FlyBase Allele Report: Dmel\Rpn11[UAS.cTa]

General Information

Symbol

Dmel\Rpn11^UAS.cTa

Species

D. melanogaster

Name

FlyBase ID

FBal0294982

Feature type

allele

Associated gene

Dmel\Rpn11

Associated Insertion(s)

Carried in Construct

P{UAS-Rpn11.T}

Also Known As

UAS-Rpn11

Key Links

Transgenic product class

wild_type

(Tonoki et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tonoki et al., 2009)

Mutagen

in vitro construct

(Tonoki et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Rpn11.T}

Cytology

Description

UASt regulatory sequences drive expression of Rpn11 coding sequences.

(Tonoki et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Rpn11

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Uechi et al., 2018)

ameliorates neurodegenerative disease

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Uechi et al., 2018)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tonoki et al., 2009)

modeled by Hsap\HTT^GMR.Q120

(Tonoki et al., 2009)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng and Chiang, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rpn11^UAS.cTa, Scer\GAL4^pnr-MD237 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^pnr-MD237, Txl^NIG.5495R

(Uechi et al., 2018)

Rpn11^UAS.cTa, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage | progressive phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Rpn11^UAS.cTa, Scer\GAL4^GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Rpn11^UAS.cTa/Scer\GAL4^GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Uechi et al., 2018)

Rpn11^UAS.cTa, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage | progressive phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Rpn11^UAS.cTa, Scer\GAL4^da.G32 is a suppressor | partially of short lived phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^da.G32

(Tonoki et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rpn11^UAS.cTa, Scer\GAL4^pnr-MD237 is a suppressor | partially of adult thorax phenotype of Scer\GAL4^pnr-MD237, Txl^NIG.5495R

(Uechi et al., 2018)

Rpn11^UAS.cTa/Scer\GAL4^GMR.PU is a suppressor of eye | progressive phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Uechi et al., 2018)

Rpn11^UAS.cTa, Scer\GAL4^GMR.PU is a suppressor of eye | progressive phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Rpn11^UAS.cTa/Scer\GAL4^GMR.PF is a suppressor of rhabdomere | progressive phenotype of Hsap\HTT^GMR.Q120

(Tonoki et al., 2009)

Rpn11^UAS.cTa/Scer\GAL4^GMR.PF is a suppressor of eye | progressive phenotype of Hsap\HTT^GMR.Q120

(Tonoki et al., 2009)

Rpn11^UAS.cTa, Scer\GAL4^GMR.PF is a suppressor of eye | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The abnormal dark pigmentation in the central thorax of adult flies expressing Txl^NIG.5495R under the control of Scer\GAL4^pnr-MD237 is strongly suppressed by co-expression of Rpn11^Scer\UAS.cTa (only a narrow dark stripe remains).

(Uechi et al., 2018)

Xenogenetic Interactions

Statement

Reference

The age-progressive eye degeneration and loss of pigmentation characteristic for flies expressing either Hsap\TARDBP^{M337V.Scer\UAS.T:Hsap\MYC} or Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is mildly suppressed by co-expression of Rpn11^Scer\UAS.cTa (the number of flies with necrotic patches at day 15 post-eclosion is slightly decreased).

(Uechi et al., 2018)

The progressive degeneration of the eye caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of Rpn11^Scer\UAS.cTa.

Co-expression of Rpn11^Scer\UAS.cTa partially suppresses the reduced lifespan caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^da.G32 during adulthood.

Co-expression of Rpn11^Scer\UAS.cTa (under the control of Scer\GAL4^GMR.PF) suppresses the age-related rhabdomeric loss seen in flies expressing Hsap\HTT^GMR.Q120.

(Tonoki et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rpn11^Scer\UAS.cTa

Rpn11^UAS.cTa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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