FlyBase Allele Report: Dmel\Txl[NIG.5495R]

General Information

Symbol

Dmel\Txl^NIG.5495R

Species

D. melanogaster

Name

FlyBase ID

FBal0274707

Feature type

allele

Associated gene

Dmel\Txl

Associated Insertion(s)

Carried in Construct

P{NIG.5495R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.5495R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-5495R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Phenotype Manifest In

adult thorax, with Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Detailed Description

Statement

Reference

Expression of Txl^NIG.5495R under the control of Scer\GAL4^pnr-MD237 leads to abnormal dark pigmentation in the central thorax of adult flies.

(Uechi et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by Rpn11^UAS.cTa, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by ple^KK101660/Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by Ddc^KK100293, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by CG5445⁶⁹

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by CG5445^GS1003

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, Txl^NIG.5495R, ple^KK101660 has visible | adult stage phenotype

(Uechi et al., 2018)

Ddc^KK100293, Scer\GAL4^pnr-MD237, Txl^NIG.5495R has visible | adult stage phenotype

(Uechi et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible | partially by CG5445^GS1003

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible by CG5445^GS1003, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible | partially by Rpn11^UAS.cTa, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible | partially by ple^KK101660/Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible | partially by Ddc^KK100293, Scer\GAL4^pnr-MD237

(Uechi et al., 2018)

Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype, suppressible | partially by CG5445⁶⁹

(Uechi et al., 2018)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, Txl^NIG.5495R, ple^KK101660 has adult thorax phenotype

(Uechi et al., 2018)

Ddc^KK100293, Scer\GAL4^pnr-MD237, Txl^NIG.5495R has adult thorax phenotype

(Uechi et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The abnormal dark pigmentation in the central thorax of adult flies expressing Txl^NIG.5495R under the control of Scer\GAL4^pnr-MD237 is strongly suppressed by co-expression of Rpn11^Scer\UAS.cTa (only a narrow dark stripe remains), ple^KK101660 or Ddc^KK100293 (with the latter two, two dark narrow stripes remain at the edges of the expression domain, whereas the rest of it is slightly depigmented and of lighter color than the lateral, wild-type, parts of the thorax). The abnormal pigmentation of Txl^NIG.5495R-expressing flies is also ameliorated by combination with either CG5445⁶⁹ or CG5445^GS1003 and fully suppressed by co-expression of CG5445^Scer\UAS.cUa.

(Uechi et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

5495R-1

P{NIG.5495R}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Txl^NIG.5495R

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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