FlyBase Gene Report: Dmel\Fadd

General Information

Symbol

Dmel\Fadd

Species

D. melanogaster

Name

Fas-associated death domain

Annotation Symbol

CG12297

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038928

Gene Model Status

Stock Availability

9 publicly available

Gene Summary

Fas-associated death domain (Fadd) encodes an adaptor protein that functions downstream of the product of imd and upstream of the caspase encoded by Dredd in the immune deficiency pathway. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
UniProtKB
Interactive Fly

Also Known As

dFADD, BG4

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:22,034,455..22,035,617 [+]

Recombination map

3-74

RefSeq locus

NT_033777 REGION:22034455..22035617

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables CARD domain binding

inferred from physical interaction with FLYBASE:Dredd; FB:FBgn0020381

(Hu and Yang, 2000)

enables protein binding

inferred from physical interaction with UniProtKB:Q7K4Z4

(assigned by UniProt )

(Naitza et al., 2002)

inferred from physical interaction with UniProtKB:Q8IRY7

(assigned by UniProt )

(Hu and Yang, 2000)

inferred from physical interaction with FLYBASE:Myd88; FB:FBgn0033402

(Horng and Medzhitov, 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables caspase binding

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

enables death receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (11 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process

inferred from direct assay

(Hu and Yang, 2000)

involved_in apoptotic process

inferred from mutant phenotype

(assigned by UniProt )

(Hu and Yang, 2000)

involved_in defense response to Gram-negative bacterium

inferred from mutant phenotype

(Berkey et al., 2009)

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

inferred from genetic interaction with FLYBASE:PGRP-LE; FB:FBgn0030695

(Libert et al., 2006)

inferred from mutant phenotype

(assigned by UniProt )

(Naitza et al., 2002)

involved_in immune response

inferred from mutant phenotype

(Leulier et al., 2002)

involved_in peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Paquette et al., 2010, Ertürk-Hasdemir et al., 2009, Zhou et al., 2005)

inferred from genetic interaction with FLYBASE:imd; FB:FBgn0013983

(Naitza et al., 2002)

involved_in positive regulation of defense response to virus by host

inferred from mutant phenotype

(Avadhanula et al., 2009)

involved_in positive regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in sperm individualization

inferred from mutant phenotype

(Huh et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in positive regulation of antibacterial peptide biosynthetic process

traceable author statement

(Brennan and Anderson, 2004)

involved_in positive regulation of extrinsic apoptotic signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in TRAIL-activated apoptotic signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(assigned by UniProt )

(Hu and Yang, 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of CD95 death-inducing signaling complex

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002688310

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Pathway (FlyBase)

Imd Signaling Pathway Core Components

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Fas-associated death domain (Fadd) encodes an adaptor protein that functions downstream of the product of imd and upstream of the caspase encoded by Dredd in the immune deficiency pathway. [Date last reviewed: 2019-03-07]

Pathway (FlyBase)

Imd Signaling Pathway Core Components -: The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)

Protein Function (UniProtKB)

Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

(UniProt, Q9V3B4)

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Fadd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0084176

1163

239

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0083574

27.4

239

6.17

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via N-terminus) with Dredd; likely to bind Dredd simultaneously with Diap2 to form a trimeric complex (PubMed:10934188, PubMed:22549468). Interacts with imd (PubMed:12433364).

(UniProt, Q9V3B4)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9V3B4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fadd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fadd_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult Malpighian tubule

(McGettigan et al., 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(assigned by UniProt )

(Hu and Yang, 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Fadd in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fadd

View exonic expression by tissue for Dmel\Fadd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0038928

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG12297-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0038928

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fadd

Transgenic constructs containing regulatory region of Fadd

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fadd^GD1717

viable, with Scer\GAL4^Mef2.PR

Fadd^GD1717

viable, with Scer\GAL4^pnr-MD237

Fadd^GD1717

Sterility

Allele

Other Phenotypes

Allele

abnormal immune response

abnormal immune response, with Scer\GAL4^c564

Fadd^dsRNA.UAS

abnormal immune response, with Scer\GAL4^da.G32

Fadd^dsRNA.UAS

abnormal immune response, with Scer\GAL4^yolk

abnormal immune response (with Df(3R)93F^x2)

Fadd^EY10870

abnormal immune response | recessive

Fadd^EY10870

wild-type, with Scer\GAL4^da.G32

Fadd^dsRNA.UAS

Phenotype manifest in

Allele

Fadd^f02804

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

4 of 15

Yes

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

3 of 15

Yes

Yes

Rattus norvegicus (Norway rat) (1)

4 of 13

Yes

Yes

Xenopus tropicalis (Western clawed frog) (1)

3 of 12

Yes

Yes

Danio rerio (Zebrafish) (1)

3 of 15

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FCV )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011620

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150ARU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY007803

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05986

Aedes aegypti

Yellow fever mosquito

Anopheles darlingi

American malaria mosquito

Adar\ADAC008782

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009900

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AUM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000311

Danaus plexippus

Monarch butterfly

Dple\DPOGS207960-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014329

Apis florea

Little honeybee

Aflo\2240000420

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002487

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010611

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008197

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Rhodnius prolixus

Kissing bug

Rpro\RPRC013858

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06474

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ARJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007362

Strigamia maritima

European centipede

Smar\SMAR000613

Strigamia maritima

European centipede

Smar\SMAR003728

Ixodes scapularis

Black-legged tick

Isca\ISCW017523

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77430.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310111

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310110

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GZR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_014234gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_002591gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_509

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2872

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028799gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_92

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000332gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2724

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_736

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_501

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1065

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_425

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020037gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2536

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021115

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FADD; Fas associated via death domain

4 of 15

INFECTIONS, RECURRENT, WITH ENCEPHALOPATHY, HEPATIC DYSFUNCTION, AND CARDIOVASCULAR MALFORMATIONS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Guntermann et al., 2015, Meinander et al., 2012, Guntermann and Foley, 2011)

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Fukuyama et al., 2012, Meinander et al., 2012, Guntermann and Foley, 2011, Horng and Medzhitov, 2001, Hu and Yang, 2000)

anti tag coimmunoprecipitation, anti tag western blot

(Horng and Medzhitov, 2001)

anti tag coimmunoprecipitation, anti tag western blot, two hybrid, anti bait coimmunoprecipitation

(Petkau et al., 2017, Guntermann and Foley, 2011, Naitza et al., 2002)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Tang et al., 2006)

enhanceable

(Tang et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Libert et al., 2006)

suppressible

(González and Busturia, 2009)

External Data

Subunit Structure (UniProtKB)

Interacts (via N-terminus) with Dredd; likely to bind Dredd simultaneously with Diap2 to form a trimeric complex (PubMed:10934188, PubMed:22549468). Interacts with imd (PubMed:12433364).

(UniProt, Q9V3B4 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67555

DroID - A comprehensive database of gene and protein interactions.

FBgn0038928

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42594

MIST (protein-protein) - An integrated Molecular Interaction Database

Fadd

Pathways

Signaling Pathways (FlyBase)

Imd Signaling Pathway Core Components -: The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-74

Cytogenetic map

Sequence location

3R:22,034,455..22,035,617 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A1-94A1

Limits computationally determined from genome sequence between P{PZ}tsl⁰⁰⁶¹⁷ and P{lacW}how^j5B5&P{EP}EP738

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-74

(FlyBase, 2016)

3-76.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

19026

w¹¹¹⁸; PBac{WH}Fadd^f06954 pit^f06954

62741

w¹¹¹⁸; PBac{IT.GAL4}Fadd^0258-G4 pit^0258-G4

83534

y¹ sc^* v¹ sev²¹; P{TKO.GS04305}attP40

34813

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00123}attP2

20638

y¹ w^67c23; P{EPgy2}Fadd^EY10870 pit^EY10870

20904

y¹ w^67c23; P{EPgy2}Fadd^EY14017 pit^EY14017

F002899

M{UAS-Fadd.ORF.3xHA.GW}ZH-86Fb

v100333

P{KK105956}VIE-260B

v7926

w¹¹¹⁸; P{GD1717}v7926/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038928

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038928

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42594

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: BG4 CG12297

(FlyBase, 1996-)

Source for identity of: Fadd BG4

(FlyBase, 2009-)

Source for database merge of

Additional comments

FlyBase curator comment: 'BG4' renamed to 'Fadd' because: i) this reflects the overwhelming usage in the literature; ii) the first published paper (FBrf0129865) on this gene referred to it as 'dFADD'; iii) 'BG4' does not convey any useful information - it's unclear/unknown from where this symbol derives.

(FlyBase, 2009-)

Source for identity of BG4 CG12297 was sequence comparison ( date:000327 ).

(FlyBase, 1996-)

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

BG4 has a role in the regulation of the antibacterial response.

(Leulier et al., 2002)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42594

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3B4

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038928

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fadd_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0038928

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

205590

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42594

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014042

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12297

modMine - A data warehouse for the modENCODE project

FBgn0038928

Linkouts

BioGRID - A database of protein and genetic interactions.

67555

DroID - A comprehensive database of gene and protein interactions.

FBgn0038928

DRSC - Results frm RNAi screens

FBgn0038928

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0038928

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG12297-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038928

FlyMine - An integrated database for Drosophila genomics

FBgn0038928

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42594

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Fadd

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BG4

(Fukuyama et al., 2013, Fukuyama et al., 2012, Rynes et al., 2012, Hill-Burns and Clark, 2010, Zsindely et al., 2009, Carrera et al., 2008, Liu and Lehmann, 2008, Tsichritzis et al., 2007)

BG4_DROME

(Fukuyama et al., 2012)

CG12297

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Morales-Hojas et al., 2009, Carrera et al., 2008)

Fadd

(Zugasti et al., 2020, Masuzzo et al., 2019, Behrman et al., 2018, Kounatidis and Chtarbanova, 2018, Zhai et al., 2018, Christesen et al., 2017, Kurz et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Orme et al., 2016, Xia et al., 2015, Keebaugh and Schlenke, 2014, Cronin et al., 2009, Goto et al., 2008, Huh et al., 2004)

dFADD

(Goto et al., 2018, Palmer et al., 2018, Kleino and Silverman, 2014, Xu and Cherry, 2014, Fukuyama et al., 2013, Kingsolver et al., 2013, Merkling and van Rij, 2013, Nelson et al., 2013, Eleftherianos and Castillo, 2012, Igboin et al., 2012, Meinander et al., 2012, Guntermann and Foley, 2011, Sabin et al., 2010, Buchon et al., 2009, Costa et al., 2009, Zsindely et al., 2009, Lhocine et al., 2008, Kuranaga and Miura, 2007, Valanne et al., 2007, Akira et al., 2006, Kambris et al., 2006, McGettigan et al., 2005, Zhou et al., 2005, Brennan and Anderson, 2004, Govind and Nehm, 2004, Leclerc and Reichhart, 2004, Lawen, 2003, Zhou et al., 2003, Gorski and Marra, 2002, Janssens and Beyaert, 2002, Leulier et al., 2002, Naitza et al., 2002, Horng and Medzhitov, 2001, Silverman and Maniatis, 2001, Hu, 2000.8.10, Hu and Yang, 2000, Lemaitre, 2000.12.20, Meier et al., 2000)

dFadd

(Capo et al., 2017, Bond and Foley, 2009, Buchon et al., 2009, Tang et al., 2006, Huh et al., 2004, Gorski and Marra, 2002, Richardson and Kumar, 2002)

dfadd

(Verma and Tapadia, 2015, Chinchore et al., 2012, Avadhanula et al., 2009, Leulier et al., 2006)

fadd

(Morris et al., 2016, Berkey et al., 2009)

Name Synonyms

BG4

Fas-associated death domain

(Fukuyama et al., 2013, Igboin et al., 2012)

Fas-associated death domain ortholog

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (127)