Jin, J., Harper, J.W. (2002). RING finger specificity in SCF-driven protein destruction.  Dev. Cell 2(6): 685--687.

FBrf0155667

Note

SCF ubiquitin ligases contain an E3 core composed of Skp1, Cul1, a member of the Rbx1/Roc1 family of RING finger proteins, and a modular F box protein that functions in substrate targeting. Work published in this issue of Developmental Cell indicates that distinct Rbx1/Roc1 family members are used to control ubiquitination of distinct targets, suggesting that the RING finger subunit may contribute to ubiquitination specificity.