FlyBase Gene Report: Dmel\Roc1b

General Information

Symbol

Dmel\Roc1b

Species

D. melanogaster

Name

Regulator of cullins 1b

Annotation Symbol

CG16988

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040291

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

Gene Summary

Regulator of cullins 1b (Roc1b) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul3 and recruits ubiquitin-charged E2 to the CRL3 E3 ubiquitin ligase complex, which functions during spermatogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

ROC2

Key Links

Genomic Location

Cytogenetic map

61C1-61C1

Sequence location

3L:357,981..358,486 [+]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:357981..358486

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cullin family protein binding

inferred from physical interaction with FLYBASE:Cul3; FB:FBgn0261268

(Reynolds et al., 2008)

enables ubiquitin protein ligase activity

inferred from direct assay

(Reynolds et al., 2008, Noureddine et al., 2002)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables cullin family protein binding

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

enables NEDD8 ligase activity

inferred from sequence or structural similarity with UniProtKB:P62877

(Gene Ontology Curators, 2002-)

enables ubiquitin protein ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR024766

(InterPro Project Members, 2004-)

inferred from sequence model

(Ying et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in lipid storage

inferred from direct assay

(Beller et al., 2008)

involved_in protein ubiquitination

inferred from direct assay

(Reynolds et al., 2008, Noureddine et al., 2002)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell population proliferation

inferred from sequence or structural similarity with UniProtKB:Q9W5E1

(Noureddine et al., 2002)

involved_in protein neddylation

inferred from sequence or structural similarity with UniProtKB:P62877

(Gene Ontology Curators, 2002-)

involved_in protein ubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

involved_in ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of Cul3-RING ubiquitin ligase complex

inferred from direct assay

(Zhou et al., 2015, Zhang et al., 2013, Reynolds et al., 2008, Donaldson et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of cullin-RING ubiquitin ligase complex

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q9W5E1

(Noureddine et al., 2002)

part_of SCF ubiquitin ligase complex

inferred from sequence or structural similarity with UniProtKB:Q9W5E1

(Noureddine et al., 2002)

Gene Group (FlyBase)

ROC UBIQUITIN LIGASES

NEDD8 TRANSFERASES

Protein Family (UniProt)

Belongs to the RING-box family. (Q9NHX0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

NEDD8 ligase activity
ubiquitin protein ligase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

ROC UBIQUITIN LIGASES -: E3 (ubiquitin) ligases interact with ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Roc (Regulator of cullins)/RBX (Ring BoX) proteins are Ring Finger E3 ubiquitin ligases. They form the catalytic subunit of cullin-RING ubiquitin ligase complexes. (Adapted from FBrf0155667).
NEDD8 TRANSFERASES -: NEDD8 transferases catalyse the transfer of the ubiquitin-like protein NEDD8 from one substrate to another. They include NEDD8 conjugating (E2) enzymes and NEDD8 ligase (E3) enzymes, which act sequentially in a process analogous to ubiquitination, and result in covalent attachment of NEDD8 to target proteins. Neddylation results in activation of members of the cullin-RING family of ubiquitin E3 ligases, which appear to be the major NEDD8 targets in the cell. (Adapted from PMID:25531226.)

Protein Function (UniProtKB)

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).

(UniProt, Q9NHX0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Roc1b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9NHX0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Roc1b-RA

FBtr0072547

NM_144356

506

122

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Roc1b-PA

FBpp0072446

14.2

122

4.56

Q9NHX0

NP_652613

AAF47382

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Part of a SCF complex consisting of Skpa (SKP1), Cul1, Roc1B and a F-box protein.

(UniProt, Q9NHX0)

Domain

The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity).

(UniProt, Q9NHX0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9NHX0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Roc1b using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Roc1b_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.85

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Noureddine et al., 2002)

larval stage

wing disc | ubiquitous

(Noureddine et al., 2002)

Additional Descriptive Data

Transcript is detected throughout development by RT-PCR. However, the highest expression levels appear in early embryos, pupae and male bodies. The transcript is expressed uniformly throughout the wing imaginal disc.

(Noureddine et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Cul3-RING ubiquitin ligase complex

inferred from direct assay

(Zhou et al., 2015, Zhang et al., 2013, Reynolds et al., 2008, Donaldson et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Roc1b in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Roc1b

View exonic expression by tissue for Dmel\Roc1b

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040291

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040291

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040291

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040291

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16988

Flygut - An atlas of the Drosophila adult midgut

FBgn0040291

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Roc1b

Transgenic constructs containing regulatory region of Roc1b

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(3L)CRIMIC-CR70684

(Gene Disruption Project members, 2018-)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Sterility

Allele

male semi-sterile

Roc1b^F28M

male sterile

Roc1b^dc3

male sterile (with Df(3L)emc-E12)

Roc1b^F28M

male sterile (with Roc1b^dc3)

Roc1b^F28M

male sterile (with Roc1b^F28M)

Roc1b^dc3

Other Phenotypes

Allele

increased cell death | somatic clone, with Df(1)G1

Roc1b^{Roc1a.Tag:FLAG}

increased cell death | somatic clone, with Df(1)G1, Scer\GAL4^en-e16E

Roc1b^UAS.cDb

Phenotype manifest in

Allele

spermatid

Roc1b^dc3

spermatozoon

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\RBX1

7 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RLIM

1 of 14

Hsap\RNF24

1 of 14

Yes

Hsap\RNF38

1 of 14

Hsap\RNF44

1 of 14

Hsap\RNF122

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Rbx1

6 of 14

Yes

4 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rnf139

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Rbx1

7 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rbx1-ps

1 of 14

Mmus\Rlim

1 of 14

Mmus\Rnf24

1 of 14

Yes

Mmus\Rnf38

1 of 14

Mmus\Rnf122

1 of 14

Yes

Mmus\Rnf139

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\rbx1

3 of 13

Yes

Xtro\rnf7

3 of 13

Yes

Xtro\anapc11

1 of 13

Xtro\ltn1

1 of 13

Xtro\map3k1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\rbx1

7 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

Yes

Drer\rlim

1 of 14

Drer\rnf6

1 of 14

Drer\rnf24

1 of 14

Yes

Drer\rnf38

1 of 14

Drer\rnf44

1 of 14

Drer\rnf122

1 of 14

Yes

Drer\rnf139

1 of 14

Drer\rnf165b

1 of 14

Drer\ttc3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\rbx-1

7 of 14

Yes

4 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\plr-1

1 of 14

Cele\sel-11

1 of 14

Cele\T22B2.1

1 of 14

Yes

Cele\toe-4

1 of 14

Cele\Y54E10A.11

1 of 14

Cele\ZK637.14

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP005202

6 of 12

Yes

4 of 12

3 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013357

1 of 12

Arabidopsis thaliana (thale-cress) (95)

Atha\AT3G42830

7 of 13

Yes

Atha\RBX1

7 of 13

Yes

3 of 13

3 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G60360

1 of 13

Atha\AT1G68070

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G48030

1 of 13

Atha\AT3G54780

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G60710

1 of 13

Yes

Atha\AT5G67120

1 of 13

Atha\ATL1F

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RDUF1

1 of 13

Atha\RDUF2

1 of 13

Atha\RHA1A

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RIN2

1 of 13

Atha\RIN3

1 of 13

Atha\RING1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\HRT1

9 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\rbx1

6 of 12

Yes

Spom\apc11

2 of 12

Spom\SPBC21D10.09c

1 of 12

Spom\SPBP4H10.07

1 of 12

Yes

Spom\SPCC4G3.12c

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Roc1b. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

10 of 13

6 of 13

4 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RBX1; ring-box 1

7 of 14

603814

RNF7; ring finger protein 7

4 of 14

603863

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Roc1b - Cul1

anti bait coimmunoprecipitation, western blot

(Donaldson et al., 2004)

Roc1b - Cul3

anti tag coimmunoprecipitation, western blot, anti tag western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Zhou et al., 2015, Zhang et al., 2013, Reynolds et al., 2008, Donaldson et al., 2004)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Roc1b

suppressible

Roc1a::Roc1b

(Reynolds et al., 2008)

Roc1b

suppressible

Roc1a

(Donaldson et al., 2004)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Part of a SCF complex consisting of Skpa (SKP1), Cul1, Roc1B and a F-box protein.

(UniProt, Q9NHX0 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72732

DroID - A comprehensive database of gene and protein interactions.

FBgn0040291

MIST (protein-protein) - An integrated Molecular Interaction Database

53445

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Nuclear CI is degraded

Class of Gene

nuclear_gene

protein_coding_gene

retrogene

(dos Santos, 2014, Bai et al., 2007, Langille and Clark, 2007)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C1-61C1

Sequence location

3L:357,981..358,486 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C1-61C1

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

61C1-61C3

(Noureddine, 1999.12.21)

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

34486

w^*; P{Roc1b.V5}2

31067

y¹ v¹; P{TRiP.JF01517}attP2

98893

y¹ w¹; P{TKO-UAS.GS06034}attP40/CyO

605231

y¹ v¹; P{SAM.dCas9.GS06315}attP40/CyO

34051

w^*; Roc1b^dc3/TM3, P{ActGFP}JMR2, Ser¹

34048

w^*; P{UAS-Roc1b.D}1/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

62187

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05194}attP40

98605

y¹ w^*; Df(3L)CRIMIC-CR70684 TI{KozakGAL4}Roc1b^{CR70684-KO-kG4}/TM3, Sb¹ Ser¹

FlyORF

F002229

M{UAS-Roc1b.ORF.3xHA.GW}ZH-86Fb

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT21612

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040291

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040291

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes.

(Higa et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: ROC2 CG16988

(Bayraktaroglu, 2000.8.7)

Source for merge of: Roc1b BcDNA:AT21612

(FlyBase, 1996-)

Additional comments

The Roc1b gene may have been derived from the Roc1a gene by retroposition.

(Bai et al., 2007, Langille and Clark, 2007)

Source for merge of Roc1b BcDNA:AT21612 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Roc1b ROC2

(Duronio, 2001.3.7)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BcDNA:AT21612

CG16988

(Hosono et al., 2015, Lin et al., 2015, Ying et al., 2011, Perkins et al., 2009, Ni et al., 2008, Bocca et al., 2001, Duronio, 2001.3.7, Duronio, 2001.3.7)

ROC1B

(Duronio, 2001.3.7)

ROC1b

(Higa et al., 2003)

ROC2

(Duronio, 2001.3.7)

Roc

(Alexandre et al., 2008)

Roc2

(Kohzaki, 2018)

dRoc1b

(Noureddine et al., 2001)

roc1b

(Arama et al., 2007, Bai et al., 2007)

Name Synonyms

Regulator of cullins 1b

Roc1b

Secondary FlyBase IDs

FBgn0035135
FBgn0047337

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

53445

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9NHX0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9NHX0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9NHX0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040291

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040291

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040291

FlyMine - An integrated database for Drosophila genomics

FBgn0040291

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16988

MARRVEL_MODEL - MARRVEL (model organism gene)

53445

Linkouts

BioGRID - A database of protein and genetic interactions.

72732

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040291

DroID - A comprehensive database of gene and protein interactions.

FBgn0040291

DRSC - Results frm RNAi screens

FBgn0040291

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Roc1b_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040291

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040291

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16988

Flygut - An atlas of the Drosophila adult midgut

FBgn0040291

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007016

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

53445

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Nuclear CI is degraded

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

4.85

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