Gene Group: HECT UBIQUITIN LIGASES

General Information

Name

HECT UBIQUITIN LIGASES

Species

D. melanogaster

Symbol

E3-HECT

FlyBase ID

FBgg0000118

Date last reviewed

2014-07-10

Number of members

Description

E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Members of the HECT family of E3 ubiquitin ligases are characterized by a C-terminal HECT domain. This catalytic domain forms an intermediate thioester bond with ubiquitin via a conserved Cys when transferring ubiquitin from the E2 to the target protein. (Adapted from FBrf0225009).

Notes on Group

HECT domain-containing ubiquitin ligases form the second largest class of E3 ligases after RING domain E3s.

The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is approximately 350 amino acids that is found at the C terminus of proteins. It was first described in human papilloma virus E6-associated protein (FBrf0225009).

Source Material

The HECT UBIQUITIN LIGASES Gene Group has been compiled using the following publication(s): Du et al., 2011, Marin, 2010, Rotin and Kumar, 2009, and Rotin and Kumar, 2009 .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin protein ligase activity

Biological Process

protein ubiquitination

Cellular Component

Related Gene Groups

Parent group(s)

E3 UBIQUITIN LIGASES

Members (14)

For all members: