FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

extrinsic apoptotic signaling pathway

ID (Ontology)

GO:0097191 (Gene Ontology)

Definition

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.[ PubMed:17340152 ]

Also Known As

"extrinsic apoptotic pathway" ; "extrinsic apoptotic signalling pathway"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
extrinsic apoptotic signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| extrinsic apoptotic signaling pathway

Spanning Tree (Parents/Children)

apoptotic process
 |__apoptotic signaling pathway______________
signal transduction                          |
 |__cell surface receptor signaling pathway__|
 |__apoptotic signaling pathway______________|
                                             extrinsic apoptotic signaling pathway  4 rec.
                                              |__B cell receptor apoptotic signaling pathway
                                              |__death-inducing signaling complex assembly
                                              |   |__regulation of death-inducing signaling complex assembly(+)
                                              |   |__TRAIL death-inducing signaling complex assembly
                                              |__extrinsic apoptotic signaling pathway in absence of ligand
                                              |   |__regulation of extrinsic apoptotic signaling pathway in absence of ligand(+)
                                              |__extrinsic apoptotic signaling pathway via death domain receptors 3 rec.
                                              |   |__regulation of extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.
                                              |   |__TRAIL-activated apoptotic signaling pathway(+)
                                              |__fibroblast growth factor receptor apoptotic signaling pathway
                                              |__regulation of extrinsic apoptotic signaling pathway 3 rec.
                                                  |__negative regulation of extrinsic apoptotic signaling pathway(+) 2 rec.
                                                  |__positive regulation of extrinsic apoptotic signaling pathway(+)
                                                  |__regulation of extrinsic apoptotic signaling pathway in absence of ligand(+)
                                                  |__regulation of extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	cell surface receptor signaling pathway apoptotic signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"death receptor-mediated apoptosis" NARROW "extrinsic apoptosis" NARROW "extrinsic apoptotic pathway" EXACT "extrinsic apoptotic signaling pathway in presence of ligand" NARROW "extrinsic apoptotic signalling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-5357769 "Caspase activation via extrinsic apoptotic signalling pathway"