FlyBase Allele Report: Dmel\cdm[FY561]

General Information

Symbol

Dmel\cdm^FY561

Species

D. melanogaster

Name

FlyBase ID

FBal0240914

Feature type

allele

Associated gene

Dmel\cdm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Giagtzoglou et al., 2009)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q811term.

(Giagtzoglou et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:18,180,466..18,180,466 [-]

Nucleotide change:

C18180466T

Amino acid change:

Q811term | cdm-PA; Q811term | cdm-PB

Reported amino acid change:

Q811term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Giagtzoglou et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | somatic clone

(Giagtzoglou et al., 2009)

lethal | recessive

(Giagtzoglou et al., 2009)

lethal - all die before end of larval stage (with cdm¹⁶⁴)

(Giagtzoglou et al., 2009)

lethal - all die before end of larval stage (with cdm¹⁷⁷)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with cdm^sd4)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with cdm^sd6)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with Df(3R)DG2)

(Giagtzoglou et al., 2009)

lethal - all die before end of second instar larval stage (with Df(3R)Exel6178)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with cdm^sd4)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with cdm^sd6)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with Df(3R)DG2)

(Giagtzoglou et al., 2009)

some die during second instar larval stage (with Df(3R)Exel6178)

(Giagtzoglou et al., 2009)

some die during third instar larval stage (with cdm¹⁶⁴)

(Giagtzoglou et al., 2009)

some die during third instar larval stage (with cdm¹⁷⁷)

(Giagtzoglou et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies with homozygous visual systems (made using the eyFLP method) and flies in which homozygous clones have been induced in the photoreceptors only (made using the ey3.5FLP system) show severe defects in electroretinogram (ERG) recordings. The ERGs lack both on and off transients, and the hyperpolarization curves are extremely reduced compared to wild type.

The terminals of homozygous R1-R6 photoreceptors form synaptic cartridges in the lamina and the number of synapses is normal, although the number of synaptic terminals per cartridge is more variable than controls. The ratio of mitochondrial area to photoreceptor terminal area is normal. The total number of capitate projections per cartridge is normal, but they are shallower than in wild type.

(Giagtzoglou et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions