FB2026_02 , released June 18, 2026
Gene Group: E2 UBIQUITIN CONJUGATING ENZYMES
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General Information
Name
E2 UBIQUITIN CONJUGATING ENZYMES
Species
D. melanogaster
Symbol
E2
FlyBase ID
FBgg0000137
Date last reviewed
2014-07-10
Number of members
27
Description
Description
Ubiquitin-conjugating (E2) enzymes accept activated ubiquitin from ubiquitin-activating (E1) enzymes via thioester bond with a conserved catalytic cysteine. E2s then interact with ubiquitin ligases (E3) to directly or indirectly ubiquitinate target proteins. E2s are characterised by a 200 amino acid ubiquitin-conjugating (UBC) domain which interacts with E1 and E3s and acts catalytically. (Adapted from PMID:19940261.)
Notes on Group
Source Material
The E2 UBIQUITIN CONJUGATING ENZYMES Gene Group has been compiled using the following publication(s): Du et al., 2011, Michelle et al., 2009, Jones et al., 2002, and Pham and Sauer, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin conjugating enzyme activity
Biological Process
protein ubiquitination
Cellular Component
Enzymatic activity
Enzyme name (EC)
E2 ubiquitin-conjugating enzyme (2.3.2.23)
Related Gene Groups
Parent group(s)
UBIQUITIN TRANSFERASES
Other related group(s)
E1 UBIQUITIN-LIKE ACTIVATING ENZYMES
E3 UBIQUITIN LIGASES
UBIQUITIN E2 ENZYME VARIANTS
Members (27)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
E2
UBC
E2 UBIQUITIN CONJUGATING ENZYMES
UBIQUITIN CONJUGATING ENZYMES
Ubiquitin-conjugating enzymes
Secondary FlyBase ID(s)
References (6)