protein kinase A anchor protein - required for correct retinal pattern formation through its interactions with Egfr and Notch pathways - mutants of the autism candidate gene exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, impaired adult social behavior and activity patterns
Gene model reviewed during 5.54
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
None of the polypeptides share 100% sequence identity.
Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rg using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\rg in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Akap550 CG6775
One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG44835 (FBgn0266098), CG15465 (FBgn0029746).
Annotations CG6775 and CG15464 merged as CG44835 in release 5.52 of the genome annotation. Merge based on RNA-Seq junction and expression data.
Release 2 annotation CG15466 (which was eliminated in release 3 of the genome annotation) has been merged with CG6775 (which corresponds to rg) in release 5.1 of the genome annotation.
may be allelic to lzl: lozenge-like
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Annotation CG15466 was eliminated in release 3 of the genome annotation, October 2002.
Cloning and sequencing of rg cDNA, the differential expression of the protein during embryogenesis and the mapping of the binding site are studied.
The abnormal rg phenotype is due to a developmental defect: late occurring defects. Adult eye is rough with variable facet shape, variable number of rhabdomeres per ommatidium, eye disc pattern appears normal.