FB2026_02 , released June 18, 2026
Gene: Hsap\CASP1
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General Information
Symbol
Hsap\CASP1
Species
H. sapiens
Name
caspase 1, apoptosis-related cysteine peptidase
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0024349
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ICE

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == CASP1; HGNC:1499.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\CASP1
Transgenic constructs containing regulatory region of Hsap\CASP1
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage, with Scer\GAL411H-1
lethal - all die before end of pupal stage, with Scer\GAL4389
lethal - all die before end of pupal stage, with Scer\GAL4ptc-559.1
lethal - all die during larval stage, with Scer\GAL4srp.D.cCa
lethal - all die during pupal stage, with Scer\GAL4Hml.PG
lethal - all die during pupal stage, with Scer\GAL4Pxn.PS
partially lethal - majority die, with Scer\GAL4sca-537.4
Other Phenotypes
Allele
abnormal immune response, with Scer\GAL4Hml.PG
increased cell death, with Scer\GAL4sca-537.4
some die during larval stage, with Scer\GAL411H-1
some die during pupal stage, with Scer\GAL4389
some die during pupal stage, with Scer\GAL4ptc-559.1
Phenotype manifest in
Allele
embryonic/larval hemocyte, with Scer\GAL4Hml.PG
embryonic/larval hemocyte, with Scer\GAL4Pxn.PS
embryonic/larval hemocyte, with Scer\GAL4srp.D.cCa
embryonic/larval lymph gland, with Scer\GAL4Hml.PG
embryonic/larval lymph gland, with Scer\GAL4Pxn.PS
macrochaeta | pharate adult stage, with Scer\GAL4sca-537.4
prothoracic gland, with Scer\GAL411H-1
ring gland, with Scer\GAL411H-1
wing disc, with Scer\GAL4389
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (7)
Dcp-1
3 of 14
Yes
No
0  
Decay
3 of 14
Yes
No
0  
Dredd
3 of 14
Yes
Yes
0  
Drice
3 of 14
Yes
No
0  
Dronc
3 of 14
Yes
No
0  
Damm
2 of 14
No
Yes
0  
Strica
2 of 14
No
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments

A mechanism of programmed cell death controlled by CED-3/ICE is conserved among widely divergent animal species including Drosophila, and the system provides a tool to dissect cell death mechanism of CED-3/ICE proteases.

(Shigenaga et al., 1997)

Hsap\CASP1 can elicit cell death in various cells types. The Hsap\CASP1 expression pattern corresponds to the region where the resulting morphological defect is observed.

(Shigenaga et al., 1997)
Relationship to Other Genes
Source for database merge of
Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (13)
Reported As
Symbol Synonym
CASP1
(HGNC Curators and FlyBase Curators, 2013-)
Casp1
(Morris et al., 2006)
Hsap\CASP1
ICE
(HGNC Curators and FlyBase Curators, 2013-, Shia et al., 2009, Shigenaga et al., 1997)
IL1BC
(HGNC Curators and FlyBase Curators, 2013-)
Name Synonyms
Caspase 1
Interleukin-1β Converting Enzyme
(Shigenaga et al., 1997)
caspase 1
(HGNC Curators and FlyBase Curators, 2013-)
caspase 1, apoptosis-related cysteine peptidase
(HGNC Curators and FlyBase Curators, 2013-)
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
(HGNC Curators and FlyBase Curators, 2013-)
caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
(HGNC Curators and FlyBase Curators, 2013-)
caspase-1
(HGNC Curators and FlyBase Curators, 2013-)
interleukin 1, beta, convertase
(HGNC Curators and FlyBase Curators, 2013-)
Secondary FlyBase IDs
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 5 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    Ensembl_Homo_sapiens -
    HUGO Gene Nomenclature Committee -
    MARRVEL - MARRVEL (human gene)
    OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
    References (6)