FB2026_03 , released September 17, 2026
Gene Group: ROC UBIQUITIN LIGASES
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General Information
Name
ROC UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
E3-ROC
FlyBase ID
FBgg0000062
Date last reviewed
2014-07-10
Number of members
3
Description
Description
E3 (ubiquitin) ligases interact with ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Roc (Regulator of cullins)/RBX (Ring BoX) proteins are Ring Finger E3 ubiquitin ligases. They form the catalytic subunit of cullin-RING ubiquitin ligase complexes. (Adapted from FBrf0155667).
Notes on Group
Source Material
The ROC UBIQUITIN LIGASES Gene Group has been compiled using the following publication(s): Du et al., 2011, Ying et al., 2011, and Jin and Harper, 2002 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin protein ligase activity
Biological Process
protein ubiquitination
Cellular Component
cullin-RING ubiquitin ligase complex
Related Gene Groups
Parent group(s)
RING DOMAIN E3 UBIQUITIN LIGASES
Other related group(s)
CULLINS
F BOX PROTEINS
SKP1 GENE FAMILY
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
E3-ROC
ROC UBIQUITIN LIGASES
Regulator of cullins
Ring Box
Ring-box
Roc
RBX
Secondary FlyBase ID(s)
References (5)