involved_in protein polyubiquitination

inferred from mutant phenotype

(Domingues and Ryoo, 2012)

involved_in spermatid development

inferred from mutant phenotype

(Arama et al., 2003)

involved_in ubiquitin-dependent protein catabolic process

inferred from mutant phenotype

(Domingues and Ryoo, 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in apoptotic process

inferred from electronic annotation with InterPro:IPR022103

(InterPro Project Members, 2004-)

involved_in negative regulation of apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000799330

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with MGI:MGI:1276108

(Vernooy et al., 2000)

involved_in regulation of cytokinesis

inferred from electronic annotation with InterPro:IPR022103

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000799330

(GO Reference Genome Project, 2011-)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN001295674

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES

INHIBITOR OF APOPTOSIS

Pathway (FlyBase)

NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ubiquitin conjugating enzyme activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine (2.3.2.23)

Summaries

Gene Snapshot

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES -: Ubiquitin-conjugating (E2) enzymes accept activated ubiquitin from ubiquitin-activating (E1) enzymes via thioester bond with a conserved catalytic cysteine. E2s then interact with ubiquitin ligases (E3) to directly or indirectly ubiquitinate target proteins. E2s are characterised by a 200 amino acid ubiquitin-conjugating (UBC) domain which interacts with E1 and E3s and acts catalytically. (Adapted from PMID:19940261.)
INHIBITOR OF APOPTOSIS -: Inhibitor of APoptosis (IAP) proteins are defined by the presence of one or more BIR (baculoviral IAP repeat) domains. Not all IAPs inhibit apoptosis, but some interact with and inhibit caspases via their BIR domains. This interaction is displaced by RHG protein binding. (Adapted from FBrf0215539).

Pathway (FlyBase)

NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).

Summary (Interactive Fly)

a large protein that contains an N-terminal baculovirus IAP repeat (BIR) and a C-terminal ubiquitin conjugation domain - participates in regulation of apoptosis and autophagy

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Bruce for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KG50)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Bruce-RA

FBtr0082239

NM_141738

15402

4876

Bruce-RB

FBtr0331681

NM_001275531

15702

4976

Bruce-RC

FBtr0331682

NM_001275532

15330

4852

Bruce-RD

FBtr0331683

NM_001275533

15399

4875

Bruce-RE

FBtr0331684

NM_001275534

15369

4865

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Bruce-PA

FBpp0081717

539.2

4876

5.26

FBpp0304070

550.3

4976

5.44

FBpp0304071

536.5

4852

5.29

FBpp0304072

539.1

4875

5.26

FBpp0304073

537.9

4865

5.26

A0A0B4KFQ0

NP_001262463

AGB95845

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bruce using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bruce_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

testis

(Misra et al., 2017)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Bruce in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Bruce

View exonic expression by tissue for Dmel\Bruce

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266717

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41260/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266717

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037808

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266717

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6303

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Bruce

Transgenic constructs containing regulatory region of Bruce

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6156

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^tin.CΔ4

Bruce^GD16949

Other Phenotypes

Allele

increased cell death

increased cell death | adult stage

wild-type

Bruce^RNAi.GMR

Phenotype manifest in

Allele

egg chamber

female germline cyst

germarium region 2

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\BIRC6

13 of 14

Yes

Hsap\BIRC5

3 of 14

Hsap\UBE2Z

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Birc6

13 of 14

Yes

Rnor\Birc5

3 of 14

Rnor\Ube2z

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Birc6

13 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\birc6

11 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\birc2

1 of 13

Xtro\birc7

1 of 13

Xtro\LOC100492519

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (20)

Drer\birc6

13 of 14

Yes

Drer\birc5b

3 of 14

Drer\ube2z

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\ubc-17

7 of 14

Yes

4 of 14

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP002651

12 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\PHO2

3 of 13

Yes

Atha\UBC23

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G62370

1 of 13

Yes

Atha\AT2G21380

1 of 13

Atha\AT2G27950

1 of 13

Atha\AT4G03965

1 of 13

Yes

Atha\AT4G39050

1 of 13

Atha\AT5G23110

1 of 13

Yes

Atha\BRG2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\BIR1

1 of 13

Yes

Scer\RAD6

1 of 13

Yes

Scer\UBC1

1 of 13

Yes

Scer\UBC4

1 of 13

Yes

Scer\UBC5

1 of 13

Yes

Scer\UBC7

1 of 13

Yes

Scer\UBC9

1 of 13

Yes

Scer\UBC13

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\bir1

3 of 12

Yes

Spom\rhp6

1 of 12

Spom\ubc4

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Bruce. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

Det

4 of 13

Diap2

3 of 13

CG10254

2 of 13

Diap1

2 of 13

ben

1 of 13

CG3473

1 of 13

CG17019

1 of 13

dnr1

1 of 13

eff

1 of 13

mib2

1 of 13

Ubc6

1 of 13

Ubc10

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BIRC6; baculoviral IAP repeat containing 6

13 of 14

605638

BIRC5; baculoviral IAP repeat containing 5

3 of 14

603352

UBE2Z; ubiquitin conjugating enzyme E2 Z

3 of 14

611362

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Bruce - Diap1

enzymatic study, western blot

(Yoo, 2005)

Bruce - klhl10

anti tag coimmunoprecipitation, western blot

(Arama et al., 2007)

Bruce - rpr

pull down, anti tag western blot

(Domingues and Ryoo, 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

grim

enhanceable

Bruce

(Vernooy et al., 2002)

grim

suppressible

Bruce

(Vernooy et al., 2002)

hid

suppressible

Bruce

(Domingues and Ryoo, 2012)

rpr

suppressible

Bruce

(Domingues and Ryoo, 2012, Vernooy et al., 2002)

rpr

enhanceable

Bruce

(Domingues and Ryoo, 2012, Ryoo et al., 2002, Vernooy et al., 2002)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266717

MIST (genetic) - An integrated Molecular Interaction Database

41260

MIST (protein-protein) - An integrated Molecular Interaction Database

41260

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-49

Cytogenetic map

86A7-86A8

Sequence location

3R:10,312,039..10,331,353 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86A7-86A8

Limits computationally determined from genome sequence between P{EP}Fmr1^EP3517&P{PZ}tws⁰²⁴¹⁴ and P{PZ}jumu⁰⁶⁴³⁹&P{lacW}l(3)j8B6^j8B6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-49

(FlyBase, 2016)

3-46.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17911

w¹¹¹⁸; PBac{RB}Bruce^e00984/TM6B, Tb¹

605482

y¹ w^*; TI{CRIMIC.TG4.1}Bruce^{CR71241-TG4.1}/TM3, Sb¹ Ser¹

51814

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03385}attP2/TM3, Sb¹ Ser¹

Korea

11463

P{EP}Bruce^G11428

Kyoto

200507

y¹ w^67c23; P{GSV1}sle^GS3144/TM3, Sb¹ Ser¹

NIG-Fly

6303R-1

P{NIG.6303R}1

6303R-2

P{NIG.6303R}2

HMC03385

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03385}attP2/TM3, Sb¹

VDRC

v107620

P{KK100132}VIE-260B

v48309

w¹¹¹⁸; P{GD16949}v48309/CyO

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (191)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266717

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kaplan et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Bruce can inhibit cell death induced by grim and rpr but not W.

(Vernooy et al., 2002)

Alleles of this locus enhance the rpr and grim dependent eye phenotypes while most have little or no effect on the W induced phenotype.

(Agapite et al., 2000)

Relationship to Other Genes

Source for database merge of

Source for merge of: Bruce mod86

(Ryoo et al., 2002)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Bruce CG6303

(Vernooy et al., 2000, Vernooy et al., 2000)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

BRUCE

(Domingues and Ryoo, 2012)

CG6303

(El Fissi et al., 2024, Walls et al., 2013, Ying et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Laviolette et al., 2005, Vernooy et al., 2000, Vernooy et al., 2000)

bruce

(Jonchère et al., 2017, Misra et al., 2017, Ryoo et al., 2002, Ryoo et al., 2002)

dBRUCE

(Vernooy et al., 2000, Vernooy et al., 2000)

dBruce

(Augière et al., 2019, Nakajima and Kuranaga, 2017, Kuleesha et al., 2016, Fabian and Brill, 2012, Nezis, 2012, Gafuik and Steller, 2011, Kuranaga, 2011, Kaplan et al., 2010, Nezis et al., 2010, Xu et al., 2009, Orihara-Ono et al., 2005, Yoo, 2005, Arama et al., 2003, Baehrecke, 2003, Bergmann et al., 2003, Arama et al., 2001)

dbruce

(Gafuik and Steller, 2011, Arama et al., 2007, Arama et al., 2002)

mod86

(Ryoo et al., 2002)

Name Synonyms

BIR repeat containing ubiquitin-conjugating enzyme

(Steller et al., 2014.7.9)

Bruce

(Repton et al., 2022, Wasbrough et al., 2010, Carbone et al., 2009, Peschel et al., 2009)

dbruce

(Rathke et al., 2007)

mod86

Secondary FlyBase IDs

FBgn0037808
FBgn0041108

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41260

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KG50

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KG50

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266717

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41260/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266717

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266717

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6303

MARRVEL_MODEL - MARRVEL (model organism gene)

41260

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266717

DroID - A comprehensive database of gene and protein interactions.

FBgn0266717

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bruce_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037808

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266717

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6303

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009848

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

41260

MIST (protein-protein) - An integrated Molecular Interaction Database

41260

References (93)

The following external sites may use different assemblies or annotations than FlyBase.

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