FlyBase Gene Report: Dmel\Trc8

General Information

Symbol

Dmel\Trc8

Species

D. melanogaster

Name

TRC8 ring finger protein

Annotation Symbol

CG2304

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039668

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development. (UniProt, Q7KRW1)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DTrc8

Key Links

Genomic Location

Cytogenetic map

99B1-99B1

Sequence location

3R:29,499,025..29,503,797 [-]

Recombination map

3-99

RefSeq locus

NT_033777 REGION:29499025..29503797

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9V3C1

(Gemmill et al., 2002)

inferred from physical interaction with UniProtKB:Q9XZ58

(Gemmill et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ubiquitin protein ligase activity

inferred from sequence or structural similarity with UniProtKB:Q8WU17

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN004563991

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of growth

inferred from mutant phenotype

(Gemmill et al., 2005, Gemmill et al., 2002)

involved_in ventral midline development

inferred from mutant phenotype

(Gemmill et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in proteasome-mediated ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN004563991

(GO Reference Genome Project, 2011-)

involved_in protein ubiquitination

inferred from sequence or structural similarity with UniProtKB:Q8WU17

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Gemmill et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Derlin-1 retrotranslocation complex

inferred from biological aspect of ancestor with PANTHER:PTN000967628

(GO Reference Genome Project, 2011-)

located_in endoplasmic reticulum membrane

inferred from experiment

(Gemmill et al., 2002)

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -: This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

(UniProt, Q7KRW1)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Trc8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KRW1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Trc8-RA

FBtr0085429

NM_170413

3303

804

Trc8-RB

FBtr0085430

NM_170414

3456

804

Trc8-RD

FBtr0085432

NM_206580

3471

809

Trc8-RE

FBtr0333188

NM_001276141

3704

804

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Trc8-PA

FBpp0084797

88.7

804

7.01

FBpp0084798

88.7

804

7.01

FBpp0089379

89.2

809

7.01

FBpp0305390

88.7

804

7.01

A4V3L3

NP_001263070

AGB96450

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

804 aa isoforms: Trc8-PA, Trc8-PB, Trc8-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with VHL. Interacts with the MPN domain of CSN5. Interacts with EIF3F and EIF3H.

(UniProt, Q7KRW1)

Domain

The RING-type zinc finger domain may be essential for ubiquitin ligase activity.

(UniProt, Q7KRW1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Trc8 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Trc8_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.58

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Gemmill et al., 2002)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Trc8 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Trc8

View exonic expression by tissue for Dmel\Trc8

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43476/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039668

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039668

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039668

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2304

Flygut - An atlas of the Drosophila adult midgut

FBgn0039668

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Trc8

Transgenic constructs containing regulatory region of Trc8

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene not disrupted in

Df(3R)Spase12^d4

(Haase Gilbert et al., 2013)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act.PU

Trc8^UAS.Tag:MYC

lethal - all die before end of first instar larval stage, with Scer\GAL4^Act.PU

Trc8^UAS.Tag:MYC

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Trc8^GD358

viable, with Scer\GAL4^Mef2.PR

Trc8^GD358

viable, with Scer\GAL4^pnr-MD237

Trc8^GD358

viable, with Scer\GAL4^tin.CΔ4

Trc8^GD358

Other Phenotypes

Allele

abnormal size, with Scer\GAL4^ap-md544

Trc8^UAS.Tag:MYC

abnormal size, with Scer\GAL4^Bx-MS1096

Trc8^UAS.Tag:MYC

abnormal size, with Scer\GAL4^en.PU

Trc8^UAS.Tag:MYC

some die during first instar larval stage, with Scer\GAL4^Act.PU

Trc8^UAS.Tag:MYC

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PU

Trc8^UAS.Tag:MYC

wing, with Scer\GAL4^ap-md544

Trc8^UAS.Tag:MYC

wing, with Scer\GAL4^Bx-MS1096

Trc8^UAS.Tag:MYC

wing, with Scer\GAL4^en.PU

Trc8^UAS.Tag:MYC

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (22)

Hsap\RNF139

13 of 14

Yes

Hsap\RNF145

4 of 14

Yes

Hsap\AMFR

3 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Rnf139

13 of 14

Yes

Rnor\Rnf145

4 of 14

Yes

Rnor\Syvn1

3 of 14

Rnor\Amfr

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Rnf139

13 of 14

Yes

Mmus\Rnf145

4 of 14

Yes

Mmus\Syvn1

3 of 14

Mmus\Amfr

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\rnf139

10 of 13

Yes

Xtro\rnf145l

2 of 13

Yes

Xtro\rnf145

2 of 13

Yes

Xtro\syvn1

2 of 13

Xtro\amfr

1 of 13

Yes

Xtro\map3k1

1 of 13

Yes

Xtro\rlim

1 of 13

Xtro\rnf7

1 of 13

Xtro\rnf32

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (21)

Drer\rnf139

12 of 14

Yes

Drer\rnf145a

4 of 14

Yes

Drer\rnf145b

4 of 14

Yes

Drer\zmp:0000000662

4 of 14

Yes

Drer\amfra

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch211-207l14.1

1 of 14

Yes

Drer\toporsb

1 of 14

Drer\ttc3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\rnf-145

7 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\ZC13.1

1 of 14

Cele\ZK637.14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP003666

12 of 12

Yes

Agam\AgaP_AGAP003179

3 of 12

Agam\AgaP_AGAP007538

3 of 12

Yes

Agam\AgaP_AGAP001358

1 of 12

Agam\AgaP_AGAP003558

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (112)

Atha\RIN2

4 of 13

Yes

Atha\RIN3

4 of 13

Yes

Atha\Hrd1A

3 of 13

Atha\Hrd1B

3 of 13

Atha\AT4G05350

2 of 13

Yes

Atha\AT4G12140

2 of 13

Yes

Atha\AT4G12190

2 of 13

Yes

Atha\AT4G12210

2 of 13

Yes

Atha\AIRP1

1 of 13

Atha\APC11

1 of 13

Atha\AT1G08050

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G63840

1 of 13

Yes

Atha\AT1G65032

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G31450

1 of 13

Atha\AT4G32600

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G41430

1 of 13

Atha\AT5G41440

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G66070

1 of 13

Yes

Atha\AT5G67120

1 of 13

Atha\ATL1F

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RHA1B

1 of 13

Atha\RHA2B

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\APC11

1 of 13

Yes

Scer\ETP1

1 of 13

Yes

Scer\HRD1

1 of 13

Yes

Scer\HRT1

1 of 13

Yes

Scer\JHD2

1 of 13

Yes

Scer\RKR1

1 of 13

Yes

Scer\SAN1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\hrd1

2 of 12

Yes

Spom\dsc1

1 of 12

Yes

Spom\SPCC4G3.12c

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Trc8. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

4 of 13

3 of 13

1 of 13

1 of 13

gol

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

RNF139; ring finger protein 139

model of nonpapillary renal cell carcinoma

IEA

(FlyBase, 2019-)

AMFR; autocrine motility factor receptor

model of hereditary spastic paraplegia 89

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RNF139; ring finger protein 139

13 of 14

603046

RENAL CELL CARCINOMA, NONPAPILLARY; RCC

nonpapillary renal cell carcinoma

RNF145; ring finger protein 145

4 of 14

620640

AMFR; autocrine motility factor receptor

3 of 14

603243

SPASTIC PARAPLEGIA 89, AUTOSOMAL RECESSIVE; SPG89

hereditary spastic paraplegia 89

SYVN1; synoviolin 1

3 of 14

608046

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Trc8 - CSN5

two hybrid, pull down, autoradiography, western blot

(Lee et al., 2010, Gemmill et al., 2005, Gemmill et al., 2002)

Trc8 - Vhl

anti bait coimmunoprecipitation, anti tag western blot, pull down, western blot

(Gemmill et al., 2002)

Trc8 - eIF3f1

pull down, autoradiography

(Lee et al., 2010)

Trc8 - eIF3h

pull down, autoradiography

(Lee et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Trc8

suppressible

CSN5

(Gemmill et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with VHL. Interacts with the MPN domain of CSN5. Interacts with EIF3F and EIF3H.

(UniProt, Q7KRW1 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68341

DroID - A comprehensive database of gene and protein interactions.

FBgn0039668

MIST (genetic) - An integrated Molecular Interaction Database

43476

MIST (protein-protein) - An integrated Molecular Interaction Database

43476

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99B1-99B1

Sequence location

3R:29,499,025..29,503,797 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B1-99B1

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-96.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

76561

y¹ sc^* v¹ sev²¹; P{TKO.GS01012}attP40

56890

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04111}attP40

20622

y¹ w^67c23; P{wHy}Trc8^DG12812/TM3, Sb¹ Ser¹

2304R-2

v105287

v4449

w¹¹¹⁸; P{GD358}v4449/TM3

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039668

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039668

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

8% of embryos treated with Trc8 dsRNA (to induce RNAi) reveal a narrow gap in the denticle pattern along the ventral midline.

(Gemmill et al., 2002)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of Trc8 CG2304 was sequence comparison ( date:020710 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Trc8 CG2304

(FlyBase, 1996-)

Nomenclature comments

Etymology

Named 'Trc8' after the human ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG2304

(Ying et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Zinke et al., 2002, Milan et al., 2001)

DTrc8

(Lee et al., 2010, Gemmill et al., 2005, Gemmill et al., 2002)

Dtrc8

(Gemmill et al., 2002, Bemis, 2001.5.31)

TRC8

(Bemis, 2001.5.31)

Trc8

(Transgenic RNAi Project members, 2017-, Ashwal-Fluss et al., 2014, Korenjak et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Korenjak et al., 2012, Langley et al., 2012, Du et al., 2011, Jiang et al., 2009, Adryan et al., 2007)

trc8

(Kim et al., 2018)

Name Synonyms

TRC8 ortholog

TRC8 ring finger protein

Trc8

Secondary FlyBase IDs

FBgn0062836

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43476

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KRW1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KRW1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A4V3L3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KRW1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43476/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039668

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039668

FlyMine - An integrated database for Drosophila genomics

FBgn0039668

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2304

MARRVEL_MODEL - MARRVEL (model organism gene)

43476

Linkouts

BioGRID - A database of protein and genetic interactions.

68341

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039668

DroID - A comprehensive database of gene and protein interactions.

FBgn0039668

DRSC - Results frm RNAi screens

FBgn0039668

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Trc8_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039668

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039668

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2304

Flygut - An atlas of the Drosophila adult midgut

FBgn0039668

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012749

MIST (genetic) - An integrated Molecular Interaction Database

43476

MIST (protein-protein) - An integrated Molecular Interaction Database

43476

References (44)

The following external sites may use different assemblies or annotations than FlyBase.

4.58

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