Gene Group: E3 UBIQUITIN LIGASES

General Information

Name

E3 UBIQUITIN LIGASES

Species

D. melanogaster

Symbol

FlyBase ID

FBgg0000069

Date last reviewed

2014-07-10

Number of members

154

Description

E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate.

Notes on Group

Despite their common/historical name, the E3 UBIQUITIN LIGASES are correctly classified as 'transferases' rather than 'ligases'.

The primary subdivisons of the E3 UBIQUITIN LIGASES group follows that in PMID:27015313.

Source Material

The E3 UBIQUITIN LIGASES Gene Group has been compiled using the following publication(s): Washington et al., 2020, Zavortink et al., 2020, Ji et al., 2014, Wisotzkey et al., 2014, Yamazaki et al., 2013, Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, Ying et al., 2011, Marin, 2010, Marin, 2010, Rotin and Kumar, 2009, Rotin and Kumar, 2009, Sardiello et al., 2008, Eisenhaber et al., 2007, and Jin and Harper, 2002 .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin protein ligase activity

Biological Process

protein ubiquitination

Cellular Component

Related Gene Groups

Parent group(s)

UBIQUITIN TRANSFERASES

Component group(s)

HECT UBIQUITIN LIGASES

KCMF1 UBIQUITIN LIGASES