FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\bchs
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General Information
Symbol
Dmel\bchs
Species
D. melanogaster
Name
blue cheese
Annotation Symbol
CG14001
Feature Type
protein_coding_gene
FlyBase ID
FBgn0043362
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Beach1, EP2299, DBEACH1, Beached, alfy

Key Links
Genomic Location
Cytogenetic map
26A1-26A1
Sequence location
Recombination map
2-18
RefSeq locus
NT_033779 REGION:5907169..5922776
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables metal ion binding
inferred from electronic annotation with InterPro:IPR000306
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in autophagosome assembly
inferred from mutant phenotype
(Bedont et al., 2021)
involved_in brain development
inferred from mutant phenotype
(Kriston-Vizi et al., 2011)
involved_in chaeta development
inferred from genetic interaction with FLYBASE:Rab11; FB:FBgn0015790
(Khodosh et al., 2006)
involved_in compound eye development
inferred from mutant phenotype
(Khodosh et al., 2006)
involved_in fasciculation of motor neuron axon
inferred from mutant phenotype
(Lim and Kraut, 2009)
involved_in lysosome localization
inferred from mutant phenotype
(Lim and Kraut, 2009)
involved_in microtubule bundle formation
inferred from mutant phenotype
(Lim and Kraut, 2009)
involved_in neuron development
inferred from mutant phenotype
(Simonsen et al., 2007)
involved_in positive regulation of organ growth
inferred from mutant phenotype
(Kriston-Vizi et al., 2011)
involved_in regulation of protein ubiquitination
inferred from mutant phenotype
(Simonsen et al., 2007)
involved_in regulation of synapse organization
inferred from genetic interaction with FLYBASE:Rab11; FB:FBgn0015790
(Khodosh et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Finley et al., 2003)
located_in lysosome
inferred from direct assay
(Lim and Kraut, 2009)
located_in neuromuscular junction
inferred from direct assay
(Khodosh et al., 2006)
located_in presynaptic active zone
inferred from direct assay
(Khodosh et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism. [Date last reviewed: 2018-11-08]
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\bchs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VML2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bchs-RA
FBtr0079144
NM_135124
12155
3489
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
bchs-PA
FBpp0078775
389.8
3489
6.96
Q9VML2
NP_608968
AAF52302
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bchs using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.80

Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
adult head
(Simonsen et al., 2008)
Additional Descriptive Data

qRT-PCR of adult female heads assayed at weekly intervals shows that transcript levels decline significantly by 3 weeks and remain supressed.

(Simonsen et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval muscle system
(Lim and Kraut, 2009)
larval DA1 motor neuron
(Lim and Kraut, 2009)
larval RP2 motor neuron
(Lim and Kraut, 2009)
embryonic stage 12 -- 17
larval longitudinal connective
(Lim and Kraut, 2009)
larval central nervous system
(Lim and Kraut, 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data

bchs protein is expressed in the embryonic CNS from stage 12 on. It is observed in the longitudinal connectives and in a subset of neuronal cell bodies that lie between the commissures including the aCC and RP2 motor neurons. It is also observed at low levels throughout the CNS, in muscles, and in some other tissues.

(Lim and Kraut, 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Finley et al., 2003)
located_in lysosome
inferred from direct assay
(Lim and Kraut, 2009)
located_in neuromuscular junction
inferred from direct assay
(Khodosh et al., 2006)
located_in presynaptic active zone
inferred from direct assay
(Khodosh et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bchs in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 38 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bchs
Transgenic constructs containing regulatory region of bchs
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2L)Exel7024)
Sterility
Allele
female fertile
fertile
male fertile
Other Phenotypes
Allele
abnormal immune response | adult stage | recessive
abnormal neuroanatomy, with Scer\GAL4da.G32
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage (with bchs3)
abnormal neuroanatomy | adult stage (with bchs6)
abnormal neuroanatomy | adult stage (with Df(2L)cl7)
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | larval stage (with Df(2L)cl7)
abnormal neuroanatomy | third instar larval stage (with Df(2L)cl7)
decreased cell number | larval stage, with Scer\GAL4eve.PU
decreased cell number | larval stage (with Df(2L)cl7)
decreased cell number | third instar larval stage (with Df(2L)cl7)
short lived
short lived (with Df(2L)cl7)
short lived | male (with bchs3)
short lived | male (with bchs5)
short lived | male (with Df(2L)cl7)
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4sca-537.4
wild-type
Phenotype manifest in
Allele
adult abdomen & microchaeta, with Scer\GAL4sca-537.4
adult central nervous system
adult central nervous system (with Df(2L)cl7)
anterior fascicle & synapse, with Scer\GAL4elav-C155
autophagosome | decreased number | third instar larval stage (with Df(2L)cl7)
autophagosome | larval stage, with bchs17M/Df(2L)cl7, Scer\GAL4eve.PU
autophagosome | larval stage, with Df(2L)cl7/bchs58M, Scer\GAL4eve.PU
autophagosome | larval stage (with Df(2L)cl7)
autophagosome | larval stage (with Df(2L)cl7), with Scer\GAL4eve.PU, bchsUAS.1.GFP
brain (with Df(2L)cl7)
deutocerebrum (with Df(2L)cl7)
dorsocentral bristle, with Scer\GAL4sca-537.4
ellipsoid body (with Df(2L)cl7)
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye disc, with Scer\GAL4da.G32
fan-shaped body (with Df(2L)cl7)
glial cell, with Scer\GAL4da.G32
gnathal ganglion (with Df(2L)cl7)
growth cone, with Scer\GAL4GMR.PF
growth cone & eye photoreceptor cell, with Scer\GAL4GMR.PF
inclusion body | adult stage (with bchs3)
inclusion body | adult stage (with bchs6)
lamina (with Df(2L)cl7)
larval brain | third instar larval stage, with Scer\GAL4elav-C155
larval brain | third instar larval stage (with Df(2L)cl7)
larval DA1 motor neuron | decreased number | third instar larval stage (with Df(2L)cl7)
larval intersegmental nerve, with Scer\GAL4elav-C155
larval neuron | larval stage (with Df(2L)cl7)
larval RP2 motor neuron | decreased number | third instar larval stage (with Df(2L)cl7)
larval RP2 motor neuron | larval stage, with Scer\GAL4eve.PU
larval RP2 motor neuron | larval stage (with Df(2L)cl7)
medulla (with Df(2L)cl7)
neurite | larval stage (with Df(2L)cl7)
neuron & eye photoreceptor cell, with Scer\GAL4GMR.PF
neuron | adult stage (with bchs3)
neuron | adult stage (with bchs6)
ommatidium, with Scer\GAL4GMR.PF
ommatidium (with Df(2L)cl7)
protocerebrum (with Df(2L)cl7)
retina (with Df(2L)cl7)
rhabdomere (with Df(2L)cl7)
scutellar bristle, with Scer\GAL4sca-537.4
vacuole | adult stage (with bchs3)
vacuole | adult stage (with bchs6)
vesicle | larval stage (with Df(2L)cl7)
wing, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (26)
Hsap\WDFY3
14 of 14
Yes
Yes
2  
Hsap\WDFY4
7 of 14
No
Yes
Hsap\LYST
3 of 14
No
No
Hsap\NSMAF
3 of 14
No
Yes
Hsap\WDR81
3 of 14
No
No
Hsap\NBEA
2 of 14
No
No
Hsap\NBEAL1
2 of 14
No
No
Hsap\NBEAL2
2 of 14
No
No
Hsap\ANKFY1
1 of 14
No
No
Hsap\DAW1
1 of 14
No
No
Hsap\EEA1
1 of 14
No
No
Hsap\FBXW11
1 of 14
No
No
1  
Hsap\FGD6
1 of 14
No
No
Hsap\LRBA
1 of 14
No
No
Hsap\MTMR3
1 of 14
No
No
Hsap\MTMR4
1 of 14
No
No
2  
Hsap\PLEKHF1
1 of 14
No
No
Hsap\PLEKHF2
1 of 14
No
No
Hsap\RUFY1
1 of 14
No
No
Hsap\RUFY2
1 of 14
No
No
1  
Hsap\SNRNP40
1 of 14
No
No
Hsap\TEP1
1 of 14
No
No
Hsap\ZFYVE1
1 of 14
No
No
2  
Hsap\ZFYVE9
1 of 14
No
No
Hsap\ZFYVE16
1 of 14
No
No
Hsap\ZFYVE28
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Wdfy3
13 of 14
Yes
Yes
Rnor\Wdfy4
8 of 14
No
Yes
Rnor\Nsmaf
3 of 14
No
Yes
Rnor\Nbeal1
2 of 14
No
No
Rnor\Nbeal2
2 of 14
No
No
Rnor\Wdr81
2 of 14
No
No
Rnor\Ankfy1
1 of 14
No
No
Rnor\Daw1
1 of 14
No
No
Rnor\Eea1
1 of 14
No
No
Rnor\Lrba
1 of 14
No
No
Rnor\Lyst
1 of 14
No
No
Rnor\Mtmr3
1 of 14
No
No
Rnor\Mtmr4
1 of 14
No
No
Rnor\Rufy1
1 of 14
No
No
Rnor\Rufy2
1 of 14
No
No
Rnor\Snrnp40
1 of 14
No
No
Rnor\Zfyve1
1 of 14
No
No
Rnor\Zfyve28
1 of 14
No
No
Mus musculus (laboratory mouse) (20)
Mmus\Wdfy3
14 of 14
Yes
Yes
Mmus\Wdfy4
7 of 14
No
Yes
Mmus\Lyst
3 of 14
No
No
Mmus\Nsmaf
3 of 14
No
Yes
Mmus\Lrba
2 of 14
No
No
Mmus\Nbeal2
2 of 14
No
No
Mmus\Wdr81
2 of 14
No
No
Mmus\Ankfy1
1 of 14
No
No
Mmus\Daw1
1 of 14
No
No
Mmus\Eea1
1 of 14
No
No
Mmus\Mtmr3
1 of 14
No
No
Mmus\Mtmr4
1 of 14
No
No
Mmus\Nbeal1
1 of 14
No
No
Mmus\Nbea
1 of 14
No
No
1  
Mmus\Rrp9
1 of 14
No
No
Mmus\Rufy1
1 of 14
No
No
Mmus\Rufy2
1 of 14
No
No
Mmus\Snrnp40
1 of 14
No
No
Mmus\Zfyve1
1 of 14
No
No
Mmus\Zfyve28
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\wdfy3
11 of 13
Yes
Yes
Xtro\wdfy4
5 of 13
No
Yes
Xtro\nbeal1
2 of 13
No
No
Xtro\cdrt1
1 of 13
No
Yes
Xtro\daw1
1 of 13
No
No
Xtro\LOC100493455
1 of 13
No
No
Xtro\lrba
1 of 13
No
No
Xtro\lyst
1 of 13
No
No
Xtro\mtmr4
1 of 13
No
No
Xtro\nbeal2
1 of 13
No
No
Xtro\nsmaf
1 of 13
No
Yes
Xtro\nwd1
1 of 13
No
No
Xtro\plekhf1
1 of 13
No
No
Xtro\plekhf2
1 of 13
No
No
Xtro\plrg1
1 of 13
No
No
Xtro\rack1
1 of 13
No
No
Xtro\snrnp40
1 of 13
No
No
Xtro\tep1
1 of 13
No
No
Xtro\tmem132e
1 of 13
No
No
Xtro\trpv3
1 of 13
No
No
Xtro\unkl
1 of 13
No
No
Xtro\wdr5
1 of 13
No
No
Xtro\wdr81
1 of 13
No
No
Xtro\zfyve1
1 of 13
No
Yes
Xtro\zfyve28
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\wdfy3
13 of 14
Yes
Yes
Drer\nsmaf
3 of 14
No
Yes
Drer\lyst
2 of 14
No
No
Drer\nbeal1
2 of 14
No
No
Drer\nbeal2
2 of 14
No
No
Drer\wdfy4
2 of 14
No
Yes
Drer\wdr81
2 of 14
No
No
Drer\ankfy1
1 of 14
No
No
Drer\daw1
1 of 14
No
No
Drer\eea1
1 of 14
No
No
Drer\im:7138144
1 of 14
No
No
Drer\lrba
1 of 14
No
No
Drer\mtmr3
1 of 14
No
No
Drer\nbeaa
1 of 14
No
No
Drer\nbeab
1 of 14
No
No
Drer\rrp9
1 of 14
No
No
Drer\rufy1
1 of 14
No
No
Drer\rufy2
1 of 14
No
No
Drer\si:ch211-11n16.2
1 of 14
No
No
Drer\snrnp40
1 of 14
No
No
Drer\wdr83
1 of 14
No
No
Drer\zfyve28
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\wdfy-3
12 of 14
Yes
Yes
Cele\lyst-1
3 of 14
No
Yes
Cele\sorf-2
3 of 14
No
No
Cele\sel-2
2 of 14
No
No
Cele\eea-1
1 of 14
No
No
Cele\lin-23
1 of 14
No
No
Cele\lst-2
1 of 14
No
No
Cele\plrg-1
1 of 14
No
No
Cele\sel-10
1 of 14
No
No
Cele\ZK632.12
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (20)
Agam\AgaP_AGAP012452
5 of 12
Yes
Yes
Agam\AgaP_AGAP000429
3 of 12
No
Yes
Agam\AgaP_AGAP004144
3 of 12
No
No
Agam\AgaP_AGAP012480
3 of 12
No
Yes
Agam\AgaP_AGAP003389
2 of 12
No
No
Agam\AgaP_AGAP007731
2 of 12
No
No
Agam\AgaP_AGAP012479
2 of 12
No
Yes
Agam\AgaP_AGAP012488
2 of 12
No
Yes
Agam\AgaP_AGAP000017
1 of 12
No
No
Agam\AgaP_AGAP000407
1 of 12
No
No
Agam\AgaP_AGAP001604
1 of 12
No
No
Agam\AgaP_AGAP002036
1 of 12
No
Yes
Agam\AgaP_AGAP003395
1 of 12
No
No
Agam\AgaP_AGAP003431
1 of 12
No
No
Agam\AgaP_AGAP003678
1 of 12
No
No
Agam\AgaP_AGAP005359
1 of 12
No
No
Agam\AgaP_AGAP005631
1 of 12
No
No
Agam\AgaP_AGAP008129
1 of 12
No
No
Agam\AgaP_AGAP010173
1 of 12
No
No
Agam\AgaP_AGAP010307
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\AT4G02660
11 of 13
Yes
Yes
Atha\SPI
11 of 13
Yes
Yes
Atha\AT1G58230
2 of 13
No
No
Atha\AT2G45540
2 of 13
No
No
Atha\AT3G60920
2 of 13
No
No
Atha\AT5G18525
2 of 13
No
No
Atha\AT1G11160
1 of 13
No
No
Atha\AT1G20110
1 of 13
No
No
Atha\AT1G61690
1 of 13
No
Yes
Atha\AT4G34380
1 of 13
No
Yes
Atha\AT5G49430
1 of 13
No
No
Atha\FBX2
1 of 13
No
No
Atha\WDR5a
1 of 13
No
No
Atha\YAO
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\BPH1
8 of 13
Yes
Yes
Scer\MET30
1 of 13
No
No
Scer\PRP46
1 of 13
No
No
Scer\TAF5
1 of 13
No
No
Scer\VPS27
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\lvs1
9 of 12
Yes
Yes
Spom\sst4
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:bchs. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
CG43367
3 of 13
mv
3 of 13
Wdr81
3 of 13
ago
1 of 13
CG3632
1 of 13
CG4935
1 of 13
CG6051
1 of 13
CG31064
1 of 13
Rack1
1 of 13
Rbpn-5
1 of 13
rg
1 of 13
rush
1 of 13
slmb
1 of 13
Tango4
1 of 13
U3-55K
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
WDFY3; WD repeat and FYVE domain containing 3
14 of 14
WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 3; WDFY3
 
WDFY4; WDFY family member 4
7 of 14
613316
      LYST; lysosomal trafficking regulator
      3 of 14
      606897
      NSMAF; neutral sphingomyelinase activation associated factor
      3 of 14
      603043
          WDR81; WD repeat domain 81
          3 of 14
          614218
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          bchs
          enhanceable
          Atg1
          (Simonsen et al., 2007)
          bchs
          suppressible
          Atg2
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Atg6
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Atg7
          (Sim et al., 2019)
          bchs
          suppressible
          Atg7
          (Sim et al., 2019)
          bchs
          suppressible
          Atg8a
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Atg18a
          (Simonsen et al., 2007)
          bchs
          enhanceable
          btv
          (Simonsen et al., 2007)
          bchs
          enhanceable
          ca
          (Simonsen et al., 2007)
          bchs
          enhanceable
          car
          (Simonsen et al., 2007)
          bchs
          enhanceable
          CDase
          (Hebbar et al., 2015)
          bchs
          suppressible
          CDase
          (Hebbar et al., 2015)
          bchs
          suppressible
          Diap1
          (Müller et al., 2005)
          bchs
          enhanceable
          Dlic
          (Simonsen et al., 2007)
          bchs
          enhanceable
          dor
          (Simonsen et al., 2007)
          bchs
          enhanceable
          eff
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Gga
          (Luan et al., 2012, Eissenberg et al., 2011)
          bchs
          enhanceable
          hook
          (Simonsen et al., 2007)
          bchs
          enhanceable
          lace
          (Hebbar et al., 2015)
          bchs
          suppressible
          lace
          (Hebbar et al., 2015)
          bchs
          enhanceable
          Lerp
          (Hasanagic et al., 2015)
          bchs
          enhanceable
          lwr
          (Simonsen et al., 2007)
          bchs
          suppressible
          nSMase
          (Hebbar et al., 2015)
          bchs
          enhanceable
          or
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Rab11
          (Simonsen et al., 2007, Khodosh et al., 2006)
          bchs
          enhanceable
          Rab32
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Rop
          (Simonsen et al., 2007)
          bchs
          enhanceable
          spin
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Sumo
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Syx1A
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Syx13
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Uba1
          (Simonsen et al., 2007)
          bchs
          enhanceable
          Usp7
          (Simonsen et al., 2007)
          bchs
          enhanceable
          αTub84B
          (Simonsen et al., 2007)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Atg7
          enhanceable
          bchs
          (Sim et al., 2019)
          Cdc42
          enhanceable
          bchs
          (Raymond et al., 2004)
          Dcp-1
          enhanceable
          bchs
          (Kim et al., 2010)
          Dcp-1
          suppressible
          bchs
          (Kim et al., 2010)
          H
          enhanceable
          bchs
          (Müller et al., 2005)
          Ppt1
          enhanceable
          bchs
          (Buff et al., 2007)
          Rab11
          suppressible
          bchs
          (Khodosh et al., 2006)
          Rac1
          enhanceable
          bchs
          (Raymond et al., 2004)
          RacGAP84C
          enhanceable
          bchs
          (Raymond et al., 2004)
          Ras85D
          enhanceable
          bchs
          (Raymond et al., 2004)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-18
          Cytogenetic map
          26A1-26A1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          26A1-26A1
          Limits computationally determined from genome sequence between P{lacW}l(2)k06502k06502 and P{EP}bchsEP2299&P{EP}GpdhEP466
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          26A1-26A2
          (determined by in situ hybridisation)
          (Abdelilah-Seyfried et al., 2000)
          Experimentally Determined Recombination Data
          Location

          2-18

          (FlyBase, 2016)

          2-19.2

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (20)
          Genomic Clones (26)
          cDNA Clones (6)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Lim and Kraut, 2009)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  bchs may have some role in determining cellular volume and/or proliferation in the brain.

                  (Kriston-Vizi et al., 2011)

                  Mutants demonstrate a reduced adult life span associated with age-dependent formation of protein aggregates throughout the CNS. Protein inclusions contain insoluble ubiquinated proteins and aggregates of Appl. Brains from older bchs mutants also show extensive neuronal apoptosis.

                  (Finley et al., 2002)

                  Identification: in a screen for genes which when overexpressed cause motorneuron pathfinding and or synaptogenesis errors.

                  (Kraut and Zinn, 2001)

                  Involved in endocytosis/membrane trafficking.

                  (Kraut and Zinn, 2001)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: Beach1 CG9011 CG14001 EP2299

                  (Kraut et al., 2001, Kraut et al., 2001)

                  Source for merge of: Beach1 BcDNA:SD12984

                  (FlyBase, 1996-)
                  Additional comments

                  Source for merge of Beach1 BcDNA:SD12984 was a shared cDNA ( date:030728 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Beach1 bchs

                  (Finley, 2002.3.18)
                  Nomenclature comments
                  Etymology

                  The gene is named 'blue cheese' based on the formation of protein inclusions throughout the CNS in mutants.

                  (Finley et al., 2003)
                  Synonyms and Secondary IDs (21)
                  Reported As
                  Symbol Synonym
                  Alfy
                  (Érdi et al., 2012)
                  BcDNA:SD12984
                  Bchs
                  (Regan et al., 2022, Lu et al., 2021, Gohel et al., 2020, Metwally et al., 2019, Lőrincz et al., 2016, Hasanagic et al., 2015, Liu et al., 2014, Luan et al., 2012, Nezis, 2012, Kim et al., 2010, Martin et al., 2007)
                  Beach1
                  (Raymond et al., 2004)
                  CG14001
                  (National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Metwally et al., 2019, O'Farrell et al., 2017, Érdi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Molnar et al., 2006, Finley et al., 2003)
                  CG9011
                  (Finley et al., 2003)
                  DBEACH1
                  (Kraut et al., 2001, Kraut et al., 2001)
                  EP2299
                  (Abdelilah-Seyfried et al., 2001, Abdelilah-Seyfried et al., 2000)
                  alfy
                  (Saitoh et al., 2015, Filimonenko et al., 2010)
                  bchd
                  bchs
                  (Fanara et al., 2023, Marcogliese et al., 2022, Saha et al., 2022, Cunningham et al., 2020, De et al., 2020, Sorvina et al., 2020, Meltzer et al., 2019, Galluzzi et al., 2017, Lou et al., 2017, O'Farrell et al., 2017, Stessman et al., 2017, Gene Disruption Project members, 2016-, Hebbar et al., 2015, Mulakkal et al., 2014, de Celis et al., 2013.9.11, Esslinger et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nezis, 2012, Bartlett et al., 2011, Eissenberg et al., 2011, Kriston-Vizi et al., 2011, Yuva-Aydemir et al., 2011, Clausen et al., 2010, Filimonenko et al., 2010, Kim et al., 2010, Wasbrough et al., 2010, Wendler et al., 2010, Lim and Kraut, 2009, Kumarasamy et al., 2008, Simonsen et al., 2008, Finley et al., 2007, Simonsen et al., 2007, Molnar et al., 2006)
                  beach
                  (Sim et al., 2019)
                  Name Synonyms
                  Beach1
                  (Finley, 2002.3.18, Kraut, 2002.3.6)
                  Beached
                  (Kraut and Zinn, 2002, Kraut and Zinn, 2001)
                  Beached 1
                  (Kraut, 2002.3.6)
                  Beached1
                  (Raymond et al., 2004)
                  Blue Cheese
                  (O'Farrell et al., 2017, Lőrincz et al., 2016, Nezis, 2012, Eissenberg et al., 2011)
                  Blue cheese
                  (Balakrishnan et al., 2015, Hasanagic et al., 2015, Liu et al., 2014, Mulakkal et al., 2014, Érdi et al., 2012, Nezis, 2012, Eissenberg et al., 2011, Kim et al., 2010, Buff et al., 2007)
                  beached
                  (Wright et al., 2005)
                  blue cheese
                  (Shafer, 2025, Bedont et al., 2021, Hebbar et al., 2015, Mulakkal et al., 2014, Nezis, 2012, Clausen et al., 2010, Filimonenko et al., 2010, Hortsch et al., 2010, Lim and Kraut, 2009, Kumarasamy et al., 2008, Simonsen et al., 2008, Finley et al., 2007, Korey et al., 2007, Simonsen et al., 2007, Khodosh et al., 2006, Beckstead et al., 2005, Finley and Kraut, 2004.4.16)
                  dbeach1
                  (Khodosh et al., 2003)
                  lyst
                  (Sorvina et al., 2020)
                  Secondary FlyBase IDs
                  • FBgn0031748
                  • FBgn0031750
                  • FBgn0062881
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (114)