FlyBase Gene Report: Dmel\Cth

General Information

Symbol

Dmel\Cth

Species

D. melanogaster

Name

Cystathionine gamma-lyase

Annotation Symbol

CG5345

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000566

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Cystathionine gamma-lyase (Cth) encodes a cytosolic pyridoxal 5'-phosphate-dependent enzyme that catalyzes the hydrolysis of L,L-cystathionine into L-cysteine, ammonia and 2-oxobutanoate, the last step of L-cysteine biosynthesis (also known as the transsulfuration pathway). Cth is also involved in the production of hydrogen sulfide. [Date last reviewed: 2026-02-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

Eip55E, CSE, Eip40, cystathionine γ-lyase

Key Links

Genomic Location

Cytogenetic map

55E2-55E2

Sequence location

2R:18,627,918..18,629,395 [+]

Recombination map

2-86

RefSeq locus

NT_033778 REGION:18627918..18629395

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cystathionine gamma-lyase activity

inferred from sequence or structural similarity with UniProtKB:P32929

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000211591

(GO Reference Genome Project, 2011-)

enables pyridoxal phosphate binding

inferred from electronic annotation with InterPro:IPR000277

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in hydrogen sulfide biosynthetic process

inferred from mutant phenotype

(Shilova et al., 2025)

involved_in transsulfuration

inferred from mutant phenotype

(Kabil et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sulfur amino acid metabolic process

non-traceable author statement

(Andres et al., 1993)

involved_in transsulfuration

inferred from electronic annotation with InterPro:IPR000277

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000211590

(GO Reference Genome Project, 2011-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CARBON-SULFUR LYASES

Pathway (FlyBase)

L-CYSTEINE BIOSYNTHESIS

HYDROGEN SULFIDE BIOSYNTHESIS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cystathionine gamma-lyase activity
RHEA 14005:

Summaries

Gene Snapshot

Gene Group (FlyBase)

CARBON-SULFUR LYASES -: Carbon-Sulfur lyases catalyze the the cleavage of carbon-sulfur bond with the release of hydrogen sulfide or substituted H2S by means other than hydrolysis or oxidation. (Adapted from FBrf0238856).

Pathway (FlyBase)

L-CYSTEINE BIOSYNTHESIS -: L-cysteine biosynthesis, also known as the transsulfuration pathway, occurs in the cytosol and converts L-homocysteine, a metabolite derived from L-methionine metabolism, to L-cysteine. Besides its role in protein biosynthesis, L-cysteine is also a precursor for glutathione, taurine, hypotaurine and hydrogen sulfide (H2S) production. It is involved in the synthesis of Mo-molybdopterin cofactor, Iron-Sulfur (Fe-S) cluster assembly and coenzyme A. (Adapted from PMID:31460700 and PMID: 29530337.)
HYDROGEN SULFIDE BIOSYNTHESIS -: Hydrogen sulfide (H2S) is a gasotransmitter synthesized in the cytosol from L-cysteine and/or homocysteine via two enzymes of the transsulfuration pathway, cystathionine β-synthase Cbs and γ-cystathionase Cth. (Adapted from PMID:21315854 and FBrf0262727.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Eip55BD: Ecdysteroid-inducible polypeptide encoded in 55BD

The structural gene for a 40 kilodalton polypeptide (EIP40) whose concentration in Kc cells increases detectably beginning 30-60 min following administration of ecdysteroid hormone and reaching a maximum after 4-6 hr (Savakis, Demetri, and Cherbas, 1980, Cell 22: 665-74).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cth for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7JXZ2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.44

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cth-RA

FBtr0086710

NM_137508

1362

393

Cth-RB

FBtr0345422

NM_001299649

1478

393

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cth-PA

FBpp0085889

43.0

393

7.72

FBpp0311547

43.0

393

7.72

Q7JXZ2

NP_001286578

AHN56373

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

393 aa isoforms: Cth-PA, Cth-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cth using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Eip55E_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.35

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval lymph gland

(Andres and Cherbas, 1992)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

amnioserosa

(Fisher et al., 2012)

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

larval stage

embryonic/larval fat body

(Andres and Cherbas, 1992)

third instar larval stage

embryonic/larval salivary gland

(Andres and Cherbas, 1992)

Additional Descriptive Data

The Cth transcript is present at a high and constant level through most embryonic and larval stages. It is present at a low level through pupation and is higher again in adults. Cth transcripts are present in all tissues and are abundant in fat body, salivary glands, and lymph glands in third instar larvae. Transcript levels in the lymph glands increase just prior to metamorphosis.

(Andres and Cherbas, 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cth in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cth

View exonic expression by tissue for Dmel\Cth

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000566

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37143/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000566

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000566

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000566

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0000566

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cth

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cth

Transgenic constructs containing regulatory region of Cth

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)Ex212

(Murthy et al., 2005)

Df(2R)Exel7157

(Ryder, 2004.4.26)

Df(2R)Sec6¹⁷⁵

(Beronja et al., 2005)

Gene partially disrupted in

Df(2R)Sec6^Ex15

(Murthy et al., 2005)

Df(2R)Sec6^Ex228

(Murthy et al., 2005)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Cth^GD1283

viable

Cth^EP2021

Sterility

Allele

fertile

Cth^EP2021

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\CTH

14 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Cth

14 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Cth

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\cth

8 of 13

Yes

Xtro\cmahp

1 of 13

Yes

Xtro\jup

1 of 13

Danio rerio (Zebrafish) (2)

Drer\cth

14 of 14

Yes

Drer\cthl

14 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\cth-2

14 of 14

Yes

Cele\cth-1

13 of 14

Yes

Cele\cbl-1

5 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP011172

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (4)

Atha\CBL

9 of 13

Yes

Atha\AT1G33320

5 of 13

Yes

Atha\MTO1

5 of 13

Yes

Atha\MGL

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\CYS3

13 of 13

Yes

Scer\STR3

5 of 13

Yes

Scer\YHR112C

3 of 13

Yes

Scer\IRC7

2 of 13

Yes

Scer\MET17

2 of 13

Yes

Scer\STR2

2 of 13

Yes

Scer\YLL058W

2 of 13

Yes

Scer\YML082W

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\SPCC11E10.01

7 of 12

Yes

Spom\SPAC23A1.14c

3 of 12

Yes

Spom\SPBC15D4.09c

2 of 12

Yes

Spom\SPBC428.11

2 of 12

Yes

Escherichia coli (enterobacterium) (4)

Ecol\metB

10 of 11

Yes

Ecol\metC

2 of 11

Yes

Ecol\arnB

1 of 11

Yes

Ecol\yhfS

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cth. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Cth¹

model of homocystinuria

CEA

(Zatsepina et al., 2022)

CEC with Cbs⁵

(Zatsepina et al., 2022)

CEC with Cbs⁸

(Zatsepina et al., 2022)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CTH; cystathionine gamma-lyase

model of cystathioninuria

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Cth^KG02526

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cTa

(Trinh et al., 2008)

Cth^HMS03027

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Huber et al., 2023)

Cth^UAS.cSb

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Snijder et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CTH; cystathionine gamma-lyase

14 of 14

607657

CYSTATHIONINURIA

cystathioninuria

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cth - CG34133

experimental knowledge based

(Guruharsha et al., 2011)

Cth - Prx6c

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62817

DroID - A comprehensive database of gene and protein interactions.

FBgn0000566

MIST (genetic) - An integrated Molecular Interaction Database

37143

MIST (protein-protein) - An integrated Molecular Interaction Database

37143

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

L-CYSTEINE BIOSYNTHESIS
HYDROGEN SULFIDE BIOSYNTHESIS

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-86

Cytogenetic map

55E2-55E2

Sequence location

2R:18,627,918..18,629,395 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55E2-55E2

Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)03709⁰³⁷⁰⁹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

55B-55E

(Rebers, 1998.9.25)

Experimentally Determined Recombination Data

Location

2-86

(FlyBase, 2016)

2-91.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

13752

y¹ w^67c23; P{SUPor-P}Cth^KG02526

68128

y¹ sc^* v¹ sev²¹; P{TOE.GS00525}attP40

79405

y¹ sc^* v¹ sev²¹; P{TKO.GS00940}attP40

41876

y¹ sc^* v¹ sev²¹; P{TRiP.GL01308}attP40

36766

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03027}attP2/TM3, Sb¹

NIG-Fly

5345R-3

P{NIG.5345R}3

2RG-1394

y² VhaAC39-1^cho-1 v¹; P{U6-Cth.NIG.sgRNA}attP40/CyO

HMS03027

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03027}attP2/TM3, Sb¹

VDRC

v103779

P{KK102650}VIE-260B

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (93)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD22255

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000566

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000566

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

Ecdysteroid-regulated gene.

(Andres et al., 1993)

Eip55E is ecdysone inducible only in the lymph gland and only at the premetamorphic peak.

(Andres and Cherbas, 1992)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cth Eip55E

(FlyBase, 2017-)

Nomenclature comments

Etymology

Named 'Cth' based on the vertebrate ortholog.

(FlyBase, 2017-)

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG5345

(National Institute of Genetics Fly Stocks, 2022-, Zatsepina et al., 2020, Shaposhnikov et al., 2018, Parkhitko et al., 2016, Mathew et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

CSE

(Xu et al., 2026, Shaposhnikov et al., 2023, Shaposhnikov et al., 2022, Zatsepina et al., 2022, Zatsepina et al., 2020, Zivanovic et al., 2019, Shaposhnikov et al., 2018, Snijder et al., 2016)

Cth

(Ham et al., 2023, Cahill et al., 2021)

EIP40

(van Steensel et al., 2001)

Eip40

(Rebers, 1999, Rebers, 1998.9.25, Andres et al., 1993, Cherbas, 1993, Andres and Cherbas, 1992, Andres and Thummel, 1992, Thummel, 1990)

Eip55BD

LD22255

(Sun et al., 2007)

cse

(Shilova et al., 2025, Shilova et al., 2020)

Name Synonyms

Cystathionine gamma-lyase

Ecdysone-induced polypeptide 40kD

Ecdysone-induced protein 40kD

Ecdysone-induced protein 55E

Eip55E

cystathionine γ-lyase

(Shaposhnikov et al., 2021, Zatsepina et al., 2020)

cystathionine-γ-lyase

(Shaposhnikov et al., 2022)

ecdysone induced protein 55E

(Kim et al., 2010)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37143

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7JXZ2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7JXZ2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000566

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37143/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000566

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000566

FlyMine - An integrated database for Drosophila genomics

FBgn0000566

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5345

MARRVEL_MODEL - MARRVEL (model organism gene)

37143

Linkouts

BioGRID - A database of protein and genetic interactions.

62817

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000566

DroID - A comprehensive database of gene and protein interactions.

FBgn0000566

DRSC - Results frm RNAi screens

FBgn0000566

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Eip55E_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000566

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000566

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0000566

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000566

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012563

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

37143

MIST (protein-protein) - An integrated Molecular Interaction Database

37143

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

-0.35

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