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General Information
Symbol
Dmel\bchs58
Species
D. melanogaster
Name
FlyBase ID
FBal0193781
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(2L)2299, EP(2)2299
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

The reported Ile to Stop amino acid change (ATC to TAA, TAG or TGA) requires nucleotide changes at all three positions of the codon. The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change. It has been annotated as a TAA stop codon, though the identity of the stop codon was not reported.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of 3bp and a deletion of 17bp within bchs. This is predicted to result in a frame shift and subsequent stop codon. The P{EP}EP2299 insertion is also present on the chromosome.

The progenitor P{EP}EP2299 insertion is still present on the chromosome.

Amino acid replacement: I1830term.

Insertion components
P{EP}EP2299
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

bchs58/Df(2L)cl7 transheterozygous larvae exhibit a decrease in the number of RP2 motor neurons, compared to controls.

AGO2414 homozygotes show a significant decrease in viral load in the head upon infection with ZIKV, as compared to infected controls.

bchs58/Df(2L)cl7 and bchs58 homozygous mutants display a 15 and 17% reduction in the brain volumes of third instar larvae, respectively.

Expression of bchs58 under the control of Scer\GAL4GMR.PF does not cause the small eye or growth cone phenotypes seen when wild-type bchs is overexpressed.

bchs58 mutants show no defects in the larval visual system or embryonic central nervous system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

bchs58/bchs58 is a suppressor of microchaeta phenotype of Rab1193Bi

bchs58/bchs[+] is a suppressor | partially of microchaeta phenotype of Rab1193Bi

Additional Comments
Genetic Interactions
Statement
Reference

The microchaeta loss of Rab1193Bi flies is significantly suppressed by bchs58/+ and is completely suppressed by bchs58/bchs58.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)