FlyBase Allele Report: Hsap\TARDBP[M337V.UAS.Tag:MYC]

General Information

Symbol

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

Species

H. sapiens

Name

FlyBase ID

FBal0261050

Feature type

allele

Associated gene

Hsap\TARDBP

Associated Insertion(s)

Carried in Construct

P{UAS-TDP-43.M337V.Myc}

Also Known As

TDP-43^M337V, UAS-TDP-43 M337V, UAS-hTDP-43^M337V, UAS-TDP-43-M337V

Key Links

Transgenic product class

missense_variant

(Ritson et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Ritson et al., 2010)

Mutagen

in vitro construct

(Ritson et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-TDP-43.M337V.Myc}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\TARDBP coding sequences which carry the ALS disease-causing M337V mutation. The protein is tagged with Tag:MYC.

(Ritson et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\TARDBP

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis type 10

CEC

(Khalil et al., 2022)

CEA

(Glineburg et al., 2024, Hwang et al., 2024, Huber et al., 2023, Kankel et al., 2020, Zhang et al., 2020, Markmiller et al., 2018, Periz et al., 2015, He et al., 2014)

model of amyotrophic lateral sclerosis

CEA

(Uechi et al., 2018, Crippa et al., 2016)

model of neurodegenerative disease

CEA

(Ritson et al., 2010)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis type 10

is ameliorated by Fs(2)Ket^EY06666

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^GL01273

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^HMS02872

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^JF02721

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^KK100714

(Khalil et al., 2022)

is ameliorated by Fs(2)Ket^{UAS.cKa.Tag:V5}

(Khalil et al., 2022)

is ameliorated by cdm^UAS.cGa

(Khalil et al., 2022)

is exacerbated by βTub85D^HMC06040

(Huber et al., 2023)

is exacerbated by CG5382^HMC05570

(Huber et al., 2023)

is ameliorated by Cth^HMS03027

(Huber et al., 2023)

is ameliorated by Had1^KK108568

(Huber et al., 2023)

is ameliorated by Hpr1^GD9706

(Huber et al., 2023)

is ameliorated by Klp61F^HMS00552

(Huber et al., 2023)

is ameliorated by MED23^HMS01135

(Huber et al., 2023)

is ameliorated by Ndc1^HMC06378

(Huber et al., 2023)

is ameliorated by Nmnat^JF03337

(Huber et al., 2023)

is ameliorated by PNKP^HMS01919

(Huber et al., 2023)

is ameliorated by Pex19^HMC03104

(Huber et al., 2023)

is ameliorated by Polr2K^HMS05951

(Huber et al., 2023)

is ameliorated by Qsox2^JF02857

(Huber et al., 2023)

is ameliorated by STUB1^HMS00889

(Huber et al., 2023)

is exacerbated by c12.1^HMS00382

(Huber et al., 2023)

is exacerbated by hyd^HMS00343

(Huber et al., 2023)

is exacerbated by mRNA-cap^HMS00631

(Huber et al., 2023)

is ameliorated by osa^HMS01738

(Huber et al., 2023)

is exacerbated by wapl^HMS05805

(Huber et al., 2023)

is ameliorated by Ube4B^JF02691

(Periz et al., 2015)

is ameliorated by Pka-R2^d02258

(Kankel et al., 2020)

is ameliorated by Ask1^HMS00464

(Kankel et al., 2020)

is ameliorated by Pld^HMS00529

(Kankel et al., 2020)

is ameliorated by Atx-1^f01201

(Kankel et al., 2020)

is ameliorated by Hsp110^d03562

(Kankel et al., 2020)

is ameliorated by Setx^f05408

(Kankel et al., 2020)

is exacerbated by Strip^e04482

(Kankel et al., 2020)

is exacerbated by dco^d06510

(Kankel et al., 2020)

is exacerbated by glo^f02674

(Kankel et al., 2020)

is ameliorated by heca^d10800

(Kankel et al., 2020)

is ameliorated by orb^d06989

(Kankel et al., 2020)

is ameliorated by pum^d04225

(Kankel et al., 2020)

is exacerbated by sas^d07239

(Kankel et al., 2020)

is ameliorated by d10800^d10800

(Kankel et al., 2020)

is exacerbated by Smox^JF02320

(Zhang et al., 2020)

is ameliorated by Usp7^HMS01187

(Zhang et al., 2020)

is exacerbated by babo^HMS02033

(Zhang et al., 2020)

is ameliorated by Dbct^KO

(Hwang et al., 2024)

is ameliorated by Dbct^TKO.GS01842

(Hwang et al., 2024)

is ameliorated by Rbp6^d08411

(Markmiller et al., 2018)

is ameliorated by Rox8^e04432

(Markmiller et al., 2018)

is ameliorated by Su(var)205^c06825

(Markmiller et al., 2018)

is ameliorated by bel^GL00205

(Markmiller et al., 2018)

is ameliorated by shep^d07053

(Markmiller et al., 2018)

is exacerbated by SFV\nsp3^UAS.mApple

(Glineburg et al., 2024)

model of amyotrophic lateral sclerosis

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

is ameliorated by Rpn11^UAS.cTa

(Uechi et al., 2018)

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Eye degeneration used to model disease.

(Ritson et al., 2010)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Ritson et al., 2010)

TARDBP:p.Met337Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

amyotrophic lateral sclerosis 10 with or without frontotemporal dementia

External database links

ClinVar: TARDBP_5228

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Kim et al., 2018, Crippa et al., 2016)

abnormal eye color | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

abnormal locomotor behavior | adult stage, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

increased cell death, with Scer\GAL4^GMR.PF

(Ritson et al., 2010)

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

some die during pupal stage, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

visible, with Scer\GAL4^GMR.PF

(Kim et al., 2018)

visible | adult stage, with Scer\GAL4^GMR.PF

(Casci et al., 2019, Crippa et al., 2016)

visible | adult stage, with Scer\GAL4^GMR.PU

(Fortuna et al., 2021, Kankel et al., 2020, Zhang et al., 2020)

visible | adult stage, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Casci et al., 2019, Kim et al., 2018, Crippa et al., 2016, Ritson et al., 2010)

eye, with Scer\GAL4^GMR.PU

(Fortuna et al., 2021, Kankel et al., 2020, Zhang et al., 2020)

eye | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

ommatidium, with Scer\GAL4^GMR.PF

(Ritson et al., 2010)

wing, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Detailed Description

Statement

Reference

The expression of Hsap\TARDBP^{M337V.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PU induces eye degeneration.

(Fortuna et al., 2021)

Expressing Hsap\TARDBP^{M337V.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PU leads to eye defects - rough-eye phenotype, eye degeneration and loss of pigmentation .

(Kankel et al., 2020)

Expression of Hsap\TARDBP^{M337V.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PU leads to eye degeneration (thinner neuronal layer in the eyes) in adults.

(Zhang et al., 2020)

Expressing Hsap\TARDBP^{M337V.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PF results in eye degeneration: rough eye with loss of pigmentation.

(Casci et al., 2019)

The expression of Hsap\TARDBP^{M337V.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PF leads to a rough eye phenotype, with depigmentation.

(Kim et al., 2018)

Expression of Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU leads to age-dependent eye degeneration associated with pigmentation loss and formation of necrotic patches. Scer\GAL4^RapGAP1-OK6-driven expression of Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC} results in increased pupal lethality (about half of the flies are pupal lethal and fail to eclose), adults that do manage to eclose all display wing expansion defects and most also loss of climbing ability.

(Uechi et al., 2018)

Expression of Hsap\TARDBP^{M337V.Scer\UAS} under the control of Scer\GAL4^GMR.PF leads to eye degeneration phenotype - partial depigmentation and rough eye surface.

(Crippa et al., 2016)

Expression of Hsap\TARDBP^{M337V.Scer\UAS} in the developing eye under the control of Scer\GAL4^GMR.PF results in a range of degenerative phenotypes, with severity depending on the amount of Hsap\TARDBP^{M337V.Scer\UAS} present.

(Ritson et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Strip[+]/Strip^e04482

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by sas[+]/sas^d07239

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by glo^f02674/glo[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by babo^HMS02033, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Smox^JF02320, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by babo^GD51, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Smox^HMS02203, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has abnormal eye color | progressive phenotype, enhanceable by CG5445^NIG.5445R/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by TER94^R152H.UAS.R, Scer\GAL4^GMR.PF

(Ritson et al., 2010)

NOT Enhanced by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Suppressed by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Setx[+]/Setx^f05408

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by dco[+]/dco^d06510

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsc70Cb[+]/Hsp110^d03562

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ask1^HMS00464, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Pka-R2^d02258/Pka-R2[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Atx-1^f01201/Atx-1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by orb[+]/orb^d06989

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by pum^d04225/pum[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by lilli[+]/lilli^c00800

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Fife^d01275/Fife[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c07023^c07023/c07023[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by corto[+]/corto^c03244

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c01399^c01399/c01399[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c01295[+]/c01295^c01295

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d08551^d08551/d08551[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d00123[+]/d00123^d00123

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by mrva[+]/mrva^d09937

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by or[+]/or^e02236

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by e00530^e00530/e00530[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG5342[+]/CG5342^e01976

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by rdo^e02234/rdo[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d00147^d00147/d00147[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hph^e00985/Hph[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by mus201[+]/mus201^e01238

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Plp^d10223/Plp[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Plp[+]/Plp^d11666

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rbp9[+]/Rbp9^e02166

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG16890[+]/CG16890^e02098

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG11842[+]/CG11842^e02284

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG13334^e02535/CG13334[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d10376[+]/d10376^d10376

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by peo^e02684/CG46338[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by NAT1^e04015/NAT1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by comm3[+]/comm3^e03409

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG10011[+]/CG10011^f01587

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by RpS16[+]/RpS16^f06593

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by e04545^e04545/e04545[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp12-46^e02699/Usp12-46[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sra^c03600/sra[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mis12^f03756/Mis12[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c04797^c04797/c04797[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ptpmeg[+]/Ptpmeg^c06293

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Kpc1^c06744/Kpc1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by nebu[+]/nebu^f03242

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Prp18^c07155/Prp18[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sNPF^c07042/sNPF[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG4393[+]/CG4393^c04473

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CenG1A^c06703/CenG1A[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mtx2^d09179/CG8004[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by kug^c05977/kug[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Insep^e00355/CG32069[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by NetA[+]/NetA^d04075

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mtp[+]/Mtp^d07488

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Imp[+]/Imp^d08578

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by shn^c03635/shn[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by GCC185[+]/GCC185^e02741

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by eIF5B[+]/eIF5B^d02986

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Epac[+]/Epac^e00785

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by DCTN5-p25[+]/DCTN5-p25^f02738

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by f03408^f03408/f03408[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d06616[+]/d06616^d06616

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by GstS1^e00777/GstS1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ncoa6[+]/Ncoa6^e04200

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by f05963[+]/f05963^f05963

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Dg^e02580/Dg[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ets98B[+]/Ets98B^c04522

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG14434[+]/CG14434^c04582

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Klp98A[+]/Klp98A^c05668

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG8301^c06325/CG8301[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by corn^c02909/corn[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c04205[+]/c04205^c04205

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02712^d02712/d02712[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02380^d02380/d02380[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02874^d02874/d02874[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rgl^d03208/Rgl[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Moe^d04116/Moe[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02769[+]/d02769^d02769

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Fur1[+]/Fur1^d04883

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02833[+]/d02833^d02833

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG8036[+]/Tkt^d05884

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SNF4Aγ^d05297/SNF4Agamma[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mnr^e00651/CG32521[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d07098[+]/d07098^d07098

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsc70Cb[+]/Hsp110^d06126

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ptp61F[+]/Ptp61F^c05849

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Pld^HMS00529, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rala^HMS01365, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by lilli^JF02087, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SF2^HM05199, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SF2^HMS00358, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by d10800[+]/d10800^d10800

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp7^HMS01187, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp7^Δ1/Usp7[+]

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^RapGAP1-OK6 has some die during pupal stage phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^RapGAP1-OK6 has visible | adult stage phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^RapGAP1-OK6 has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has abnormal eye color | progressive phenotype, suppressible by Rpn11^UAS.cTa/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has abnormal eye color | progressive phenotype, suppressible by CG5445^UAS.cUa/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by Rpn11^UAS.cTa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Rala^S25N.UAS, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by mbl^KK107778, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-suppressible by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has abnormal eye color | progressive phenotype, non-suppressible by Scer\GAL4^GMR.PU/CG5445^ΔUBA.UAS

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has abnormal eye color | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by CG5445^ΔUBA.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Enhancer of

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is an enhancer of increased cell death phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is an enhancer of increased cell death phenotype of Scer\GAL4^GMR.PF, TER94^UAS.cRa

(Ritson et al., 2010)

Other

Statement

Reference

CG5445^NIG.5445R, Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has short lived phenotype

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Rpt6^KK108783, Scer\GAL4^GMR.PU has lethal phenotype

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF, TER94^R152H.UAS.R has lethal phenotype

(Ritson et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Strip[+]/Strip^e04482

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by sas[+]/sas^d07239

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by glo^f02674/glo[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by babo^HMS02033, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Smox^JF02320, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by babo^GD51, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Smox^HMS02203, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has eye | progressive phenotype, enhanceable by CG5445^NIG.5445R/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by TER94^R152H.UAS.R, Scer\GAL4^GMR.PF

(Ritson et al., 2010)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by TER94^R152H.UAS.R, Scer\GAL4^GMR.PF

(Ritson et al., 2010)

NOT Enhanced by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Suppressed by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02833[+]/d02833^d02833

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8036[+]/Tkt^d05884

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d07098[+]/d07098^d07098

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SNF4Aγ^d05297/SNF4Agamma[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Plp^d10223/Plp[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d08551^d08551/d08551[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsc70Cb[+]/Hsp110^d06126

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rbp9[+]/Rbp9^e02166

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mrva[+]/mrva^d09937

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Pld^HMS00529, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rala^HMS01365, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by lilli^JF02087, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SF2^HM05199, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SF2^HMS00358, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by d10800[+]/d10800^d10800

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ask1^HMS00464, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Setx[+]/Setx^f05408

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsc70Cb[+]/Hsp110^d03562

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dco[+]/dco^d06510

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Pka-R2^d02258/Pka-R2[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Atx-1^f01201/Atx-1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by orb[+]/orb^d06989

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by pum^d04225/pum[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by lilli[+]/lilli^c00800

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Fife^d01275/Fife[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d01345^d01345/d01345[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02712^d02712/d02712[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Nedd4[+]/Nedd4^c01016

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02380^d02380/d02380[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c01399^c01399/c01399[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d00147^d00147/d00147[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02769[+]/d02769^d02769

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corn^c02909/corn[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8301^c06325/CG8301[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Plp[+]/Plp^d11666

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c01295[+]/c01295^c01295

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by e00530^e00530/e00530[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG16890[+]/CG16890^e02098

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mnr^e00651/CG32521[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d10376[+]/d10376^d10376

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mus201[+]/mus201^e01238

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by rdo^e02234/rdo[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG11842[+]/CG11842^e02284

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG13334^e02535/CG13334[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Usp12-46^e02699/Usp12-46[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG5342[+]/CG5342^e01976

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hph^e00985/Hph[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by comm3[+]/comm3^e03409

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by e04545^e04545/e04545[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by nebu[+]/nebu^f03242

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by peo^e02684/CG46338[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NAT1^e04015/NAT1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG10011[+]/CG10011^f01587

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by RpS16[+]/RpS16^f06593

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mis12^f03756/Mis12[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by kug^c05977/kug[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c04797^c04797/c04797[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG4393[+]/CG4393^c04473

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ptpmeg[+]/Ptpmeg^c06293

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CenG1A^c06703/CenG1A[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Kpc1^c06744/Kpc1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Prp18^c07155/Prp18[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NetA[+]/NetA^d04075

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sra^c03600/sra[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mtp[+]/Mtp^d07488

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mtx2^d09179/CG8004[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Insep^e00355/CG32069[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp[+]/Imp^d08578

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DCTN5-p25[+]/DCTN5-p25^f02738

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by shn^c03635/shn[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by GCC185[+]/GCC185^e02741

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d06616[+]/d06616^d06616

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ptp61F[+]/Ptp61F^c05849

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Epac[+]/Epac^e00785

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ncoa6[+]/Ncoa6^e04200

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by GstS1^e00777/GstS1[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by eIF5B[+]/eIF5B^d02986

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by f03408^f03408/f03408[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by f05963[+]/f05963^f05963

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG14434[+]/CG14434^c04582

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ets98B[+]/Ets98B^c04522

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d00123[+]/d00123^d00123

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c07023^c07023/c07023[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c04205[+]/c04205^c04205

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corto[+]/corto^c03244

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Fur1[+]/Fur1^d04883

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02874^d02874/d02874[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rgl^d03208/Rgl[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Moe^d04116/Moe[+]

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Usp7^HMS01187, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Usp7^Δ1/Usp7[+]

(Zhang et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^RapGAP1-OK6 has wing phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has eye | progressive phenotype, suppressible by Rpn11^UAS.cTa/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has eye | progressive phenotype, suppressible by CG5445^UAS.cUa/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Rala^S25N.UAS, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by mbl^KK107778, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has eye | progressive phenotype, non-suppressible by Scer\GAL4^GMR.PU/CG5445^ΔUBA.UAS

(Uechi et al., 2018)

Hsap\TARDBP^{M337V.UAS.Tag:MYC} has eye | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS/Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Enhancer of

Statement

Reference

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lanson et al., 2011)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, TER94^UAS.cRa

(Ritson et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-progressive eye degeneration (loss of pigmentation, necrotic patches) characteristic for flies expressing Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU is mildly suppressed by co-expression of Rpn11^Scer\UAS.cTa (the number of flies with necrotic patches at day 15 post-eclosion is slightly decreased) and more strongly by co-expression of CG5445^Scer\UAS.cUa, whereas neither CG5445^{ΔUBA.Scer\UAS} nor CG5445^{ΔFW.Scer\UAS} can mitigate the phenotype; the eye degeneration is severely exacerbated by co-expression of CG5445^NIG.5445R.

The partial pupal lethality of animals expressing Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^RapGAP1-OK6 is strongly mitigated by co-expression of CG5445^Scer\UAS.cUa; the wing expansion and climbing defects observed in the Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC}-expressing flies that manage to eclose are also partially suppressed as flies that expand their wings normally are recovered and the percentage of adults that can climb is increased.

(Uechi et al., 2018)

Co-expression of Hsap\FUS^{Scer\UAS.T:Ivir\HA1} and Hsap\TARDBP^{M337V.Scer\UAS} in the developing eye under the control of Scer\GAL4^GMR.PF leads to severe eye degeneration.

(Lanson et al., 2011)

The eye degeneration phenotype found upon expression of TER94^{R152H.Scer\UAS.R} under the control of Scer\GAL4^GMR.PF is strongly enhanced by co-expression of Hsap\TARDBP^{M337V.Scer\UAS}.

(Ritson et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC}

Hsap\TARDBP^{M337V.Scer\UAS}

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

TDP-43^M337V

(Zhang et al., 2020)

hTDP-43^M337V

(Hwang et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (21)

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