FB2026_02 , released June 18, 2026
Allele: Dmel\DbctKO
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General Information
Symbol
Dmel\DbctKO
Species
D. melanogaster
Name
FlyBase ID
FBal0405779
Feature type
allele
Associated gene
Dmel\Dbct
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Hwang et al., 2024)
Progenitor genotype
Cytology
Description

1bp deletion in Dbct exon 2; results in a premature stop codon in exon 2.

(Hwang et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:15,086,840..15,086,840 [+]
Comment:

A 1bp deletion in Dbct in the codon for aaK37 leads to a frameshift and early translation termination.

(Hwang et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 10
      modeled by Hsap\TARDBPM337V.UAS.Tag:MYC
      (Hwang et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DBT KO
      (Hwang et al., 2024)
      DbctKO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)