FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term SCF ubiquitin ligase complex ID (Ontology) GO:0019005 (Gene Ontology)
Definition A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).[ PubMed:15571813 PubMed:15688063 ]
Also Known As"CDL1 complex" ; "CRL1 complex" ; "Cul1-RING ubiquitin ligase complex" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 SCF ubiquitin ligase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | SCF ubiquitin ligase complex       --
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  ubiquitin ligase complex
   |__cullin-RING ubiquitin ligase complex
       |__SCF ubiquitin ligase complex  71 rec.
           |__cytoplasmic SCF ubiquitin ligase complex
           |__nuclear SCF ubiquitin ligase complex
           |__SCF-Cdc4 ubiquitin ligase complex
           |__SCF-Ctf13 ubiquitin ligase complex
           |__SCF-Das1 ubiquitin ligase complex
           |__SCF-Dia2/Pof3 ubiquitin ligase complex
           |__SCF-Grr1/Pof2 ubiquitin ligase complex
           |__SCF-Hrt3/Pof7 ubiquitin ligase complex
           |__SCF-Mdm30 ubiquitin ligase complex
           |__SCF-Met30/Pof1 ubiquitin ligase complex
           |__SCF-Pof5 ubiquitin ligase complex
           |__SCF-Rcy1/Pof6 ubiquitin ligase complex
           |__SCF-Saf1/Pof9 ubiquitin ligase complex
           |__SCF-Skp2 ubiquitin ligase complex
           |__SCF-Ucc1 ubiquitin ligase complex
           |__SCF-Ufo1/Pof10 ubiquitin ligase complex
           |__SCF-YDR131C ubiquitin ligase complex
           |__SCF-YLR352W ubiquitin ligase complex
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Is a cullin-RING ubiquitin ligase complex
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Synonyms
  • "CDL1 complex" EXACT
    "CRL1 complex" EXACT
    "Cul1-RING ubiquitin ligase complex" EXACT
    "cullin-RING ligase 1" EXACT
    "SCF complex" EXACT
    "SCF complex substrate recognition subunit" NARROW
    "Skp1/Cul1/F-box protein complex" EXACT
Secondary IDs
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Wikipedia:SCF_complex