FlyBase Allele Report: Dmel\cdm[sd6]

General Information

Symbol

Dmel\cdm^sd6

Species

D. melanogaster

Name

FlyBase ID

FBal0151515

Feature type

allele

Associated gene

Dmel\cdm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Babcock et al., 2003)

Mutagen

ethyl methanesulfonate

(Babcock et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q351term.

(Giagtzoglou et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:18,182,136..18,182,136 [-]

Nucleotide change:

C18182136T

Amino acid change:

Q351term | cdm-PA; Q351term | cdm-PB

Reported amino acid change:

Q351term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Giagtzoglou et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | somatic clone

(Babcock et al., 2003)

abnormal phototaxis | somatic clone

(Babcock et al., 2003)

lethal (with cdm¹⁸)

(Babcock et al., 2003)

lethal (with cdm^sd4)

(Babcock et al., 2003)

lethal - all die before end of larval stage (with cdm¹⁶⁴)

(Giagtzoglou et al., 2009)

lethal - all die before end of larval stage (with cdm¹⁷⁷)

(Giagtzoglou et al., 2009)

lethal - all die before end of larval stage | recessive

(Babcock et al., 2003)

lethal - all die before end of second instar larval stage (with cdm^FY561)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with cdm^sd4)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with Df(3R)DG2)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with Df(3R)Exel6178)

(Giagtzoglou et al., 2009)

some die during larval stage | recessive

(Babcock et al., 2003)

some die during second instar larval stage (with cdm^FY561)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with cdm^sd4)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with Df(3R)DG2)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with Df(3R)Exel6178)

(Giagtzoglou et al., 2009)

some die during third instar larval stage (with cdm¹⁶⁴)

(Giagtzoglou et al., 2009)

some die during third instar larval stage (with cdm¹⁷⁷)

(Giagtzoglou et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mosaic animals in which the retina is homozygous for sd-5⁶ (generated using the "EGUF/hid" system) have normal external eye morphology but show defects in a phototaxis assay. The electroretinogram of mosaic animals in which the retina is homozygous for sd-5⁶ has defective on/off transients. Hemizygotes and homozygotes die as second instar larvae.

(Babcock et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions