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Citation
Giagtzoglou, N., Lin, Y.Q., Haueter, C., Bellen, H.J. (2009). Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.  J. Neurosci. 29(17): 5628--5639.
FlyBase ID
FBrf0207838
Publication Type
Research paper
Abstract

In an unbiased genetic screen designed to isolate mutations that affect synaptic transmission, we have isolated homozygous lethal mutations in Drosophila importin 13 (imp13). Imp13 is expressed in and around nuclei of both neurons and muscles. At the larval neuromuscular junction (NMJ), imp13 affects muscle growth and formation of the subsynaptic reticulum without influencing any presynaptic structural features. In the absence of imp13, the probability of release of neurotransmitter and quantal content is increased, yet the abundance of the postsynaptic receptors and the amplitude of miniature excitatory junctional potentials are not affected. Interestingly, imp13 is required in the muscles to control presynaptic release. Thus, imp13 is a novel factor that affects neurotransmitter release at the fly NMJ. Its role in the context of synaptic homeostasis is discussed.

PubMed ID
PubMed Central ID
PMC4011492 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurosci.
    Title
    Journal of Neuroscience
    Publication Year
    1981-
    ISBN/ISSN
    0270-6474 1529-2401
    Data From Reference
    Aberrations (4)
    Alleles (18)
    Genes (13)
    Polypeptides (1)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (5)
    Transgenic Constructs (7)