FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cdmUAS.cGa
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General Information
Symbol
Dmel\cdmUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Giagtzoglou
FlyBase ID
FBal0240920
Feature type
allele
Associated gene
Dmel\cdm
Associated Insertion(s)
Carried in Construct
P{UAS-imp13.G}
Key Links
Transgenic product class
wild_type
(Giagtzoglou et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Giagtzoglou et al., 2009)
Mutagen
in vitro construct
(Giagtzoglou et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-imp13.G}
Cytology
Description

UASt regulatory sequences drive expression of the full length cdm coding sequence.

(Giagtzoglou et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cdm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 10
      modeled by Hsap\TARDBPM337V.UAS.Tag:MYC
      (Khalil et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Mhc.PW/cdmUAS.cGa partially rescues Df(3R)DG2/cdm164

      (Giagtzoglou et al., 2009)
      Fails to rescue

      Scer\GAL4elav-C155/cdmUAS.cGa fails to rescue Df(3R)DG2/cdm164

      (Giagtzoglou et al., 2009)
      Comments

      Expression of cdmScer\UAS.cGa under the control of Scer\GAL4Mhc.PW in cdm164/Df(3R)DG2 larvae rescues muscle size, the thickness of the subsynaptic reticulum and SSR density at the neuromuscular junction, but the lethality is not rescued.

      The increased amplitude of the evoked excitatory junctional potential at the larval neuromuscular junction that is seen at low concentrations (0.35mM and 0.5mM) extracellular Ca[2+] in cdm164/Df(3R)DG2 animals is not rescued by expression of cdmScer\UAS.cGa under the control of Scer\GAL4elav-C155, but is rescued by expression of cdmScer\UAS.cGa under the control of Scer\GAL4Mhc.PW.

      (Giagtzoglou et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cdmScer\UAS.cGa
      cdmUAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Giagtzoglou
      Secondary FlyBase IDs
        References (2)