FlyBase Allele Report: Dmel\Cth[1]

General Information

Symbol

Dmel\Cth¹

Species

D. melanogaster

Name

FlyBase ID

FBal0362608

Feature type

allele

Associated gene

Dmel\Cth

Associated Insertion(s)

TI{TI}Cth¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zatsepina et al., 2020)

Mutagen

CRISPR/Cas9

(Zatsepina et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}Cth¹

Cytology

Description

Deletion affecting Eip55E; begins in codon 116 and extends beyond the 3' end of the gene.

(Evgen'ev, 2020.11.5)

Part of the Eip55E gene has been deleted, and replaced with a mCherry-expressing reporter.

(Zatsepina et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:18,628,342..18,629,498 [+]

Comment:

Most of the Eip55E gene has been replaced with a mCherry-expressing reporter.

(Evgen'ev, 2020.11.5)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of homocystinuria

CEA

(Zatsepina et al., 2022)

CEC with Cbs⁵

(Zatsepina et al., 2022)

CEC with Cbs⁸

(Zatsepina et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Cbs⁵, Cth¹ has short lived phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has partially lethal phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has some die during P-stage phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has female semi-sterile phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has partially lethal phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has short lived phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has female semi-sterile phenotype

(Shilova et al., 2025)

Phenotype Manifest In

Other

Statement

Reference

Cbs⁵, Cth¹ has ovary phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has ovariole phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has ovary phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has Malpighian tubule phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has ovariole phenotype

(Shilova et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CSE(16)

(Shaposhnikov et al., 2022)

Cth¹

Eip55E¹

cse1

(Zatsepina et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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