FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mRNA-capHMS00631
Open Close
General Information
Symbol
Dmel\mRNA-capHMS00631
Species
D. melanogaster
Name
FlyBase ID
FBal0257315
Feature type
allele
Associated gene
Dmel\mRNA-cap
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00631}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00631}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00631
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis type 10
      modeled by Hsap\TARDBPM337V.UAS.Tag:MYC
      (Huber et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of mRNA-capHMS00631 under the control of Scer\GAL4Bx-MS1096 leads to adult wing deformation.

      (Chen et al., 2017)

      Females heterozygous for mRNA-capHMS00631 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to mRNA-capHMS00631 males results in: 59% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mRNA-capHMS00631 is rescued by mRNA-capUAS.Tag:HA/Scer\GAL4Bx-MS1096

      (Chen et al., 2017)
      Comments

      The deformed wing phenotype observed in adult flies expressing mRNA-capHMS00631 RNAi under the control of Scer\GAL4Bx-MS1096 can be rescued by co-expression of mRNA-capScer\UAS.T:Ivir\HA1.

      (Chen et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mRNA-capHMS00631
      Name Synonyms
      Secondary FlyBase IDs
        References (4)