FB2026_02 , released June 18, 2026
Pathway: HYDROGEN SULFIDE BIOSYNTHESIS
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General Information
Name
HYDROGEN SULFIDE BIOSYNTHESIS
Species
D. melanogaster
Symbol
HTSBIO
FlyBase ID
FBgg0002228
Date last reviewed
2026-05-18
Number of members
2
Description
Description
Hydrogen sulfide (H2S) is a gasotransmitter synthesized in the cytosol from L-cysteine and/or homocysteine via two enzymes of the transsulfuration pathway, cystathionine β-synthase Cbs and γ-cystathionase Cth. (Adapted from PMID:21315854 and FBrf0262727.)
Notes

In mammals, hydrogen sulfide can also be produced by the desulfuration of 3-mercaptopyruvate (a by-product of L-cysteine catabolism) by 3-mercaptopyruvate sulfurtransferase (MPST); however, this pathway is likely absent in D. melanogaster since it lacks an ortholog of MPST.

Source Material
The HYDROGEN SULFIDE BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Shilova et al., 2025 .
Key Gene Ontology (GO) terms
Biological Process
hydrogen sulfide biosynthetic process
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
NEUROTRANSMITTER METABOLISM
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
Synonyms and Secondary IDs
Synonym(s)
HTSBIO
HYDROGEN SULFIDE BIOSYNTHESIS
Secondary FlyBase ID(s)
References (2)