FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

cullin-RING ubiquitin ligase complex

ID (Ontology)

GO:0031461 (Gene Ontology)

Definition

Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.[ PubMed:15571813 PubMed:15688063 ]

Also Known As

"CRL complex" ; "cullin complex"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
cullin-RING ubiquitin ligase complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| cullin-RING ubiquitin ligase complex	--

Spanning Tree (Parents/Children)

intracellular protein-containing complex__
transferase complex_______________________|
                                          ubiquitin ligase complex
                                           |__cullin-RING ubiquitin ligase complex  131 rec.
                                               |__anaphase-promoting complex 19 rec.
                                               |__Cul2-RING ubiquitin ligase complex 10 rec.
                                               |__Cul3-RING ubiquitin ligase complex 20 rec.
                                               |__Cul4-RING E3 ubiquitin ligase complex 15 rec.
                                               |   |__CLRC complex
                                               |   |__Cul4A-RING E3 ubiquitin ligase complex 1 rec.
                                               |   |__Cul4B-RING E3 ubiquitin ligase complex
                                               |__Cul5-RING ubiquitin ligase complex 4 rec.
                                               |__Cul7-RING ubiquitin ligase complex
                                               |__Cul8-RING ubiquitin ligase complex
                                               |__SCF ubiquitin ligase complex 71 rec.
                                                   |__cytoplasmic SCF ubiquitin ligase complex
                                                   |__nuclear SCF ubiquitin ligase complex
                                                   |__SCF-Cdc4 ubiquitin ligase complex
                                                   |__SCF-Ctf13 ubiquitin ligase complex
                                                   |__SCF-Das1 ubiquitin ligase complex
                                                   |__SCF-Dia2/Pof3 ubiquitin ligase complex
                                                   |__SCF-Grr1/Pof2 ubiquitin ligase complex
                                                   |__SCF-Hrt3/Pof7 ubiquitin ligase complex
                                                   |__SCF-Mdm30 ubiquitin ligase complex
                                                   |__SCF-Met30/Pof1 ubiquitin ligase complex
                                                   |__SCF-Pof5 ubiquitin ligase complex
                                                   |__SCF-Rcy1/Pof6 ubiquitin ligase complex
                                                   |__SCF-Saf1/Pof9 ubiquitin ligase complex
                                                   |__SCF-Skp2 ubiquitin ligase complex
                                                   |__SCF-Ucc1 ubiquitin ligase complex
                                                   |__SCF-Ufo1/Pof10 ubiquitin ligase complex
                                                   |__SCF-YDR131C ubiquitin ligase complex
                                                   |__SCF-YLR352W ubiquitin ligase complex

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	ubiquitin ligase complex
Part of
Synonyms & Secondary IDs
Synonyms
	"CRL complex" EXACT "cullin complex" EXACT "cullin-RING ligase" RELATED
Secondary IDs

External Crossreferences & Linkouts